Novel Approaches in Transdermal Drug Delivery System
Abstract
Transdermal patches are designed to deliver a therapeutically effective amount of drug across the skin membrane. In order to deliver therapeutic agents through the skin for systemic effects, the great physicochemical, morphological and biological properties of the skin are taken into consideration. Transdermal drug delivery system offers controlled release of drug substance into patient’s skin, it enables a mild blood level profile, resulting in reduced systemic side effects over the other dosage forms. Transdermal delivery is more convenient and painless technique for administration of drugs. It is likewise significant because of its interesting benefit such as less absorption, more uniform plasma levels, improved bioavailability, decrease side effect, efficacy and quality of the product. Transdermal dose structures may give clinicians a chance to offer more therapeutic alternatives to their patients to upgrade their consideration. The basic goal of TDDS is to administer medications at a predefined pace into systemic circulation through the skin with little inter- and interpatient variance. The basic goal of TDDS is to administer medications at a predefined pace into systemic circulation through the skin with little inter- and interpatient variance.
Keywords:
Transdermal drug delivery system (TDDS), Transport mechanism, Permeation mechanism, Iontophoresis, Microneedles
References
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https://doi.org/10.22377/ajp.v4i3.143
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http://dx.doi.org/10.5958/0974-360X.2015.00019.0
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https://doi.org/10.22377/ajp.v4i3.143
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https://doi.org/10.30574/gscbps.2021.15.3.0176
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https://doi.org/10.30574/wjarr.2023.19.2.1678
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https://dx.doi.org/10.7324/JAPS.2021.11s102
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https://doi.org/10.1111/bph.13059
23. P. Jahnavi , K. Krishnan , V. Rajashakar , G. S. Burle , K. T. K. Reddy , B. M. Yeruva , G. Dharmamoorthy and O. M. Bagade, "Organometallic Nanoparticulate Delivery: Synthesis, Properties, and Applications," Journal of Applied Organometallic Chemistry, 5 2 (2025): 123-148. doi: 10.48309/jaoc.2025.506438.1269
24. Rao, A Anka;,Rao, CH Babu, Devanna, N. 2017. DESIGN AND EVALUATION OF MUCOADHESIVE BUCCAL BILAYERED TABLETS OF METOPROLOL SUCCINATE. World journal of Pharmaceutical research.Vol.7.Issue.3.page-172-178.
25. 24. DASARI, VARUN; AWEN, BAHLUL Z; CHANDU, BABU RAO; MUKKANTI, KHAGGA; Formulation and in vitro evaluation of Lamivudine multiunit floating dosage forms using novel lipoidal polymers Int J Pharma Bio Sci 1 3 17-Jan 2010
26. Gindi S, Methra T, Chandu BR, Boyina R, Dasari V. Antiurolithiatic and invitro anti-oxidant activity of leaves of Ageratum conyzoides in rat. World J. Pharm. Pharm. Sci. 2013 Feb 8;2:636-49.
https://doi.org/10.22270/ajprd.v9i3.976
27. Alkilani AZ, Nasereddin J, Hamed R, Nimrawi S, Hussein G, Abo-Zour H, Donnelly RF. Beneath the skin: A review of current trends and future prospects of transdermal drug delivery systems. Pharmaceutics. 2022 May 28;14 (6): 1152. https://doi.org/10.3390/pharmaceutics14061152
https://doi.org/10.22377/ajp.v4i3.143
2. Barry BW. Modern methods of promoting drug absorption through the skin. Molecular Aspects of Medicine. 1991 Jan 1;12(3):195-241.
https://doi.org/10.1016/0098-2997(91)90002-4
3. Alkilani AZ, Nasereddin J, Hamed R, Nimrawi S, Hussein G, Abo-Zour H, Donnelly RF. Beneath the skin: A review of current trends and future prospects of transdermal drug delivery systems. Pharmaceutics. 2022 May 28;14(6):1152.
https://doi.org/10.3390/pharmaceutics14061152
4. Ramteke KH, Dhole SN, Patil SV. Transdermal drug delivery system: a review. Journal of Advanced Scientific Research. 2012 Feb 10;3(01):22-35. https://www.sciensage.info/index.php/JASR/article/view/72
5. Yadav N, Mittal A, Ali J, Sahoo J. Current updates in transdermal therapeutic systems and their role in neurological disorders. Current Protein and Peptide Science. 2021 Jun 1;22(6):458-69.
https://doi.org/10.2174/1389203721999201111195512
6. Malviya R, Tyagi A, Fuloria S, Subramaniyan V, Sathasivam K, Sundram S, Karupiah S, Chakravarthi S, Meenakshi DU, Gupta N, Sekar M. Fabrication and characterization of chitosan—tamarind seed polysaccharide composite film for transdermal delivery of protein/peptide. Polymers. 2021 May 10;13(9):1531.
https://doi.org/10.3390/polym13091531
7. Mahato RI, Narang AS. Pharmaceutical dosage forms and drug delivery: revised and expanded. CRC Press; 2017 Nov 22.
https://doi.org/10.1201/9781315156941
8. Adepu S, Ramakrishna S. Controlled drug delivery systems: current status and future directions. Molecules. 2021 Sep 29;26(19):5905.
https://doi.org/10.3390/molecules26195905
9. Soni D, Prakash K, Shakeel K, Kesharawani P. Current trends and recent development of transdermal drug delivery system TDDS. Asian Journal of Pharmaceutical Research and Development. 2023 Jun 30;11(3):181-9
https://doi.org/10.22270/ajprd.v11i3.1274
10. Leppert W, Malec–Milewska M, Zajaczkowska R, Wordliczek J. Transdermal and topical drug administration in the treatment of pain. Molecules. 2018 Mar 17;23(3):681
https://doi.org/10.3390/molecules23030681
11. Ali S, Shabbir M, Shahid N. The structure of skin and transdermal drug delivery system-a review. Res. J. Pharm. Technol. 2015 Feb 28;8(2):103-9.
http://dx.doi.org/10.5958/0974-360X.2015.00019.0
12. Hwisa NT, Gindi S, Rao CB, Katakam P, Rao Chandu B. Evaluation of Antiulcer Activity of Picrasma Quassioides Bennett Aqueous Extract in Rodents. Vedic Res. Int. Phytomedicine. 2013;1:27.
https://doi.org/10.1039/D0TB00021C
13. Sudam KR, Suresh BR. A Comprehensive Review on: Transdermal drug delivery systems. Int. J. Biomed. Adv. Res. 2016;7(4):147-59
http://dx.doi.org/10.7439/ijbar
14. Vaseem RS, D’cruz A, Shetty S, Vardhan A, Shenoy S, Marques SM, Kumar L, Verma R. Transdermal drug delivery systems: a focused review of the physical methods of permeation enhancement. Advanced Pharmaceutical Bulletin. 2023 Oct 14;14(1):67.
https://doi.org/10.34172/apb.2024.018
15. Mathur V, Satrawala Y, Rajput MS. Physical and chemical penetration enhancers in transdermal drug delivery system. Asian Journal of Pharmaceutics (AJP). 2010;4(3).
https://doi.org/10.22377/ajp.v4i3.143
16. Phatale V, Vaiphei KK, Jha S, Patil D, Agrawal M, Alexander A. Overcoming skin barriers through advanced transdermal drug delivery approaches. Journal of controlled release. 2022 Nov 1; 351:361-80
https://doi.org/10.1016/j.jconrel.2022.09.02
17. Mali AD. An updated review on transdermal drug delivery systems. skin. 2015;8(9):244-54.
http://dx.doi.org/10.7439/ijasr
18. Patil BR, Akarte AM, Chaudhari PM, Wagh KS, Patil PH. Development and characteristics of topical gel containing nimesulide: A review. GSC Biol. Pharm. Sci. 2021; 15:295-301.
https://doi.org/10.30574/gscbps.2021.15.3.0176
19. Muppa MR, Chetan G, Rakesh G. Formulation and evaluation of a novel controlled release mefenamic acid pluronic lecithin organogel. World Journal of Advanced Research and Reviews. 2023;19(2):1226-38.
https://doi.org/10.30574/wjarr.2023.19.2.1678
20. Nagpal M, Kaur M. Nanomaterials for skin antifungal therapy: An updated review. Journal of Applied Pharmaceutical Science. 2021 Feb 11;11(1):015-25
https://dx.doi.org/10.7324/JAPS.2021.11s102
21. Nama S, Chandu BR, Awen BZ, Khagga M. Development and validation of a new RP-HPLC method for the determination of aprepitant in solid dosage forms. Tropical Journal of Pharmaceutical Research. 2011;10(4):491-7.
https://doi.org/10.1186/2008-2231-21-6
22. Kiranmai M, Renuka P, Brahmaiah B, Chandu BR. Vitamin D as a promising anticancer agent.
https://doi.org/10.1111/bph.13059
23. P. Jahnavi , K. Krishnan , V. Rajashakar , G. S. Burle , K. T. K. Reddy , B. M. Yeruva , G. Dharmamoorthy and O. M. Bagade, "Organometallic Nanoparticulate Delivery: Synthesis, Properties, and Applications," Journal of Applied Organometallic Chemistry, 5 2 (2025): 123-148. doi: 10.48309/jaoc.2025.506438.1269
24. Rao, A Anka;,Rao, CH Babu, Devanna, N. 2017. DESIGN AND EVALUATION OF MUCOADHESIVE BUCCAL BILAYERED TABLETS OF METOPROLOL SUCCINATE. World journal of Pharmaceutical research.Vol.7.Issue.3.page-172-178.
25. 24. DASARI, VARUN; AWEN, BAHLUL Z; CHANDU, BABU RAO; MUKKANTI, KHAGGA; Formulation and in vitro evaluation of Lamivudine multiunit floating dosage forms using novel lipoidal polymers Int J Pharma Bio Sci 1 3 17-Jan 2010
26. Gindi S, Methra T, Chandu BR, Boyina R, Dasari V. Antiurolithiatic and invitro anti-oxidant activity of leaves of Ageratum conyzoides in rat. World J. Pharm. Pharm. Sci. 2013 Feb 8;2:636-49.
https://doi.org/10.22270/ajprd.v9i3.976
27. Alkilani AZ, Nasereddin J, Hamed R, Nimrawi S, Hussein G, Abo-Zour H, Donnelly RF. Beneath the skin: A review of current trends and future prospects of transdermal drug delivery systems. Pharmaceutics. 2022 May 28;14 (6): 1152. https://doi.org/10.3390/pharmaceutics14061152
Published
30/04/2025
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Degapati, R. T. (2025). Novel Approaches in Transdermal Drug Delivery System. The Journal of Multidisciplinary Research, 5(1), 20-25. https://doi.org/10.37022/tjmdr.v5i1.692
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