A COMPREHENSIVE REVIEW ON ORODISPERSIBLE TABLTES

Sharon N

N. Sharon Priyadarshini Institute of Pharmaceutical Education and Research, 5th Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.

Abstract

In the pharmaceutical industry oral route is considered as the safest and convenient route. Oro-dispersible tablets (ODTs) are solid dosage forms containing drugs that disintegrate in the oral cavity within less than 1 minute leaving an easy to swallow residue. These dosage form contains super disintegrants which imparts quick disintegration with presence of saliva and can be swallowed easily. ODTs are the very good choice for the paediatric and geriatric patients. To improve the bioavailability of many drugs, Oro dispersible drug delivery systems are used extensively. In recent past, several manufacturing technologies such as sublimation technique, spray drying technique etc… are employed to overcome the limitations of conventional tablet dosage forms. The mouth dissolving tablets must undergo a variety of evaluations after they are created in order to ensure their long-term stability and improved therapeutic effectiveness.

Keywords: Oro-dispersible tablets, superdisintegrants, bioavailability enhancement, pediatric and geriatric patients, sublimation technique, spray drying technique

Downloads

Download data is not yet available.

References

1. Nama S, Chandu BR, Awen BZ, Khagga M. Devel-opment and validation of a new RP-HPLC method for the determination of aprepitant in solid dosage forms. Trop J Pharm Res. 2011 Aug;10(4). https://www.ajol.info/index.php/tjpr/article/view/69565
2. Gindi S, Methra T, Chandu BR, Boyina R, Dasari V. Antiurolithiatic and in vitro antioxidant activity of leaves of Ageratum conyzoides in rat. World J Pharm Pharm Sci. 2013;2:636–649. https://www.researchgate.net/profile/Revathi-Boyina/publication/251566463
3. Vijayalakshmi P, Girish C, Mentham R, Rao CB, Nama S. A review on Alzheimer’s disease. Int J Pharma Biosci. 2014 Apr;4(2):19–27.
4. Gandhi L, Akhtar S. Comparative study on effect of natural and synthetic superdisintegrants in oro-dispersible tablets. J Drug Deliv Ther. 2019 Mar;9(2):507–513. https://doi.org/10.22270/jddt.v9i2.2404
5. Panda SA, Hemalatha NO, Shankar PU, Baratam SR. Formulation and evaluation of orodispersible tablets of diclofenac sodium. Int J App Pharm. 2019;11(6):190–197. http://dx.doi.org/10.22159/ijap.2019v11i6.33480
6. Reshma KJ, Senthila S. Superdisintegrants and their role in orodispersible tablets. Int J Res Rev. 2020;7:462–471.
7. Valleri M, Mura P, Maestrelli F, Cirri M, Ballerini R. Fast dissolving tablets using solid dispersion tech-nique. Drug Dev Ind Pharm. 2004 Jan;30(5):525–534. https://doi.org/10.1081/DDC-120037484
8. Seager H. Drug-delivery products and the Zydis fast-dissolving dosage form. J Pharm Pharmacol. 1998 Apr;50(4):375–382. https://doi.org/10.1111/j.2042-7158.1998.tb06876.x
9. Hirani JJ, Rathod DA, Vadalia KR. Orally disinte-grating tablets: a review. Tropical Journal of Pharma-ceutical Research. (Year not provided). http://www.tjpr.org
10. Chandrasekhar R, Hassan Z, AlHusban F, Smith AM, Mohammed AR. Role of excipients in lyophi-lised fast-disintegrating tablets. Eur J Pharm Bio-pharm. 2009 May;72(1):119–129. https://doi.org/10.1016/j.ejpb.2008.11.011
11. Mishra DN, Bindal M, Singh SK, Kumar SG. Spray dried excipient base for orally disintegrating tab-lets. Chem Pharm Bull. 2006;54(1):99–102. https://doi.org/10.1248/cpb.54.99
12. Gupta A, Mishra AK, Gupta V, Bansal P, Singh R, Singh AK. Fast dissolving tablet formulation tech-nology: an overview. Int J Pharm Biol Arch. 2010;1(1):1–10.
13. Sunada H, Bi Y. Preparation and evaluation of rap-idly disintegrating tablets. Powder Technol. 2002;122(2–3):188–198. https://doi.org/10.1016/S0032-5910(01)00415-6
14. Morita Y, Tsushima Y, Yasui M, et al. Evaluation of disintegration time of rapidly disintegrating tablets using CCD camera. Chem Pharm Bull. 2002;50(9):1181–1186. https://doi.org/10.1248/cpb.50.1181
15. Yalkowsky SH, Banerjee S. Aqueous solubility: methods of estimation for organic compounds. 1992. https://lccn.loc.gov/91041408
16. Cirri M, Rangoni C, Maestrelli F, Corti G, Mura P. Fast-dissolving tablets of flurbiprofen-cyclodextrin complexes. Drug Dev Ind Pharm. 2005;31(7):697–707. https://doi.org/10.1080/03639040500253694
17. Mehta K, Garala K, Basu B, Bhalodia R, Joshi B, Charyulu RN. Rapid disintegrating tablets: emerg-ing oral drug delivery technology. (Source not fully provided).
18. Yalkowsky SH, Banerjee S. Aqueous solubility: methods of estimation. 1992. https://lccn.loc.gov/91041408
19. Sandeep Yadav SY, Sharma PK, Goyal NK. Com-parative study of mucilage from Cassia fistula and gum Karaya. (Journal details incomplete).
20. Kumar N, Pahuja S. Dispersible tablets: an over-view. J Med Pharm Allied Sci. 2019;8(3):2183–2199.