‘‘Ginkgo biloba” a comprehensive review of its therapeutic potentials

  • M. Prashanthi Evangelin Professor and Vice Principal, Department of Pharmaceutical Chemistry, SIMS College of Pharmacy, Guntur, AP. India
  • Kakunuri Ravi B.Pharmacy, Department of Pharmacy, SIMS College of Pharmacy, Guntur, AP. India
  • Motupalli Chaitanya Ganesh B.Pharmacy, Department of Pharmacy, SIMS College of Pharmacy, Guntur, AP. India
  • M. Tibamning B.Pharmacy, Department of Pharmacy, SIMS College of Pharmacy, Guntur, AP. India
  • Bathula Anand Paul B.Pharmacy, Department of Pharmacy, SIMS College of Pharmacy, Guntur, AP. India
  • Pathan Ruksana B.Pharmacy, Department of Pharmacy, SIMS College of Pharmacy, Guntur, AP. India

Abstract

The "living fossil," Ginkgo Biloba has long been used in medicine. Both leaves and nuts are frequently given to treat a variety of illnesses, including as alcoholism, dementia, pulmonary disease, Alzheimer disease heart and bladder malfunction, dementia and lung infections. containing extracts and separated substances such organic acids, bioflavonoids, and flavonoids. Anxiety, stress, and depression are psychological disorders that are so prevalent that they will become the second most significant risk factor for morbidity and sociodemographic burden. to offer a range of health advantages to living things and is rich in bioactive substances, making it a chemically diverse plant with a number of pharmacological and therapeutic qualities, such as anti-lipidemic and anti-dementia effects. the most common herbal medicines in Europe is ginkgo biloba leaf extract, which is used to treat vascular dementia, early-stage Alzheimer's disease, peripheral isolation, and the condition of vascular origin. Additionally, it is among the top ten herbal remedies in several states. The quality life for healthy people can also be improved by the herbal extracts. In addition to producing against endothelial damage, G. biloba is useful against inner ear disorders. In addition, scientific research has shown that it contains antiviral, antibacterial, and antioxidant properties. Many effects, including anti-diabetic, anti-cancer, and cardioprotective Ginkgo properties have been scientifically verified, making it a significant nutraceutical. The scientific community is becoming more interested in this plant.One of the the main causes of dementia in older adults globally is Alzheimer's disease, a neurodegenerative condition. People with Alzheimer's disease experience disorientation, social marginalisation, and isolation as a result of the loss of neuronal structure and function in many brain regions. The utilisation of natural bioactive chemicals to treat neurodegenerative illnesses, such as Alzheimer's disease, has received increasing interest in recent years. The most widely used standardised extract of G. biloba.

Keywords: Ginkgo Biloba, Ethnobotany, Biological Activity

Downloads

Download data is not yet available.

References

1. T. Belwal, L. Giri, A. Bahukhandi, M. Tariq, P. Kewlani, I.D. Bhatt, R.S. Rawal Chapter 3.19 – Ginkgo biloba, in: S.M. Nabavi, A.S. Silva (Eds.), Nonvitamin and Nonmineral Nutritional Supplements, Academic Press, 2019, pp. 241–250.
2. E.T. Noor, R. Das, M.S. Lami, A.J. Chakraborty, S. Mitra, T.E. Talib, K. Idroes, A.A. Mohamed, M.J. Hossain, K. Dhama, G. Mostafa-Hedeab, T.B. EmranGinkgo biloba: a treasure of functional phytochemicals with multimedicinalapplications,Evid. Based Complement. Alternat. Med. 2022 (2022), 8288818.
3. Y. Liu, H. Xin, Y. Zhang, F. Che, N. Shen, Y. Cui
Leaves, seeds and exocarp of Ginkgo biloba L. (Gink-goaceae): a comprehensive review of traditional uses, phytochemistry, pharmacology, resource utili-zation and toxicity,J. Ethnopharmacol. 298 (2022), 115645.
4. J. Hort, T. Duning, R. Hoerr Ginkgo biloba extract EGb 761 in the treatment of patients with mild neu-rocognitive impairment: a systematic review,
Neuropsychiatr. Dis. Treat. 19 (2023) 647–660.
5. L. Xie, Q. Zhu, J. Lu Can we use Ginkgo biloba extract to treat Alzheimer’s disease? Lessons from preclini-cal and clinical studies,Cells 11 (3) (2022).
6. Ž. Kulic, M.D. Lehner, G.P.H. Dietz *Ginkgo biloba leaf extract EGb 761 Liu, Y., Xin, H., Zhang, Y., Che, F., Shen, N., & Cui, Y. (2022).Leaves, seeds and exocarp of Ginkgo biloba L. (Ginkgoaceae): a comprehensive review of traditional uses, phytochemistry, pharmacology, resource utilization and toxicity.Journal of Ethnopharmacology, 115645.
7. Barnes, J., Anderson, L. A., & Phillipson, J. D. (2007). Herbal medicines. Pharmaceutical Press.
8. Zhou, Z. Y., Yang, X. J., & Wu, X. W. (2020). Pa-leobotanica Sinica (Ginkgophytes). Science Press (in Chinese).
9. Demirezer, L., Ersöz, T., Saraçoğlu, İ., & Şener, B. (2012). TedavideKullanılan Bitkiler FFD Monogra-fları.
10. Trommer, B. L., Shah, C., Yun, S. H., Gamkrelidze, G., Pasternak, E. S., Stine, W. B., et al. (2005). ApoE Iso-form-specific Effects on LTP: Blockade by Oligomeric Amyloid-Beta1–42. Neurobiology of Disease, 18(1), 75–82.
11. A. M. (2012). Attenuating effect of Ginkgo biloba leaves extract on liver fibrosis induced by thio-acetamide in mice. J Biomed Biotechnol, 2012, 761450. https://doi.org/10.1155/2012/761450
12. H. M., Tan, Y. L., Shi, J., Wang, Z., Lv, M. H., Soares, J. C., Zhou, D., Yang, F., & Zhang, X. Y. (2016). Ginkgo bilobaleaf extract and alpha-tocopherol attenuate haloperidol-induced orofacial dyskinesia in rats: Possible implication of antiapoptotic mechanisms by preventing Bcl-2 decrease and Bax elevation. Phy-tomedicine, 23(13), 1653-1660.
13. Bai, Y., Zhao, F., Li, Y., Wang, L., Fang, X. J., & Wang, C. Y. (2015). Ginkgo biloba extract induce cell apoptosis and G0/G1 cycle arrest in gastric cancer cells. Int J Clin Exp Med, 8(11), 20977-20982.
14. Balkaya, A., &Yanmaz, R. (2001). Bitki genetikkay-naklarınınmuhafazaimkanlarıvetohum gen bankalarınınçalışmasistemleri. Ekoloji Çevre Dergisi, 10(39), 25-30.
15. Barnes, J., Anderson, L. A., & Phillipson, J. D. (2007). Herbal medicines. Pharmaceutical press.
16. S. M., Ruge, H., Schindler, C., Burkart, M., Miller, R., Kirschbaum, C., & Goschke, T. (2016). Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment–a randomized double‐blind placebo‐controlled trial. Human Psychopharmacol-ogy: Clinical and Experimental, 31(3), 227-242.
17. Bikram, S., Pushpinder, K., Gopichand, S. R., & Ahuja, P. (2008). Biology and chemistry of Ginkgo biloba. Fitoterapia, (6), 401-418.
18. M., Busse, W. R., Medizinprodukte, B. f. A. u., & Council, A. B. (1998). The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. American Botanical Council.
19. M., Goldberg, A., & Brinckmann, J. (2000). Herbal medicine. Expanded commission E monographs. In-tegrative Medicine Communications. Bressler, R. (2005). Herb-drug interactions. Geriatrics, 60(4).
20. C., Su, Y., Han, D., Gao, Y., Zhang, M., Chen, H., & Xu, A. (2017, Feb 23). Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways. J Ethnopharmacol, 198, 379-388.
21. Çekkayan, S., Özlüoğlu, L., Yoloğlu, S., Söylemezoğlu, S., &Erpek, G. (1996). Tinnituslu Hastalarda Beta-histin ve Ginkgo Biloba EkstresininEtkinliğininKarşi-laştirilması. Çelik, O., & MB, Ş. (2002). Otoloji venöro-otolojideöykü, muayenevedeğerlendirme. Kulak Burun BoğazHastalıkları ve Baş BoyunCerrahisi. Turgut Yayıncılık İstanbul, 1, 29.
22. J. C.-J., Hung, H.-C., Chen, S.-H., & Fang, C.-L. (2004). Effects of Ginkgo biloba extract on cytoprotective factors rats with duodenal ulcer. World Journal of Gastroenterology, 10(4), 560.
23. J., Wang, BBBX., Zhu, J., Shang, Y., Guo, X., & Sun, J. (2004). Effects of Ginkgo biloba extract on number and activity of endothelial progenitor cells from pe-ripheral blood. Journal of cardiovascular pharmacol-ogy, 43(3), 347-352. Cheng, D., Liang, B., & Li, Y. (2013). Antihyperglycemic effect of Ginkgo biloba extract in streptozotocin-induced diabetes in rats. BioMed research international, 2013.
24. H.-K., Kim, S., Lee, E. J., & Kee, C. (2019). Neuropro-tective effect of Ginkgo biloba extract against hypoxic retinal ganglion cell degeneration in vitro and in vivo. Journal of medicinal food, 22(8), 771-778.
25. K. S., Lee, I. M., Sim, S., Lee, E. J., Gonzales, E. L., Ryu, J. H., Cheong, J. H., Shin, C. Y., Kwon, K. J., & Han, S. H. (2016, Jan). Ginkgo biloba Extract (EGb 761®) Inhibits Glutamate-induced Up-regulation of Tissue Plasminogen Activator Through Inhibition of c-Fos Translocation in Rat Primary Cortical Neurons. Phytother Res, 30(1), 58-
26. X., Ci, X., He, J., Wei, M., Yang, X., Cao, Q., Li, H., Guan, S., Deng, Y., & Pang, D. (2011). A novel anti-inflammatory role for ginkgolide B in asthma via in-hibition of the ERK/MAPK signaling pathway. Mole-cules, 16(9), 7634-7648.
27. A. J., & Bartlik, B. (1998). Ginkgo biloba for antide-pressant-induced sexual dysfunction. Journal
28. R. Montanini, G. Gaspari, Use of an extract of ginkgo biloba (Tebonin) in the therapy of cerebral vascular diseases, Minerva Cardioangiol. 17 (12) (1969)
1096–1102.
29. G.R. Locatelli, E. Sorbini, Effetti del Tebonin, Effects of Tebonin (extract from leaves of ginkgo biloba L in the treatment of senile peripheral arteriopathies,
Minerva Cardioangiol. 17 (12) (1969) 1103–1108.
30. X.G. Liu, X. Lu, W. Gao, P. Li, H. Yang, Structure, syn-thesis, biosynthesis, and activity of the characteristic compounds from Ginkgo biloba L, Nat. Prod. Rep. 39 (3) (2022) 474–511. https://doi:10.1039/d1np00026h.
Published
30/09/2025
Statistics
132 Views | 144 Downloads
Citatons
How to Cite
M, P. E., R. Kakunuri, C. G. Motupalli, T. M, A. P. Bathula, and R. Pathan. “‘‘Ginkgo biloba” a Comprehensive Review of Its Therapeutic Potentials”. International Journal of Pharmacognosy and Chemistry, Vol. 6, no. 3, Sept. 2025, pp. 25-32, doi:10.46796/ijpc.v6i3.741.
Section
Review Article