Commonly used natural products as wound healers: A Comprehensive Review of ayurvedic herbal plants and Non-Clinical Applications
Abstract
The process of wound healing involves a synchronized series of cellular and biochemical stages that work together to support the recovery of the damaged tissue. The complexity of tissue healing makes wound care difficult. The three stages of healing are remodelling, proliferative, and inflammatory. Antibiotics, antiseptics, and extracts are among the treatments; nevertheless, synthetic medications have drawbacks. Plant-based compositions for the efficient healing of wounds are gaining popularity. Studies showing numerous discovered mechanisms for better healing have reinforced the growing recognition of medicinal plants' ability to heal wounds with fewer side effects, especially in diabetic, infected, or open wounds. Many medicinal plants, including Aloe Vera , Centella asiatica, Neem, Tulsi, Achiote (BixaOrellana)have shown promise in healing wounds. The effectiveness of medicinal plants in excision and incision wound healing is examined in this review, which focuses on in-vivo models.
Downloads
References
2. haneef aa, abraham as, anjana s, mathew a. formulation, evaluation and antimicrobial activity of evolvulusalsinoides cream. the american journal of interdisciplinary innovations and research. 2022 may 24;4(05):5-22.
3. Sirsat SV, Rathi NM, Hiwale AS, Shelke PB. A review on preparation and evaluation of herbal cold cream. World Journal of Pharmaceutical Research. 2022 Mar 8;11(5):690-7.
4. Valverde TM, Soares BN, Nascimento AM, Andrade ÂL, Sousa LR, Vieira PM, Santos VR, Seibert JB, Almeida TC, Rodrigues CF, Oliveira SR. Anti-Inflammatory, Antimicrobial, Antioxidant and Photoprotective Investigation of Red Propolis Extract as Sunscreen Formulation in Polawax Cream. International Journal of Molecular Sciences. 2023 Mar 7;24(6):5112.
5. Kalogeropoulos, N.; Konteles, S.J.; Troullidou, E.; Mourtzinos, I.; Karathanos, V.T. Chemical composition, antioxidant activity and antimicrobial properties of propolis extracts from Greece and Cyprus. Food Chem. 2009, 116, 452–461.
6. Kavya ms, dc k, eshwari gm, navyashreeps, jagadeesh cs. a short review on: pharmaceutical cream for skin care.2023, volume 12, issue 19, 153-162
7. Sharma A, Banyal M, Gupta J, Joshi S. formulation and evaluation of herbal cold cream, vol-9 issue-3 2023 ijariie-issn(o)-2395-4396.
8. Patil AK, Haque MA, Khan N. review of herbal vanishing cream,2023, volume 12, issue 22, 690-699, issn 2277–7105
9. Pawar MS, Bhagat MV, Jadhav MV, Rode MA. formulation and evaluation of moisturizing cream, volume:05, issue:05, may-2023, e-issn: 2582-5208.
10. Krishnan N, Afsal VI, Jamal F, Rasheed R, PP SS. formulation and evalution of herbal vanishing cream, 2022, volume 11, issue 10, 834-865.
11. Chhabra S, Chhabra N, Kaur A, Gupta N. Wound healing concepts in clinical practice of OMFS. Journal of maxillofacial and oral surgery. 2017 Dec; 16:403-23.
12. Das T, Debnath JI, Nath B, Dash SU. Formulation and evaluation of an herbal cream for wound healing activity. Int J Pharm Pharm Sci. 2014;6(2):693-7.
13. Rastegari A, Manayi A, Akbarzadeh T, Hojjatifard R, Samadi N, Khanavi M, Niknam S, Saeedi M. Cedrus deodara: In Vivo Investigation of Burn Wound Healing Properties. Evidence-Based Complementary and Alternative Medicine. 2023 Apr 7;2023.
14. Ratz-Lyko A, Arct J, Pytkowska K. Moisturizing and antiinflammatory properties of cosmetic formulations containing Centella asiatica extract. Indian journal of pharmaceutical sciences. 2016 Jan;78(1):27.
15. El Mihyaoui A, Esteves da Silva JC, Charfi S, Candela Castillo ME, Lamarti A, Arnao MB. Chamomile (Matricaria chamomilla L.): a review of ethnomedicinal use, phytochemistry and pharmacological uses. Life. 2022 Mar 25;12(4):479.
16. Luu ND, Do TD, Nguyen TT, Nguyen TT, Nguyen TP, Tran NQ. Topical cream based on nanoformulation of Chromolaena odorata extract for accelerating burn wound healing. Journal of Drug Delivery Science and Technology. 2023 Apr 1;82:104360.
17. Wadher KJ, Lakhotia CL, Umekar MJ. Formulation and evaluation of cream of Azadirachta indica leaves extracts on skin renewal rate. International Journal of ChemTech Research. 2009 Jan;1(1):88-95.
18. Al-Busaid MM, Akhtar MS, Alam T, Shehata WA. Development and evaluation of herbal cream containing Curcumin from Curcuma longa. Pharm Pharmacol Int J. 2020;8(5):285-9.
19. Bardaa S, Makni K, Boudaouara O, Bardaa T, Ktari N, Hachicha S, Ben Salah R, Kallel R, Sahnoun Z, Boufi S. Development and evaluation of the wound healing effect of a novel topical cream formula based on Ginkgo biloba extract on wounds in diabetic rats. BioMed Research International. 2021 Oct 13;2021.
20. Virych P, Nadtoka O, Doroschuk V, Lelyushok S, Chumachenko V, Bezugla T, Kutsevol N. Cefuroxime-loaded hydrogels for prevention and treatment of bacterial contamination of open wounds. International Journal of Polymer Science. 2021 Nov 8;2021:1-7.
21. Pal A, Soni M, Patidar K. Formulation and evaluation of polyherbal cream. International Journal Pharmaceutical and Biological Archives. 2014;5:67-71.
22. Unnithan AR, Barakat NA, Pichiah PT, Gnanasekaran G, Nirmala R, Cha YS, Jung CH, El-Newehy M, Kim HY. Wound-dressing materials with antibacterial activity from electrospun polyurethane–dextran nanofiber mats containing ciprofloxacin HCl. Carbohydrate polymers. 2012 Nov 6;90(4):1786-93.
23. Bowen AC, Carapetis JR, Currie BJ, Fowler Jr V, Chambers HF, Tong SY. Sulfamethoxazole-trimethoprim (cotrimoxazole) for skin and soft tissue infections including impetigo, cellulitis, and abscess. InOpen forum infectious diseases 2017 (Vol. 4, No. 4, p. ofx232). US: Oxford University Press.
24. Sirsat SV, Rathi NM, Hiwale AS, Shelke PB. A review on preparation and evaluation of herbal cold cream. World Journal of Pharmaceutical Research. 2022 Mar 8;11(5):690-7.
25. Chatur VM, Ansari NM, Joshi SK, Walode SG, Formulation and Evaluation of Polyherbal Cream, Journal of Drug Delivery and Therapeutics. 2022; 12(4):112-115.
26. Ranganathan K, Jeevanandham S, Rinshida PA. development and evaluation of herbal cream for rheumatism. Journal of Population Therapeutics and Clinical Pharmacology. 2023 Dec 28;30(19):1452-63.
27. Deepa V, Kulkarni GS, Paarakh PM. Formulation and evaluation of topical anti-microbial herbal cream, 2022, 12(02), 156–167.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.

.