Warburgia Ugandensis: A Review of Compounds and Bioactivity
Abstract
Warburgia species (Canellaceae) are traditionally used to treat a wide range of illnesses including stomach ache, diarrhea, abdominal pains, toothache, oral thrush, venereal diseases, cold and cough, fever, muscle pains, weak joints, skin diseases, malaria, parasitic infections and snake bite. Therapeutic properties of medicinal plants have been linked to the secondary metabolites which are biosynthesized by the plants. The aim of this study was to review the bioactivities and chemical composition of Warburgia ugandensis. The findings from this study show that extracts from the plant have antifungal, antibacterial, antiulcer, insect antifeedant, molluscicidal, antimycobacterial, antileishmanial and anti-plasmoidal effects. The most investigated part of W. ugandensis is the stem bark (22 articles) followed by leaves (15), root bark (6), seeds (2) and fruits (2). All parts the plant have important bioactivities. Sixty nine compounds have been reported from the plant including sesquiterpenes (43), flavonoids (15), lignanamides, and macrocyclic glycosides (10) and fatty acid (1) some of which have demonstrated different bioactivities. The drimane sesquiterpenes are the main class of sesquiterpenes in the plant. The Further investigation of the not well studied parts of the plant such as the flowers and fruits is recommended to determine their chemical composition and efficacy in disease management.
Keywords:
Warburgia ugandensis, compounds, Biological activities
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References
1. World Health Organization. WHO Traditional Medicine Strategy: 2014-2023. World Health Organization; 2013. Accessed February 27, 2023.
2. Kokwaro JO. Medicinal Plants of East Africa. 3rd ed. University of Nairobi Press; 2009.
3. Jeruto P, Arama P, Anyango B, Nyunja R, Taracha C, Opiyo S. Morphometric Study of Senna didymobotrya (Fresen.) H. S. Irwin and Barneby in Kenya. J Nat Sci Res. 2017;7:54-69.
4. Opiyo S. Stored Grains Protection Activity of Ocimum Suave Extracts and Compounds on Larger Grain Borer. IOSR Journal of Biotechnology and Biochemistry. 2022;8(4):5-10. doi:10.9790/264X-08040510
5. Ndirangu EG, Opiyo SA, Ng’ang’a MW. Chemical composition and repellency of Nigella sativa L. seed essential oil against Anopheles gambiae sensu stricto. Trends Phytochem Res. 2020;4(2):77-84.
6. Njoroge PW, Opiyo SA. Antimicrobial Activity of Root Bark Extracts of Rhus natalensisa and Rhus ruspolii. Basic Sciences of Medicine. 2019;8(2):23-28. doi:doi:10.5923/j.medicine.20190802.01
7. Ochieng C, Ishola I, Opiyo S, Manguro L, Owuor P, Wong KC. Phytoecdysteroids from the Stem Bark of Vitex doniana and Their Anti-Inflammatory Effects. Planta Med. 2013;79(1):52-59. doi:10.1055/s-0032-1327880
8. Opiyo SA, Manguro LOA, Owuor PO, Ateka EM. Triterpenes from Elaeodendron schweinfurthianum and Their Antimicrobial Activities against Crop Pathogens. American Journal of Chemistry. 2017;7(3):97-104. doi:doi:10.5923/j.chemistry.20170703.03
9. Opiyo SA, Manguro LO, Ogur J, Wagai S. Bioactive Constituents of Conyza floribunda. Research Journal of Pharmacology. 2010;4(3):55-59. doi:10.3923/rjpharm.2010.55.59
10. Opiyo SA. Evaluation of Warburgia ugandensis Extracts and Compounds for Crop Protection against Prostephanus truncates. Advances in Analytical Chemistry. 2020;10(2):15-19. doi:doi:10.5923/j.aac.20201002.01
11. Opiyo SA. Triterpenes and Sterols from Ocimum suave. IOSR J Appl Chem. 2022;15(7):1-6. doi:doi:10.9790/5736-1507010106
12. Ochung AA, Owuor PO, Manguro LAO, et al. Analgesics from Lonchocarpus eriocalyx Harms. Trends Phytochem Res. 2018;2(4):253-260.
13. Ndirangu EG, Opiyo SA, Ng’ang’a MW. Repellent Properties of Compounds and Blends from Nigella sativa Seeds Against Anopheles gambiae. Basic Sciences of Medicine. 2020;9(1):1-7. doi:doi:10.5923/j.medicine.20200901.01
14. Opiyo SA, Ogur JA, Manguro LOA, Tietze LF, Schuster H. A New Sterol Diglycoside from Conyza floribunda. S Afr J Chem. 2009;62:163-167.
15. Njoroge PW, Opiyo SA. Some Antibacterial and Antifungal Compounds from Root Bark of Rhus natalensis. American Journal of Chemistry. 2019;9(5):150-158. doi:doi:10.5923/j.chemistry.20190905.03
16. Makenzi AM, Manguro LOA, Owuor PO, Opiyo SA. Chemical constituents of Ocimum kilimandscharicum Guerke acclimatized in Kakamega Forest, Kenya. Bull Chem Soc Eth. 2019;33(3):527. doi:10.4314/bcse.v33i3.13
17. Opiyo SA. Chemical Composition of Essential Oils from Ocimum Kilimandscharicum: A Review. IOSR Journal of Applied Chemistry. 2022;15(11):5-11.
18. Opiyo SA, Njoroge PW, Ndirangu EG. A Review Pesticidal Activity of Essential Oils against Sitophilus oryzae, Sitophilus granaries and Sitophilus Zeamais. IOSR J Appl Chem. 2022;15(4):39-51. doi:doi:10.9790/5736-1504013951
19. Opiyo SA, Ateka EM, Owuor PO, Manguro LOA, Miano DW. Development of a multiplex pcr technique for simultaneous detection of sweet potato feathery mottle virus and sweet potato chlorotic stunt virus. Journal of Plant Pathology. 2010;92(2):363-366.
20. Opiyo SA. Repellent Effects of Ocimum Suave Extracts and Compounds against Prostephanus Truncatus Horn. American Journal of Chemistry. 2021;11(2):23-27. doi:doi:10.5923/j.chemistry.20211102.01
21. Opiyo SA. A Review of Insecticidal Plant Extracts and Compounds for Stored Maize Protection. IOSR Journal of Applied Chemistry. 2021;14(10):23-37. doi:doi:10.9790/5736-1410012337
22. Manguro LO, Ogur JA, Opiyo SA. Antimicrobial Constituents Of Conyza Floribunda. WebmedCentral Pharmacol. 2010;1(9):1-11.
23. Manguro LOA, Opiyo SA, Herdtweck E, Lemmen P. Triterpenes of Commiphora holtziana oleo-gum resin. Can J Chem. 2009;87(8):1173-1179. doi:10.1139/V09-078
24. Opiyo SA. Insecticidal Activity of Elaeodendron schweinfurthianum Extracts and Compounds against Sitophilus zeamais Motschulsky. American Journal of Chemistry. 2020;10(3):39-34. doi:doi:10.5923/j.chemistry.2020100
25. Opiyo SA. Insecticidal Activity of Ocimum Suave Willd Extracts and Compounds against Sitophilus Zeamais Motschulsky. Basic Sci Med. 2020;9(2):32-37. doi:doi:10.5923/j.medicine.20200902.03
26. Betseha Y, Woldemariam S, Moges F, Husen A. Antimicrobial activity of crude and semi-purified fractions of Warburgia ugandensis against some pathogens. Journal of Coastal Life Medicine. 2013;3:184-191.
27. Manguro LOA, Opiyo SA, Asefa A, Dagne E, Muchori PW. Chemical Constituents of Essential Oils from Three Eucalyptus Species Acclimatized in Ethiopia and Kenya. Journal of Essential Oil Bearing Plants. 2010;13(5):561-567. doi:10.1080/0972060X.2010.10643863
28. Opiyo SA, Manguro LOA, Owuor PO, Ochieng CO, Ateka EM, Lemmen P. Antimicrobial Compounds from Terminalia brownii against Sweet Potato Pathogens. Nat Prod J. 2011;1(12):116-120. doi:doi:10.2174/2210316311101020116
29. Ochung’ AA, Manguro LAO, Owuor PO, et al. Bioactive carbazole alkaloids from Alysicarpus ovalifolius (Schumach). J Korean Soc Appl Biol Chem. 2015;58(6):839-846. doi:10.1007/s13765-015-0100-4
30. Opiyo SA, Muna, KK, Njoroge PW, Ndirangu EG. Analgesic Activity of Conyza Floribunda Extracts in Swiss Albino Mice. JNSR. 2021;12(12):1-6. doi:10.7176/JNSR/12-12-01
31. Opiyo SA. A Review of Chemical Compounds and Bioactivity of Conyza Species. IOSR-JAC. 2023;16(6):36-48.
32. Opiyo SA, Ateka EM, Owuor PO, Manguro LOA, Karuri HW. Survey of sweet potato viruses in western kenya and detection of cucumber mosaic virus. Journal of Plant Pathology. 2010;92(3):798-801.
33. Ochieng CO, Opiyo SA, Mureka EW, Ishola IO. Cyclooxygenase inhibitory compounds from Gymnosporia heterophylla aerial parts. Fitoterapia. 2017;119:168-174. doi:10.1016/j.fitote.2017.04.015
34. Opiyo S, Njoroge P, Ndirangu E, Kuria K. A Review of Biological Activities and Phytochemistry of Rhus Species. Am J Chem. 2021;11(2):28-36. doi:10.5923/j.chemistry.20211102.02
35. Opiyo SA. A review of 13C NMR spectra of drimane sesquiterpenes. Trends Phytochem Res. 2019;3(3):147-180.
36. Makenzi AM, Manguro LOA, Owuor PO, Opiyo SA. Flavonol glycosides with insecticidal activity from methanol extract of Annona mucosa Jacq. leaves. Trends Phytochem Res. 2019;3(4):287-296. doi:doi:10.1111/jfbc.12913
37. Kuria KM, Opiyo SA. Characterization of Immunogenic Soluble Crude Proteins from Biomphalaria Pfeifferi Against Schistosoma mansoni. JNSR. 2020;10(12):28-34. doi:10.7176/JNSR/10-12-03
38. Maroyi A. Warburgia salutaris (Bertol f) Chiov: A multi-use ethnomedicinal plant species. J Med Plant Res. 2013;7:53-60.
39. Wube AA, Bucar F, Gibbons S, Asres K. Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity. Phytochemistry. 2005;66(19):2309-2315. doi:10.1016/j.phytochem.2005.07.018
40. Kioko JI, Berjak P, Pammenter NW. Responses to dehydration and conservation of the non-orthodox seeds of Warburgia salutaris. South African Journal of Botany. 2003;69(4):532-539. doi:10.1016/s0254-6299(15)30291-x
41. Kariuki PM, Simiyu S. CBCMP Technical report on the Conservation Assessement and Management Planning (CAMP) Workshop, 3 – 5 April 2005 Machakos District, Kenya. Report, IDRC/National Museums of Kenya, Nairobi p34. Published online 2005.
42. Wamalwa NL, Oballa P, Gicheru J. Genetic variation of Warburgia ugandensis in Kenya and implications for its cultivation. Kenya Forestry Research Institution (KEFRI), Nairobi. Published online 2006.
43. Olila D, Opuda-Asibo J, Olwa-Odyek. Bioassay-guided studies on the cytotoxic and in vitro trypanocidal activities of a sesquiterpene (Muzigadial) derived from a Ugandan medicinal plant (Warburgia ugandensis). African health sciences. 2001;1:12-15.
44. Okello D, Komakech R, Matsabisa M, Youngmin K. A review on the botanical aspects, phytochemical contents and pharmacological activities of Warburgia ugandensis. Journal of Medicinal Plants Research. 2018;12:448-455. doi:10.5897/JMPR2018.6626
45. Kaggwa B, Kyeyune H, Munanura EI, et al. Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study. Bourhia M, ed. Evidence-Based Complementary and Alternative Medicine. 2022;2022:1304839. doi:10.1155/2022/1304839
46. Ngure P, Tonui W, Ingonga J, et al. In vitro antileishmanial activity of extracts of Warburgia ugandensis (Canellaceae), a Kenyan medicinal plant. Journal of Medicinal Plants Research. 2009;3.
47. Grieb B, Gebauer J, Mwangi PN. Warburgia Ugandensis -Bioassay of Different Plant Parts Concerning the Antimicrobial Activity. Tropentag. 2011;October:5-7.
48. Karani LW, Tolo FM, Karanja SM, Khayeka−Wandabwa C. Safety of Prunus africana and Warburgia ugandensis in asthma treatment. South African Journal of Botany. 2013;88:183-190. doi:10.1016/j.sajb.2013.07.007
49. Ngure P, Ng’ang’a Z, Kimutai A, et al. Immunostimulatory responses to crude extracts of Warburgia ugandensis (Sprague) subsp ugandensis (Canellaceae) by BALB/c mice infected with Leishmania major. The Pan African medical journal. 2014;17 Suppl 1:15. doi:10.11694/pamj.supp.2014.17.1.3638
50. Were PS, Kutima HL, Suba HO, Walyambillah W. Warburgia ugandensis: A potent in vivo phytomedicine against Plasmodium knowlesi. Journal of Pharmacognosy and Phytochemistry. 2020;9(5):1-5.
51. Abuto J, Muchugi A, Machocho A, Mburu D, Karau M. Variation in Antimicrobial Activity of Warburgia ugandensis Extracts from Different Populations across the Kenyan Rift Valley. Journal of Microbiology Research. 2016;6:55-64.
52. Mbwambo Z, Kazyoba P, Innocent E, Masimba P. Antimicrobial and cytotoxic activities of fresh leaf extracts of Warburgia ugandensis. Tanzania Journal of Health Research (ISSN: 1821-6404) Vol 11 Num 2. 2009;11. doi:10.4314/thrb.v11i2.45205
53. Opiyo SA, Mugendi B, Njoroge PW, Wanjiru SN. A Review of Fatty Acid Components in Avocado. IOSR-JAC. 2023;16(3):18-27.
54. Opiyo SA, Njoroge PW, Kuria KM. Chemical Composition And Biological Activity of Extracts From Conyza Species. IOSR-JAC. 2023;16(4):61-71.
55. Okello D, Gathirwa J, Wanyoko A, et al. Comparative antiplasmodial activity, cytotoxicity, and phytochemical contents of Warburgia ugandensis stem bark against Aspilia africana wild and in vitro regenerated tissues. J Plant Biotechnol. 2023;50(1):97-107. doi:10.5010/JPB.2023.50.013.097
56. Lacroix D, Prado S, Kamoga D, et al. Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda. Journal of ethnopharmacology. 2010;133:850-855. doi:10.1016/j.jep.2010.11.013
57. Nanyingi MO, Kipsengeret KB, Wagate CG. In Vitro and in Vivo Antiplasmodial Activity of Kenyan Medicinal Plants. In: Midiwo JO, Clough J, Eds. Aspects of African Biodiversity. Cambridge: RCS Publishing; 2010.
58. Abd-elfattah M, Maina N, Kareru PG, El-Shemy HA. Antioxidant Potential of Eight selected Kenyan Medicinal plants. Egyptian Journal of Chemistry. 2023;66(1):545-553. doi:10.21608/ejchem.2022.127658.5666
59. Zhuang XC, Zhang Y, Chen GL, et al. Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS. Pharmaceuticals. 2021;14:313. doi:10.3390/ph14040313
60. Zhuang XC, Chen GL, Liu Y, Zhang Y, Guo MQ. New Lignanamides with Antioxidant and Anti-Inflammatory Activities Screened Out and Identified from Warburgia ugandensis Combining Affinity Ultrafiltration LC-MS with SOD and XOD Enzymes. Antioxidants. 2021;10:370. doi:10.3390/antiox10030370
61. Odongo EA. An Ethnobotanical, Antioxidant And Anti-Inflammatory Study Of Medicinal Plants Used In Kakamega County, Western Kenya. In: ; 2016.
62. Taniguchi M, Chapya A, Kubo I, Nakanishi K. Screening of East African plants for antimicrobial activity. Chem Pharm Bull. 1978;26:2910-2913.
63. Drage S, Mitter B, Tröls C, et al. Antimicrobial drimane sesquiterpenes and their effect on endophyte communities in the medical tree Warburgia ugandensis. Frontiers in Microbiology. 2014;5:13.
64. Kamau EW, Mworia EG, Masinde PW, Maingi JM. Studies of Warburgia ugandensis lyophilized crude extract with Trichoderma asperellum on tomato blight pathogens. The Journal of Phytopharmacology. 2021;10(5):385-392.
65. Kipanga PN, Liu M, Panda SK, et al. Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. Journal of Ethnopharmacology. 2020;248:112352. doi:10.1016/j.jep.2019.112352
66. Kraus C, Abou-Ammar R, Schubert A, Fischer M. Warburgia ugandensis Leaf and Bark Extracts: An Alternative to Copper as Fungicide against Downy Mildew in Organic Viticulture? Plants. 2021;10. doi:10.3390/plants10122765
67. Rugutt JK, Ngigi A, Rugutt K, Ndalut PK. Native Kenyan plants as possible alternatives to methyl bromide in soil fumigation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2006;13:576-583. doi:10.1016/j.phymed.2003.08.005
68. Mwitari PG, Ayeka PA, Ondicho J, Matu EN, Bii CC. Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus. PLOS ONE. 2013;8(6):e65619.
69. Ogoti P, Magiri E, Gabriel M, Kariuki D, Bii C. In vitro anti-Salmonella activity of extracts from selected Kenyan medicinal plants. Journal of Medicinal Plants Research. 2015;9:254-261. doi:10.5897/JMPR2014.5497
70. Okoli SJ, Asiimwe S, Mukama AO, Atwiine E, Busobozi A, Kalyetsi R. Antimicrobial Activity of Warburgia ugandensis on Selected Standard Organisms that Cause Urinary Tract Infections. Journal of Advances in Microbiology. 2023;23(3):33-40. doi:10.9734/jamb/2023/v23i3714
71. Oloya B, Namukobe J, Ssengooba W, Afayoa M, Byamukama R. Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda. Tropical Medicine and Health. 2022;50:16. doi:10.1186/s41182-022-00406-7
72. Njire M, Budambula N, Kiiru J. Antimicrobial activity of Warbugia ugandensis against Gram-negative Multi-drug resistant bacteria. Journal of Agriculture, Science and Technology. 2014;16:45-57.
73. Xu M, Litaudon M, Krief S, et al. Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis. Molecules (Basel, Switzerland). 2009;14:3844-3850. doi:10.3390/molecules14103844
74. Githinji E, Irungu L, Tonui W, et al. In Vitro Effects of Warburgia Ugandensis, Psiadia Punctulata and Chasmanthera Dependens on Leishmania Major Promastigotes. African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines. 2010;7:264-275. doi:10.4314/ajtcam.v7i3.54791
75. Kitte R, Tretbar M, Dluczek S, et al. Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis. Results in Chemistry. 2021;3:100242. doi:10.1016/j.rechem.2021.100242
76. Zhang Y, Chen G, Zhuang X, Guo M. Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G0/G1 Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation. Oxidative Medicine and Cellular Longevity. 2021;2021:1-11. doi:10.1155/2021/8807676
77. Debella A, Taye A, Abebe DS, Mudi K, Melaku D, Taye G. Screening of some Ethiopian medicinal plants for mosquito larvicidal effects and phytochemical constituents. Pharmacologyonline 2007;3:231-243
78. Kaguchia M, Sm K, Sm G, Cl T, Birgen J. Bioefficacy of Selected Plant Extracts against Sitophilus zeamais on Post-Harvest Management of Zea mays. Journal of Phytopharmacology. 2018;7:384-391. doi:10.31254/phyto.2018.7406
79. Opiyo SA, Manguro LOA, Okoth DA, Ochung AA, Ochieng CO. Biopesticidal Extractives and Compounds from Warburgia ugandensis against Maize Weevil (Sitophilus zeamais). NPJ. 2015;5(4):236-243. doi:10.2174/2210315505666150916000539
80. Opiyo SA. Insecticidal Drimane Sesquiterpenes from Warburgia ugandensis against Maize Pests. American Journal of Chemistry. 2021;11(4):59-65. doi:doi:10.5923/j.chemistry.20211104.01
81. Matura JAN, Walekhwa MN, Otieno FO. Larvicidal activity of the methanolic extract of Warburgia ugandensis seed oil on Aedes aegypti. Journal of Science, Innovation and Creativity. 2022;1(1):1-9.
82. Liu M, Kipanga PN, Mai AH, et al. Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial. International journal for parasitology. 2018;48 11:833-844.
83. Kioy D, Gray AI, Waterman PG. A comparative study of the stem-bark drimane sesquiterpenes and leaf volatile oils of Warburgia ugandensis and W. Stuhlmannii. Phytochemistry. 1990;29(11):3535-3538. doi:10.1016/0031-9422(90)85270-P
84. Opiyo SA, Manguro LOA, Okinda-Owuor P, Ateka EM, Lemmen P. 7α-Acetylugandensolide and antimicrobial properties of Warburgia ugandensis extracts and isolates against sweet potato pathogens. Phytochemistry Letters. 2011;4(2):161-165. doi:10.1016/j.phytol.2011.02.007
85. Kubo I, Lee YW, Pettei M, Pilkiewicz F, Nakanishi K. Potent armyworm anti feedants from the east african warburgia plants. Journal of the Chemical Society Chemical Communications. 1976;24:1013-1014.
86. Opiyo SA. Detection of sweet potato viruses in western Kenya, development of a multiplex PCR technique for simultaneous detection of major viruses and evaluation of medicinal plants for antifungal and antibacterial activities against the crop pathogens. PhD thesis. Maseno University, Kenya; 2011.
87. Rajab M, Ndegwa JM. 11α-Hydroxy muzigadiolide, a novel drimane sesquiterpene from the stem bark of warburgia ugandensis. Bulletin of the Chemical Society of Ethiopia. 2000;14. doi:10.4314/bcse.v14i1.71998
88. Gonfa T. Isolation and Characterization of Sesquiterpenes from Stem Bark of Warburgia ugandensis Sprague. Biology, Medicine, & Natural Product Chemistry. 2020;9. doi:10.14421/biomedich.2020.91.39-46
89. Montenegro I, Tomasoni G, Bosio C, et al. Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines. Molecules. 2014;19:18993-19006. doi:10.3390/molecules191118993
90. Kuglerova M, Tesarova H, Gradé JT, et al. Antimicrobial and antioxidative effects of Ugandan medicinal barks. African Journal of Biotechnology. 2011;10:3628-3632.
91. Onguéné PA, Ntie-Kang F, Lifongo LL, Ndom JC, Sippl W, Mbaze LM. The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids. Malaria Journal. 2013;12(1):449. doi:10.1186/1475-2875-12-449
92. Manguro LOA, Ugi I, Lemmen P, Hermann R. Flavonol glycosides of Warburgia ugandensis leaves. Phytochemistry. 2003;64(4):891-896. doi:10.1016/S0031-9422(03)00374-1
93. Somsak V, Damkaew A, Onrak P. Antimalarial Activity of Kaempferol and Its Combination with Chloroquine in Plasmodium berghei Infection in Mice. Journal of Pathogens. 2018;2018:1-7. doi:10.1155/2018/3912090
94. Alam W, Khan H, Shah MA, Cauli O, Saso L. Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing. Molecules. 2020;25(18). doi:10.3390/molecules25184073
95. Sharma N, Biswas S, Al-Dayan N, Alhegaili A, Sarwat M. Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma. Antioxidants. 2021;10:1419. doi:10.3390/antiox10091419
96. Jin MI, Bae KH, Chang H, Son J. Anti-inflammatory Compounds from the Leaves of Ailanthus altissima Meihua JIN. Biomolecules & Therapeutics. 2009;17:86-91. doi:10.4062/biomolther.2009.17.1.86
97. Ivanov M, Kannan A, Stojković D, et al. Revealing the astragalin mode of anticandidal action. EXCLI journal. 2020;19:1436-1445. doi:10.17179/excli2020-2987
98. Lantovololona J, Talontsi F, Randriambola L, Laatsch H. Radical-Scavenging Activity, Cytotoxicity and Chemical Constituents of Euphorbia orthoclada from Madagascar. The Natural Products Journal. 2013;3:77-80. doi:10.2174/2210315511303010014
99. Akter M, Parvin M, Hasan M, Rahman A, Islam M. Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves. BMC Complementary Medicine and Therapies. 2022;22. doi:10.1186/s12906-022-03633-x
100. Nascimento LB, Casanova LM, Costa SS. Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs. Life. 2023;13(3). doi:10.3390/life13030646
101. Hong HK, Kwak JH, Kang SC, et al. Antioxidative constituents from the whole plants of Euphorbia supina. Korean Journal of Pharmacognosy. 2008;39:260-264.
102. Zhao J, Zhang S, You S, et al. Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A-Induced and D-Galactosamine-Induced Liver Injury in Mice. International Journal of Molecular Sciences. 2017;18(3). doi:10.3390/ijms18030587
103. Wang J, Fang X, Ge L, et al. Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol. PLOS ONE. 2018;13:e0197563. doi:10.1371/journal.pone.0197563
104. Lescano CH, Freitas de Lima F, Caires ARL, de Oliveira IP. Chapter 25 - Polyphenols Present in Campomanesia Genus: Pharmacological and Nutraceutical Approach. In: Watson RR, ed. Polyphenols in Plants (Second Edition). Academic Press; 2019:407-420. doi:10.1016/B978-0-12-813768-0.00027-X
105. Taheri Y, Suleria HAR, Martins N, et al. Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications. BMC Complementary Medicine and Therapies. 2020;20(1):241.
106. Hayder N, Bouhlel I, Skandrani I, et al. . In vitro antioxidant and antigenotoxic potentials of myricetin-3-O-galactoside and myricetin-3-O-rhamnoside from Myrtus communis:modulation of expression of genes involved in cell defence system using cDNA microarray. Toxicology in vitro : an international journal published in association with BIBRA. 2008;22:567-581. doi:10.1016/j.tiv.2007.11.015
107. Aderogba M, Ndhlala A, Rengasamy K, van Staden J. Antimicrobial and Selected In Vitro Enzyme Inhibitory Effects of Leaf Extracts, Flavonols and Indole Alkaloids Isolated from Croton menyharthii. Molecules (Basel, Switzerland). 2013;18:12633-12644. doi:10.3390/molecules181012633
108. Nugroho A, Heryani H, Choi J, Park HJ. Identification and quantification of flavonoids in Carica papaya leaf and peroxynitrite-scavenging activity. Asian Pacific Journal of Tropical Biomedicine. 2016;7. doi:10.1016/j.apjtb.2016.12.009
109. Elloumi W, Mahmoudi A, Ortiz S, Boutefnouchet S, Chamkha M, Sayadi S. Wound healing potential of quercetin-3-O-rhamnoside and myricetin-3-O-rhamnoside isolated from Pistacia lentiscus distilled leaves in rats model. Biomedicine & Pharmacotherapy. 2022;146:112574. doi:10.1016/j.biopha.2021.112574
110. Qi W, Qi W, Xiong D, Long M. Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy. Molecules. 2022;27(19). doi:10.3390/molecules27196545
111. Yun J, Woo ER, Lee DG. Effect of isoquercitrin on membrane dynamics and apoptosis-like death in Escherichia coli. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2018;1860(2):357-363. doi:10.1016/j.bbamem.2017.11.008
112. Bokelmann JM. 71 - Stinging Nettle/Nettles/Nettle (Urtica dioica, Urtica urens): Leaf, Root. In: Bokelmann JM, ed. Medicinal Herbs in Primary Care. Elsevier; 2022:599-607.
113. Lesjak M, Beara I, Simin N, et al. Antioxidant and anti-inflammatory activities of quercetin and its derivatives. Journal of Functional Foods. 2018;40:68-75.
114. Ezenyi IC, Salawu OA, Kulkarni R, Emeje M. Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum. Parasitology Research. 2014;113(12):4415-4422.
2. Kokwaro JO. Medicinal Plants of East Africa. 3rd ed. University of Nairobi Press; 2009.
3. Jeruto P, Arama P, Anyango B, Nyunja R, Taracha C, Opiyo S. Morphometric Study of Senna didymobotrya (Fresen.) H. S. Irwin and Barneby in Kenya. J Nat Sci Res. 2017;7:54-69.
4. Opiyo S. Stored Grains Protection Activity of Ocimum Suave Extracts and Compounds on Larger Grain Borer. IOSR Journal of Biotechnology and Biochemistry. 2022;8(4):5-10. doi:10.9790/264X-08040510
5. Ndirangu EG, Opiyo SA, Ng’ang’a MW. Chemical composition and repellency of Nigella sativa L. seed essential oil against Anopheles gambiae sensu stricto. Trends Phytochem Res. 2020;4(2):77-84.
6. Njoroge PW, Opiyo SA. Antimicrobial Activity of Root Bark Extracts of Rhus natalensisa and Rhus ruspolii. Basic Sciences of Medicine. 2019;8(2):23-28. doi:doi:10.5923/j.medicine.20190802.01
7. Ochieng C, Ishola I, Opiyo S, Manguro L, Owuor P, Wong KC. Phytoecdysteroids from the Stem Bark of Vitex doniana and Their Anti-Inflammatory Effects. Planta Med. 2013;79(1):52-59. doi:10.1055/s-0032-1327880
8. Opiyo SA, Manguro LOA, Owuor PO, Ateka EM. Triterpenes from Elaeodendron schweinfurthianum and Their Antimicrobial Activities against Crop Pathogens. American Journal of Chemistry. 2017;7(3):97-104. doi:doi:10.5923/j.chemistry.20170703.03
9. Opiyo SA, Manguro LO, Ogur J, Wagai S. Bioactive Constituents of Conyza floribunda. Research Journal of Pharmacology. 2010;4(3):55-59. doi:10.3923/rjpharm.2010.55.59
10. Opiyo SA. Evaluation of Warburgia ugandensis Extracts and Compounds for Crop Protection against Prostephanus truncates. Advances in Analytical Chemistry. 2020;10(2):15-19. doi:doi:10.5923/j.aac.20201002.01
11. Opiyo SA. Triterpenes and Sterols from Ocimum suave. IOSR J Appl Chem. 2022;15(7):1-6. doi:doi:10.9790/5736-1507010106
12. Ochung AA, Owuor PO, Manguro LAO, et al. Analgesics from Lonchocarpus eriocalyx Harms. Trends Phytochem Res. 2018;2(4):253-260.
13. Ndirangu EG, Opiyo SA, Ng’ang’a MW. Repellent Properties of Compounds and Blends from Nigella sativa Seeds Against Anopheles gambiae. Basic Sciences of Medicine. 2020;9(1):1-7. doi:doi:10.5923/j.medicine.20200901.01
14. Opiyo SA, Ogur JA, Manguro LOA, Tietze LF, Schuster H. A New Sterol Diglycoside from Conyza floribunda. S Afr J Chem. 2009;62:163-167.
15. Njoroge PW, Opiyo SA. Some Antibacterial and Antifungal Compounds from Root Bark of Rhus natalensis. American Journal of Chemistry. 2019;9(5):150-158. doi:doi:10.5923/j.chemistry.20190905.03
16. Makenzi AM, Manguro LOA, Owuor PO, Opiyo SA. Chemical constituents of Ocimum kilimandscharicum Guerke acclimatized in Kakamega Forest, Kenya. Bull Chem Soc Eth. 2019;33(3):527. doi:10.4314/bcse.v33i3.13
17. Opiyo SA. Chemical Composition of Essential Oils from Ocimum Kilimandscharicum: A Review. IOSR Journal of Applied Chemistry. 2022;15(11):5-11.
18. Opiyo SA, Njoroge PW, Ndirangu EG. A Review Pesticidal Activity of Essential Oils against Sitophilus oryzae, Sitophilus granaries and Sitophilus Zeamais. IOSR J Appl Chem. 2022;15(4):39-51. doi:doi:10.9790/5736-1504013951
19. Opiyo SA, Ateka EM, Owuor PO, Manguro LOA, Miano DW. Development of a multiplex pcr technique for simultaneous detection of sweet potato feathery mottle virus and sweet potato chlorotic stunt virus. Journal of Plant Pathology. 2010;92(2):363-366.
20. Opiyo SA. Repellent Effects of Ocimum Suave Extracts and Compounds against Prostephanus Truncatus Horn. American Journal of Chemistry. 2021;11(2):23-27. doi:doi:10.5923/j.chemistry.20211102.01
21. Opiyo SA. A Review of Insecticidal Plant Extracts and Compounds for Stored Maize Protection. IOSR Journal of Applied Chemistry. 2021;14(10):23-37. doi:doi:10.9790/5736-1410012337
22. Manguro LO, Ogur JA, Opiyo SA. Antimicrobial Constituents Of Conyza Floribunda. WebmedCentral Pharmacol. 2010;1(9):1-11.
23. Manguro LOA, Opiyo SA, Herdtweck E, Lemmen P. Triterpenes of Commiphora holtziana oleo-gum resin. Can J Chem. 2009;87(8):1173-1179. doi:10.1139/V09-078
24. Opiyo SA. Insecticidal Activity of Elaeodendron schweinfurthianum Extracts and Compounds against Sitophilus zeamais Motschulsky. American Journal of Chemistry. 2020;10(3):39-34. doi:doi:10.5923/j.chemistry.2020100
25. Opiyo SA. Insecticidal Activity of Ocimum Suave Willd Extracts and Compounds against Sitophilus Zeamais Motschulsky. Basic Sci Med. 2020;9(2):32-37. doi:doi:10.5923/j.medicine.20200902.03
26. Betseha Y, Woldemariam S, Moges F, Husen A. Antimicrobial activity of crude and semi-purified fractions of Warburgia ugandensis against some pathogens. Journal of Coastal Life Medicine. 2013;3:184-191.
27. Manguro LOA, Opiyo SA, Asefa A, Dagne E, Muchori PW. Chemical Constituents of Essential Oils from Three Eucalyptus Species Acclimatized in Ethiopia and Kenya. Journal of Essential Oil Bearing Plants. 2010;13(5):561-567. doi:10.1080/0972060X.2010.10643863
28. Opiyo SA, Manguro LOA, Owuor PO, Ochieng CO, Ateka EM, Lemmen P. Antimicrobial Compounds from Terminalia brownii against Sweet Potato Pathogens. Nat Prod J. 2011;1(12):116-120. doi:doi:10.2174/2210316311101020116
29. Ochung’ AA, Manguro LAO, Owuor PO, et al. Bioactive carbazole alkaloids from Alysicarpus ovalifolius (Schumach). J Korean Soc Appl Biol Chem. 2015;58(6):839-846. doi:10.1007/s13765-015-0100-4
30. Opiyo SA, Muna, KK, Njoroge PW, Ndirangu EG. Analgesic Activity of Conyza Floribunda Extracts in Swiss Albino Mice. JNSR. 2021;12(12):1-6. doi:10.7176/JNSR/12-12-01
31. Opiyo SA. A Review of Chemical Compounds and Bioactivity of Conyza Species. IOSR-JAC. 2023;16(6):36-48.
32. Opiyo SA, Ateka EM, Owuor PO, Manguro LOA, Karuri HW. Survey of sweet potato viruses in western kenya and detection of cucumber mosaic virus. Journal of Plant Pathology. 2010;92(3):798-801.
33. Ochieng CO, Opiyo SA, Mureka EW, Ishola IO. Cyclooxygenase inhibitory compounds from Gymnosporia heterophylla aerial parts. Fitoterapia. 2017;119:168-174. doi:10.1016/j.fitote.2017.04.015
34. Opiyo S, Njoroge P, Ndirangu E, Kuria K. A Review of Biological Activities and Phytochemistry of Rhus Species. Am J Chem. 2021;11(2):28-36. doi:10.5923/j.chemistry.20211102.02
35. Opiyo SA. A review of 13C NMR spectra of drimane sesquiterpenes. Trends Phytochem Res. 2019;3(3):147-180.
36. Makenzi AM, Manguro LOA, Owuor PO, Opiyo SA. Flavonol glycosides with insecticidal activity from methanol extract of Annona mucosa Jacq. leaves. Trends Phytochem Res. 2019;3(4):287-296. doi:doi:10.1111/jfbc.12913
37. Kuria KM, Opiyo SA. Characterization of Immunogenic Soluble Crude Proteins from Biomphalaria Pfeifferi Against Schistosoma mansoni. JNSR. 2020;10(12):28-34. doi:10.7176/JNSR/10-12-03
38. Maroyi A. Warburgia salutaris (Bertol f) Chiov: A multi-use ethnomedicinal plant species. J Med Plant Res. 2013;7:53-60.
39. Wube AA, Bucar F, Gibbons S, Asres K. Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity. Phytochemistry. 2005;66(19):2309-2315. doi:10.1016/j.phytochem.2005.07.018
40. Kioko JI, Berjak P, Pammenter NW. Responses to dehydration and conservation of the non-orthodox seeds of Warburgia salutaris. South African Journal of Botany. 2003;69(4):532-539. doi:10.1016/s0254-6299(15)30291-x
41. Kariuki PM, Simiyu S. CBCMP Technical report on the Conservation Assessement and Management Planning (CAMP) Workshop, 3 – 5 April 2005 Machakos District, Kenya. Report, IDRC/National Museums of Kenya, Nairobi p34. Published online 2005.
42. Wamalwa NL, Oballa P, Gicheru J. Genetic variation of Warburgia ugandensis in Kenya and implications for its cultivation. Kenya Forestry Research Institution (KEFRI), Nairobi. Published online 2006.
43. Olila D, Opuda-Asibo J, Olwa-Odyek. Bioassay-guided studies on the cytotoxic and in vitro trypanocidal activities of a sesquiterpene (Muzigadial) derived from a Ugandan medicinal plant (Warburgia ugandensis). African health sciences. 2001;1:12-15.
44. Okello D, Komakech R, Matsabisa M, Youngmin K. A review on the botanical aspects, phytochemical contents and pharmacological activities of Warburgia ugandensis. Journal of Medicinal Plants Research. 2018;12:448-455. doi:10.5897/JMPR2018.6626
45. Kaggwa B, Kyeyune H, Munanura EI, et al. Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study. Bourhia M, ed. Evidence-Based Complementary and Alternative Medicine. 2022;2022:1304839. doi:10.1155/2022/1304839
46. Ngure P, Tonui W, Ingonga J, et al. In vitro antileishmanial activity of extracts of Warburgia ugandensis (Canellaceae), a Kenyan medicinal plant. Journal of Medicinal Plants Research. 2009;3.
47. Grieb B, Gebauer J, Mwangi PN. Warburgia Ugandensis -Bioassay of Different Plant Parts Concerning the Antimicrobial Activity. Tropentag. 2011;October:5-7.
48. Karani LW, Tolo FM, Karanja SM, Khayeka−Wandabwa C. Safety of Prunus africana and Warburgia ugandensis in asthma treatment. South African Journal of Botany. 2013;88:183-190. doi:10.1016/j.sajb.2013.07.007
49. Ngure P, Ng’ang’a Z, Kimutai A, et al. Immunostimulatory responses to crude extracts of Warburgia ugandensis (Sprague) subsp ugandensis (Canellaceae) by BALB/c mice infected with Leishmania major. The Pan African medical journal. 2014;17 Suppl 1:15. doi:10.11694/pamj.supp.2014.17.1.3638
50. Were PS, Kutima HL, Suba HO, Walyambillah W. Warburgia ugandensis: A potent in vivo phytomedicine against Plasmodium knowlesi. Journal of Pharmacognosy and Phytochemistry. 2020;9(5):1-5.
51. Abuto J, Muchugi A, Machocho A, Mburu D, Karau M. Variation in Antimicrobial Activity of Warburgia ugandensis Extracts from Different Populations across the Kenyan Rift Valley. Journal of Microbiology Research. 2016;6:55-64.
52. Mbwambo Z, Kazyoba P, Innocent E, Masimba P. Antimicrobial and cytotoxic activities of fresh leaf extracts of Warburgia ugandensis. Tanzania Journal of Health Research (ISSN: 1821-6404) Vol 11 Num 2. 2009;11. doi:10.4314/thrb.v11i2.45205
53. Opiyo SA, Mugendi B, Njoroge PW, Wanjiru SN. A Review of Fatty Acid Components in Avocado. IOSR-JAC. 2023;16(3):18-27.
54. Opiyo SA, Njoroge PW, Kuria KM. Chemical Composition And Biological Activity of Extracts From Conyza Species. IOSR-JAC. 2023;16(4):61-71.
55. Okello D, Gathirwa J, Wanyoko A, et al. Comparative antiplasmodial activity, cytotoxicity, and phytochemical contents of Warburgia ugandensis stem bark against Aspilia africana wild and in vitro regenerated tissues. J Plant Biotechnol. 2023;50(1):97-107. doi:10.5010/JPB.2023.50.013.097
56. Lacroix D, Prado S, Kamoga D, et al. Antiplasmodial and cytotoxic activities of medicinal plants traditionally used in the village of Kiohima, Uganda. Journal of ethnopharmacology. 2010;133:850-855. doi:10.1016/j.jep.2010.11.013
57. Nanyingi MO, Kipsengeret KB, Wagate CG. In Vitro and in Vivo Antiplasmodial Activity of Kenyan Medicinal Plants. In: Midiwo JO, Clough J, Eds. Aspects of African Biodiversity. Cambridge: RCS Publishing; 2010.
58. Abd-elfattah M, Maina N, Kareru PG, El-Shemy HA. Antioxidant Potential of Eight selected Kenyan Medicinal plants. Egyptian Journal of Chemistry. 2023;66(1):545-553. doi:10.21608/ejchem.2022.127658.5666
59. Zhuang XC, Zhang Y, Chen GL, et al. Identification of Anti-Inflammatory and Anti-Proliferative Neolignanamides from Warburgia ugandensis Employing Multi-Target Affinity Ultrafiltration and LC-MS. Pharmaceuticals. 2021;14:313. doi:10.3390/ph14040313
60. Zhuang XC, Chen GL, Liu Y, Zhang Y, Guo MQ. New Lignanamides with Antioxidant and Anti-Inflammatory Activities Screened Out and Identified from Warburgia ugandensis Combining Affinity Ultrafiltration LC-MS with SOD and XOD Enzymes. Antioxidants. 2021;10:370. doi:10.3390/antiox10030370
61. Odongo EA. An Ethnobotanical, Antioxidant And Anti-Inflammatory Study Of Medicinal Plants Used In Kakamega County, Western Kenya. In: ; 2016.
62. Taniguchi M, Chapya A, Kubo I, Nakanishi K. Screening of East African plants for antimicrobial activity. Chem Pharm Bull. 1978;26:2910-2913.
63. Drage S, Mitter B, Tröls C, et al. Antimicrobial drimane sesquiterpenes and their effect on endophyte communities in the medical tree Warburgia ugandensis. Frontiers in Microbiology. 2014;5:13.
64. Kamau EW, Mworia EG, Masinde PW, Maingi JM. Studies of Warburgia ugandensis lyophilized crude extract with Trichoderma asperellum on tomato blight pathogens. The Journal of Phytopharmacology. 2021;10(5):385-392.
65. Kipanga PN, Liu M, Panda SK, et al. Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. Journal of Ethnopharmacology. 2020;248:112352. doi:10.1016/j.jep.2019.112352
66. Kraus C, Abou-Ammar R, Schubert A, Fischer M. Warburgia ugandensis Leaf and Bark Extracts: An Alternative to Copper as Fungicide against Downy Mildew in Organic Viticulture? Plants. 2021;10. doi:10.3390/plants10122765
67. Rugutt JK, Ngigi A, Rugutt K, Ndalut PK. Native Kenyan plants as possible alternatives to methyl bromide in soil fumigation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2006;13:576-583. doi:10.1016/j.phymed.2003.08.005
68. Mwitari PG, Ayeka PA, Ondicho J, Matu EN, Bii CC. Antimicrobial Activity and Probable Mechanisms of Action of Medicinal Plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus. PLOS ONE. 2013;8(6):e65619.
69. Ogoti P, Magiri E, Gabriel M, Kariuki D, Bii C. In vitro anti-Salmonella activity of extracts from selected Kenyan medicinal plants. Journal of Medicinal Plants Research. 2015;9:254-261. doi:10.5897/JMPR2014.5497
70. Okoli SJ, Asiimwe S, Mukama AO, Atwiine E, Busobozi A, Kalyetsi R. Antimicrobial Activity of Warburgia ugandensis on Selected Standard Organisms that Cause Urinary Tract Infections. Journal of Advances in Microbiology. 2023;23(3):33-40. doi:10.9734/jamb/2023/v23i3714
71. Oloya B, Namukobe J, Ssengooba W, Afayoa M, Byamukama R. Phytochemical screening, antimycobacterial activity and acute toxicity of crude extracts of selected medicinal plant species used locally in the treatment of tuberculosis in Uganda. Tropical Medicine and Health. 2022;50:16. doi:10.1186/s41182-022-00406-7
72. Njire M, Budambula N, Kiiru J. Antimicrobial activity of Warbugia ugandensis against Gram-negative Multi-drug resistant bacteria. Journal of Agriculture, Science and Technology. 2014;16:45-57.
73. Xu M, Litaudon M, Krief S, et al. Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis. Molecules (Basel, Switzerland). 2009;14:3844-3850. doi:10.3390/molecules14103844
74. Githinji E, Irungu L, Tonui W, et al. In Vitro Effects of Warburgia Ugandensis, Psiadia Punctulata and Chasmanthera Dependens on Leishmania Major Promastigotes. African journal of traditional, complementary, and alternative medicines : AJTCAM / African Networks on Ethnomedicines. 2010;7:264-275. doi:10.4314/ajtcam.v7i3.54791
75. Kitte R, Tretbar M, Dluczek S, et al. Chemical and Cytotoxic Activity of three main Sesquiterpenoids from Warburgia ugandensis. Results in Chemistry. 2021;3:100242. doi:10.1016/j.rechem.2021.100242
76. Zhang Y, Chen G, Zhuang X, Guo M. Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G0/G1 Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation. Oxidative Medicine and Cellular Longevity. 2021;2021:1-11. doi:10.1155/2021/8807676
77. Debella A, Taye A, Abebe DS, Mudi K, Melaku D, Taye G. Screening of some Ethiopian medicinal plants for mosquito larvicidal effects and phytochemical constituents. Pharmacologyonline 2007;3:231-243
78. Kaguchia M, Sm K, Sm G, Cl T, Birgen J. Bioefficacy of Selected Plant Extracts against Sitophilus zeamais on Post-Harvest Management of Zea mays. Journal of Phytopharmacology. 2018;7:384-391. doi:10.31254/phyto.2018.7406
79. Opiyo SA, Manguro LOA, Okoth DA, Ochung AA, Ochieng CO. Biopesticidal Extractives and Compounds from Warburgia ugandensis against Maize Weevil (Sitophilus zeamais). NPJ. 2015;5(4):236-243. doi:10.2174/2210315505666150916000539
80. Opiyo SA. Insecticidal Drimane Sesquiterpenes from Warburgia ugandensis against Maize Pests. American Journal of Chemistry. 2021;11(4):59-65. doi:doi:10.5923/j.chemistry.20211104.01
81. Matura JAN, Walekhwa MN, Otieno FO. Larvicidal activity of the methanolic extract of Warburgia ugandensis seed oil on Aedes aegypti. Journal of Science, Innovation and Creativity. 2022;1(1):1-9.
82. Liu M, Kipanga PN, Mai AH, et al. Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial. International journal for parasitology. 2018;48 11:833-844.
83. Kioy D, Gray AI, Waterman PG. A comparative study of the stem-bark drimane sesquiterpenes and leaf volatile oils of Warburgia ugandensis and W. Stuhlmannii. Phytochemistry. 1990;29(11):3535-3538. doi:10.1016/0031-9422(90)85270-P
84. Opiyo SA, Manguro LOA, Okinda-Owuor P, Ateka EM, Lemmen P. 7α-Acetylugandensolide and antimicrobial properties of Warburgia ugandensis extracts and isolates against sweet potato pathogens. Phytochemistry Letters. 2011;4(2):161-165. doi:10.1016/j.phytol.2011.02.007
85. Kubo I, Lee YW, Pettei M, Pilkiewicz F, Nakanishi K. Potent armyworm anti feedants from the east african warburgia plants. Journal of the Chemical Society Chemical Communications. 1976;24:1013-1014.
86. Opiyo SA. Detection of sweet potato viruses in western Kenya, development of a multiplex PCR technique for simultaneous detection of major viruses and evaluation of medicinal plants for antifungal and antibacterial activities against the crop pathogens. PhD thesis. Maseno University, Kenya; 2011.
87. Rajab M, Ndegwa JM. 11α-Hydroxy muzigadiolide, a novel drimane sesquiterpene from the stem bark of warburgia ugandensis. Bulletin of the Chemical Society of Ethiopia. 2000;14. doi:10.4314/bcse.v14i1.71998
88. Gonfa T. Isolation and Characterization of Sesquiterpenes from Stem Bark of Warburgia ugandensis Sprague. Biology, Medicine, & Natural Product Chemistry. 2020;9. doi:10.14421/biomedich.2020.91.39-46
89. Montenegro I, Tomasoni G, Bosio C, et al. Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines. Molecules. 2014;19:18993-19006. doi:10.3390/molecules191118993
90. Kuglerova M, Tesarova H, Gradé JT, et al. Antimicrobial and antioxidative effects of Ugandan medicinal barks. African Journal of Biotechnology. 2011;10:3628-3632.
91. Onguéné PA, Ntie-Kang F, Lifongo LL, Ndom JC, Sippl W, Mbaze LM. The potential of anti-malarial compounds derived from African medicinal plants. Part I: A pharmacological evaluation of alkaloids and terpenoids. Malaria Journal. 2013;12(1):449. doi:10.1186/1475-2875-12-449
92. Manguro LOA, Ugi I, Lemmen P, Hermann R. Flavonol glycosides of Warburgia ugandensis leaves. Phytochemistry. 2003;64(4):891-896. doi:10.1016/S0031-9422(03)00374-1
93. Somsak V, Damkaew A, Onrak P. Antimalarial Activity of Kaempferol and Its Combination with Chloroquine in Plasmodium berghei Infection in Mice. Journal of Pathogens. 2018;2018:1-7. doi:10.1155/2018/3912090
94. Alam W, Khan H, Shah MA, Cauli O, Saso L. Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing. Molecules. 2020;25(18). doi:10.3390/molecules25184073
95. Sharma N, Biswas S, Al-Dayan N, Alhegaili A, Sarwat M. Antioxidant Role of Kaempferol in Prevention of Hepatocellular Carcinoma. Antioxidants. 2021;10:1419. doi:10.3390/antiox10091419
96. Jin MI, Bae KH, Chang H, Son J. Anti-inflammatory Compounds from the Leaves of Ailanthus altissima Meihua JIN. Biomolecules & Therapeutics. 2009;17:86-91. doi:10.4062/biomolther.2009.17.1.86
97. Ivanov M, Kannan A, Stojković D, et al. Revealing the astragalin mode of anticandidal action. EXCLI journal. 2020;19:1436-1445. doi:10.17179/excli2020-2987
98. Lantovololona J, Talontsi F, Randriambola L, Laatsch H. Radical-Scavenging Activity, Cytotoxicity and Chemical Constituents of Euphorbia orthoclada from Madagascar. The Natural Products Journal. 2013;3:77-80. doi:10.2174/2210315511303010014
99. Akter M, Parvin M, Hasan M, Rahman A, Islam M. Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves. BMC Complementary Medicine and Therapies. 2022;22. doi:10.1186/s12906-022-03633-x
100. Nascimento LB, Casanova LM, Costa SS. Bioactive Compounds from Kalanchoe Genus Potentially Useful for the Development of New Drugs. Life. 2023;13(3). doi:10.3390/life13030646
101. Hong HK, Kwak JH, Kang SC, et al. Antioxidative constituents from the whole plants of Euphorbia supina. Korean Journal of Pharmacognosy. 2008;39:260-264.
102. Zhao J, Zhang S, You S, et al. Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A-Induced and D-Galactosamine-Induced Liver Injury in Mice. International Journal of Molecular Sciences. 2017;18(3). doi:10.3390/ijms18030587
103. Wang J, Fang X, Ge L, et al. Antitumor, antioxidant and anti-inflammatory activities of kaempferol and its corresponding glycosides and the enzymatic preparation of kaempferol. PLOS ONE. 2018;13:e0197563. doi:10.1371/journal.pone.0197563
104. Lescano CH, Freitas de Lima F, Caires ARL, de Oliveira IP. Chapter 25 - Polyphenols Present in Campomanesia Genus: Pharmacological and Nutraceutical Approach. In: Watson RR, ed. Polyphenols in Plants (Second Edition). Academic Press; 2019:407-420. doi:10.1016/B978-0-12-813768-0.00027-X
105. Taheri Y, Suleria HAR, Martins N, et al. Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications. BMC Complementary Medicine and Therapies. 2020;20(1):241.
106. Hayder N, Bouhlel I, Skandrani I, et al. . In vitro antioxidant and antigenotoxic potentials of myricetin-3-O-galactoside and myricetin-3-O-rhamnoside from Myrtus communis:modulation of expression of genes involved in cell defence system using cDNA microarray. Toxicology in vitro : an international journal published in association with BIBRA. 2008;22:567-581. doi:10.1016/j.tiv.2007.11.015
107. Aderogba M, Ndhlala A, Rengasamy K, van Staden J. Antimicrobial and Selected In Vitro Enzyme Inhibitory Effects of Leaf Extracts, Flavonols and Indole Alkaloids Isolated from Croton menyharthii. Molecules (Basel, Switzerland). 2013;18:12633-12644. doi:10.3390/molecules181012633
108. Nugroho A, Heryani H, Choi J, Park HJ. Identification and quantification of flavonoids in Carica papaya leaf and peroxynitrite-scavenging activity. Asian Pacific Journal of Tropical Biomedicine. 2016;7. doi:10.1016/j.apjtb.2016.12.009
109. Elloumi W, Mahmoudi A, Ortiz S, Boutefnouchet S, Chamkha M, Sayadi S. Wound healing potential of quercetin-3-O-rhamnoside and myricetin-3-O-rhamnoside isolated from Pistacia lentiscus distilled leaves in rats model. Biomedicine & Pharmacotherapy. 2022;146:112574. doi:10.1016/j.biopha.2021.112574
110. Qi W, Qi W, Xiong D, Long M. Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy. Molecules. 2022;27(19). doi:10.3390/molecules27196545
111. Yun J, Woo ER, Lee DG. Effect of isoquercitrin on membrane dynamics and apoptosis-like death in Escherichia coli. Biochimica et Biophysica Acta (BBA) - Biomembranes. 2018;1860(2):357-363. doi:10.1016/j.bbamem.2017.11.008
112. Bokelmann JM. 71 - Stinging Nettle/Nettles/Nettle (Urtica dioica, Urtica urens): Leaf, Root. In: Bokelmann JM, ed. Medicinal Herbs in Primary Care. Elsevier; 2022:599-607.
113. Lesjak M, Beara I, Simin N, et al. Antioxidant and anti-inflammatory activities of quercetin and its derivatives. Journal of Functional Foods. 2018;40:68-75.
114. Ezenyi IC, Salawu OA, Kulkarni R, Emeje M. Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum. Parasitology Research. 2014;113(12):4415-4422.
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30/06/2023
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Opiyo, S. “Warburgia Ugandensis: A Review of Compounds and Bioactivity”. International Journal of Pharmacognosy and Chemistry, Vol. 4, no. 2, June 2023, pp. 35-45, doi:10.46796/ijpc.v4i2.457.
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