A current study on pharmacology and phytochemistry of biophytum sensitivum
Abstract
Biophytum sensitivum (L.) DC, a highly valuable medicinal herb from the Daspushpam category of Ayurvedic essential plants in the Oxalidaceae family. It is also called as, little tree plant, life plant and sensitive plant growing in Africa, South Asia and Madagascar's tropical region. It has an intriguing characteristic that is similar to that of the touch-me-not plant. This article describes the synonyms, biological source, phytoconstituents and various pharmacological activities of Biophytum sensitivum (L.) DC, which include Anti-inflammatory, Anti diabetic, Anti urolithiatic, Antibacterial, Immunomodulatory and anti tumor activity, Nephroprotective activity, Antifertility, Radioprotective, Hypocholesterolemic effect, Wound healing, Anti-fungal activity, Antihypertensive, Analgesic activity, Antipyretic activity, Chemoprotective activity, Anti-fungal activity ,Anti angiogenic activity, Anti-metastatic activity, Larvicidal activity and Diuretic activity.
Keywords:
Biophytum sensitivum, little tree plant, Daspushpum, Oxalidaceae
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References
1)Sakthivel KM, Guruvayoorappan C. Biophytum sensitivum: Ancient medicine, modern targets. Journal of advanced pharmaceutical technology & research. 2012 Apr;3(2):83.
2) Babas SY, Luka CD, Istifanus G, Mayel MH. DETERMINATION OF THE ANTIDIABETIC PROPERTY OF THE AQUEOUS EXTRACT OF BIOPHYTUM SENSITIVUM ON STREPTOZOTOCIN INDUCED DIABETIC RATS. GSJ. 2020 Aug;8(8).
3) George MA, Urumbil SK, Anilkumar M. Isolation, Identification and Characterisation of Endophytic Bacteria in Biophytum sensifivum (L.) DC. J. Pure Appl. Microbiol. 2020;14(1):647
4) Kala SC, Mallikarjuna K. A short review on callus studies of Biophytum sensitivum Linn. World Journal of Microbiology Research. 2015 Jan 23;4(4):985-91.
5) Bharati AC, Sahu AN. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC. Pharmacognosy reviews. 2012 Jan;6(11):68.
6) Chandavarkar SK, Desai SM. Diuretic activity of different extracts of Biophytum sensitivum (Linn.) DC. Ayu. 2015 Jul;36(3):356.
7) Mishra M, Bandyopadhyay D, Pramanik KC, Chatterjee TK. Antihyperglycemic activity of Biophytum sensitivum (L.) DC in alloxan diabetic rats. Oriental Pharmacy and Experimental Medicine. 2007;7(4):418-25.
8) Kala SC, Vijayalakshmi M, Khalivulla SI, Mallikarjuna K. Phytochemical and Antimicrobial Analysis of Callus Extracts of Biophytum sensitivum (Linn) DC. Microbiology Research Journal International. 2014 May 6:869-84.
9) Subramanian A, Kumar SS, Suja SK, Sudarshanand M, Chakraborty A. Antioxidant and free radical scavenging activity of annular and seasonal ayurvedic medicinal plants Elephantopus scaber L. and Biophytum sensitivum DC. Int. J. Pharm. Bio. Chem. Sci. 2014;1:06-17.
10) Pawar AT, Vyawahare NS. Protective effect of standardized extract of Biophytum sensitivum against calcium oxalate urolithiasis in rats. Bulletin of Faculty of Pharmacy, Cairo University. 2015 Dec 1;53(2):161-72.
11) Kumar PT, Kalita P, Burman TK, Chatterjee TK, Maity S. FORMULATION AND EVALUATION OF ANTIDIABETIC TABLET CONTAINING WHOLE PLANT EXTRACT OF BIOPHYTUM SENSITIVUM ON THE BASIS OF TOTAL FLAVONOID CONTENT. World Journal of Pharmaceutical Research. 2013 Apr 20;2(4):986-1007.
12) Sajith Kumar PN, Rajagopal PL, Arthi I, Anjana AK, Yamuna CV. AN UPDATED REVIEW ON VARIOUS PHARMACOLOGICAL ACTIVITY OF BIOPHYTUM SENSITIVUM
13) Zade D, Pathak S, Khobragade P, Wairagade S, Fadanvis P. Review of Viparit lajjalu (Biophytum sensitivum Linn.) and its Effect on Sperms. Int J Cur Res Rev| Vol. 2021 Apr;13(07):64.
14)Mathew George, Lincy Joesph and Umesh Kumar. 2016. Biophytum sensitivum Chemical Constituents and Medicinal Properties: A ReviewInt.J.Curr.Res.Aca.Rev. 4(7): 57-67
15) PK L, Sajith Kumar PN, Rajagopal PL, Arthi I, Anjana AK, Yamuna CV. AN UPDATED REVIEW ON VARIOUS PHARMACOLOGICAL ACTIVITY OF BIOPHYTUM SENSITIVUM.
16) Bharati AC, Sahu AN. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC. Pharmacognosy reviews. 2012 Jan;6(11):68.
17)Jachak SM, Bucar F, Kartnig T. Antiinflammatory activity of extracts of Biophytum sensitivum in carrageenin‐induced rat paw oedema. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 1999 Feb;13(1):73-4.
18) Ananda PK, Kumarappan CT, Christudas S, Kalaichelvan VK. Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine. 2012 Jan 1;2(1):31-5.
19)Pawar AT, Vyawahare NS. Anti-urolithiatic activity of standardized extract of Biophytum sensitivum against zinc disc implantation induced urolithiasis in rats. Journal of advanced pharmaceutical technology & research. 2015 Oct;6(4):176.
20)Natarajan D, Shivakumar MS, Srinivasan R. Antibacterial activity of leaf extracts of Biophytum sensitivum (L.) DC. Journal of pharmaceutical sciences and Research. 2010 Nov 1;2(11):717
21)Guruvayoorappan C, Afira AH, Kuttan G. Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo. Journal of basic and clinical physiology and pharmacology. 2006 Dec 1;17(4):255-68.
22) Guruvayoorappan C, Kuttan G. Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pacific Journal of cancer prevention. 2007 Jan 1;8(1):27.
23) Chandavarkar S, Desai M, Gautam G. Nephroprotective activity of different extracts of Biophytum sensitivum (Linn.) DC. Int J Herb Med. 2017;5(1):31-4.
24) Johnson DB, Dinesh Kumar C, Arunkanth KR, Giles D, Gopal M, Hubert VG. Antifertility activity of Biophytum sensitivum. Indian drugs. 2003;40(9):523-5.
25)Guruvayoorappan C, Kuttan G. Protective effect of Biophytum sensitivum (L.) DC on radiation-induced damage in mice. Immunopharmacology and immunotoxicology. 2008 Jan 1;30(4):815-35.
26) Puri D. Hypocholesterolemic effect of Biophytum sensitivum leaf water extract. Pharmaceutical biology. 2003 Jan 1;41(4):253-8.
27) Inngjerdingen KT, Coulibaly A, Diallo D, Michaelsen TE, Paulsen BS. A complement fixing polysaccharide from Biophytum p etersianum Klotzsch, a medicinal plant from Mali, west Africa. Biomacromolecules. 2006 Jan 9;7(1):48-53.
28) Titrikou S, Eklu-Gadegbeku K, Mouzou A, Aklikokou K, Gbeassor M. Calcium antagonistic activity of Biophytum petersianum on vascular smooth muscles of wistar rat. Iranian Journal of Pharmacology & Therapeutics. 2008 May 24;6(2):185-9.
29) Chatterjee TK, Mishra M, Pramanik K, Bandyopadhyay D. Evaluation of Anti-inflammatory, Antipyretic and Analgesic properties of Biophytum sensitivum (L.) DC. Indian Drugs. 2008 Feb 1;45(2):123-31.
30) Guruvayoorappan C, Kuttan G. Evaluation of the chemoprotective effect of Biophytum sensitivum (L.) DC extract against cyclophosphamide induced toxicity in Swiss albino mice. Drug metabolism and drug interactions. 2007 Jun 1;22(2-3):131-50.
31) Ida B, Seema D, Shital D, Riva S, Astrida R. Antimicrobial activity of ten common herbs, commonly known as Dashapushpam from Kerala, India. African Journal of microbiology research. 2010 Nov 18;4(22):2357-62.
32) Guruvayoorappan C, Kuttan G. Anti-angiogenic effect of Biophytum sensitivum is exerted through its cytokine modulation activity and inhibitory activity against VEGF mRNA expression, endothelial cell migration and capillary tube formation. Journal of experimental therapeutics & oncology. 2007 Jun 1;6(3).
33) Guruvayoorappan C, Kuttan G. Inhibition of tumor specific angiogenesis by amentoflavone. Biochemistry (Moscow). 2008 Feb;73(2):209-18.
34) Guruvayoorappan C, Kuttan G. Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice. Immunopharmacology and immunotoxicology. 2008 Jan 1;30(4):711-27.
35) Guruvayoorappan C, Kuttan G. Anti-metastatic effect of Biophytum sensitivumis exerted through its cytokine and immunomodulatory activity and its regulatory effect on the activation and nuclear translocation of transcription factors in B16F-10 melanoma cells. Journal of experimental therapeutics & oncology. 2008 Mar 1;7(1).
36) Shivakumar MS, Srinivasan R, Natarajan D. Bioefficacy of Biophytum sensitivum (L.) leaf extracts against dengue mosquito vector Aedes aegypti (L.). Res J Pharmaceut Biol Chem Sci. 2012;3(3):885-92.
37) Chandavarkar SK, Desai SM. Diuretic activity of different extracts of Biophytum sensitivum (Linn.) DC. Ayu. 2015 Jul;36(3):356.
38) Subramanian A, Kumar SS, Suja SK, Sudarshanand M, Chakraborty A. Antioxidant and free radical scavenging activity of annular and seasonal ayurvedic medicinal plants Elephantopus scaber L. and Biophytum sensitivum DC. Int. J. Pharm. Bio. Chem. Sci. 2014;1:06-17.
39) Xavier TF, Kannan M, Lija L, Auxillia A, Rose AK. Ethnobotanical study of Kani tribes in Thoduhills of Kerala, South India. Journal of Ethnopharmacology. 2014 Feb 27;152(1):78-90.
40) Poonam K, Singh GS. Ethnobotanical study of medicinal plants used by the Taungya community in Terai Arc Landscape, India. Journal of ethnopharmacology. 2009 May 4;123(1):167-76.
41) Singh A, Dubey NK. An ethnobotanical study of medicinal plants in Sonebhadra District of Uttar, Pradesh, India with reference to their infection by foliar fungi. Journal of Medicinal Plants Research. 2012 Apr 16;6(14):2727-46.
42) Sivasankari B, Anandharaj M, Gunasekaran P. An ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of Thoppampatti, Dindigul district, Tamilnadu, India. Journal of Ethnopharmacology. 2014 Apr 28;153(2):408-23.
43) Kuvar SD, Shinde RD. ETHNOBOTANICAL STUDIES ON KOKNI TRIBE OF MAHARASHTRA. Journal of Global Biosciences. 2019;8(3):6034-42.
44) Rajith NP, Ramachandran VS. Ethnomedicines of Kurichyas, Kannur district, Western Ghats, Kerala.
45) Kamble SY, Patil SR, Sawant PS, Sawant S, Pawar SG, Singh EA. Studies on plants used in traditional medicine by Bhilla tribe of Maharashtra.
46) Silja VP, Varma KS, Mohanan KV. Ethnomedicinal plant knowledge of the Mullu kuruma tribe of Wayanad district, Kerala.
2) Babas SY, Luka CD, Istifanus G, Mayel MH. DETERMINATION OF THE ANTIDIABETIC PROPERTY OF THE AQUEOUS EXTRACT OF BIOPHYTUM SENSITIVUM ON STREPTOZOTOCIN INDUCED DIABETIC RATS. GSJ. 2020 Aug;8(8).
3) George MA, Urumbil SK, Anilkumar M. Isolation, Identification and Characterisation of Endophytic Bacteria in Biophytum sensifivum (L.) DC. J. Pure Appl. Microbiol. 2020;14(1):647
4) Kala SC, Mallikarjuna K. A short review on callus studies of Biophytum sensitivum Linn. World Journal of Microbiology Research. 2015 Jan 23;4(4):985-91.
5) Bharati AC, Sahu AN. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC. Pharmacognosy reviews. 2012 Jan;6(11):68.
6) Chandavarkar SK, Desai SM. Diuretic activity of different extracts of Biophytum sensitivum (Linn.) DC. Ayu. 2015 Jul;36(3):356.
7) Mishra M, Bandyopadhyay D, Pramanik KC, Chatterjee TK. Antihyperglycemic activity of Biophytum sensitivum (L.) DC in alloxan diabetic rats. Oriental Pharmacy and Experimental Medicine. 2007;7(4):418-25.
8) Kala SC, Vijayalakshmi M, Khalivulla SI, Mallikarjuna K. Phytochemical and Antimicrobial Analysis of Callus Extracts of Biophytum sensitivum (Linn) DC. Microbiology Research Journal International. 2014 May 6:869-84.
9) Subramanian A, Kumar SS, Suja SK, Sudarshanand M, Chakraborty A. Antioxidant and free radical scavenging activity of annular and seasonal ayurvedic medicinal plants Elephantopus scaber L. and Biophytum sensitivum DC. Int. J. Pharm. Bio. Chem. Sci. 2014;1:06-17.
10) Pawar AT, Vyawahare NS. Protective effect of standardized extract of Biophytum sensitivum against calcium oxalate urolithiasis in rats. Bulletin of Faculty of Pharmacy, Cairo University. 2015 Dec 1;53(2):161-72.
11) Kumar PT, Kalita P, Burman TK, Chatterjee TK, Maity S. FORMULATION AND EVALUATION OF ANTIDIABETIC TABLET CONTAINING WHOLE PLANT EXTRACT OF BIOPHYTUM SENSITIVUM ON THE BASIS OF TOTAL FLAVONOID CONTENT. World Journal of Pharmaceutical Research. 2013 Apr 20;2(4):986-1007.
12) Sajith Kumar PN, Rajagopal PL, Arthi I, Anjana AK, Yamuna CV. AN UPDATED REVIEW ON VARIOUS PHARMACOLOGICAL ACTIVITY OF BIOPHYTUM SENSITIVUM
13) Zade D, Pathak S, Khobragade P, Wairagade S, Fadanvis P. Review of Viparit lajjalu (Biophytum sensitivum Linn.) and its Effect on Sperms. Int J Cur Res Rev| Vol. 2021 Apr;13(07):64.
14)Mathew George, Lincy Joesph and Umesh Kumar. 2016. Biophytum sensitivum Chemical Constituents and Medicinal Properties: A ReviewInt.J.Curr.Res.Aca.Rev. 4(7): 57-67
15) PK L, Sajith Kumar PN, Rajagopal PL, Arthi I, Anjana AK, Yamuna CV. AN UPDATED REVIEW ON VARIOUS PHARMACOLOGICAL ACTIVITY OF BIOPHYTUM SENSITIVUM.
16) Bharati AC, Sahu AN. Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC. Pharmacognosy reviews. 2012 Jan;6(11):68.
17)Jachak SM, Bucar F, Kartnig T. Antiinflammatory activity of extracts of Biophytum sensitivum in carrageenin‐induced rat paw oedema. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 1999 Feb;13(1):73-4.
18) Ananda PK, Kumarappan CT, Christudas S, Kalaichelvan VK. Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine. 2012 Jan 1;2(1):31-5.
19)Pawar AT, Vyawahare NS. Anti-urolithiatic activity of standardized extract of Biophytum sensitivum against zinc disc implantation induced urolithiasis in rats. Journal of advanced pharmaceutical technology & research. 2015 Oct;6(4):176.
20)Natarajan D, Shivakumar MS, Srinivasan R. Antibacterial activity of leaf extracts of Biophytum sensitivum (L.) DC. Journal of pharmaceutical sciences and Research. 2010 Nov 1;2(11):717
21)Guruvayoorappan C, Afira AH, Kuttan G. Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo. Journal of basic and clinical physiology and pharmacology. 2006 Dec 1;17(4):255-68.
22) Guruvayoorappan C, Kuttan G. Immunomodulatory and antitumor activity of Biophytum sensitivum extract. Asian Pacific Journal of cancer prevention. 2007 Jan 1;8(1):27.
23) Chandavarkar S, Desai M, Gautam G. Nephroprotective activity of different extracts of Biophytum sensitivum (Linn.) DC. Int J Herb Med. 2017;5(1):31-4.
24) Johnson DB, Dinesh Kumar C, Arunkanth KR, Giles D, Gopal M, Hubert VG. Antifertility activity of Biophytum sensitivum. Indian drugs. 2003;40(9):523-5.
25)Guruvayoorappan C, Kuttan G. Protective effect of Biophytum sensitivum (L.) DC on radiation-induced damage in mice. Immunopharmacology and immunotoxicology. 2008 Jan 1;30(4):815-35.
26) Puri D. Hypocholesterolemic effect of Biophytum sensitivum leaf water extract. Pharmaceutical biology. 2003 Jan 1;41(4):253-8.
27) Inngjerdingen KT, Coulibaly A, Diallo D, Michaelsen TE, Paulsen BS. A complement fixing polysaccharide from Biophytum p etersianum Klotzsch, a medicinal plant from Mali, west Africa. Biomacromolecules. 2006 Jan 9;7(1):48-53.
28) Titrikou S, Eklu-Gadegbeku K, Mouzou A, Aklikokou K, Gbeassor M. Calcium antagonistic activity of Biophytum petersianum on vascular smooth muscles of wistar rat. Iranian Journal of Pharmacology & Therapeutics. 2008 May 24;6(2):185-9.
29) Chatterjee TK, Mishra M, Pramanik K, Bandyopadhyay D. Evaluation of Anti-inflammatory, Antipyretic and Analgesic properties of Biophytum sensitivum (L.) DC. Indian Drugs. 2008 Feb 1;45(2):123-31.
30) Guruvayoorappan C, Kuttan G. Evaluation of the chemoprotective effect of Biophytum sensitivum (L.) DC extract against cyclophosphamide induced toxicity in Swiss albino mice. Drug metabolism and drug interactions. 2007 Jun 1;22(2-3):131-50.
31) Ida B, Seema D, Shital D, Riva S, Astrida R. Antimicrobial activity of ten common herbs, commonly known as Dashapushpam from Kerala, India. African Journal of microbiology research. 2010 Nov 18;4(22):2357-62.
32) Guruvayoorappan C, Kuttan G. Anti-angiogenic effect of Biophytum sensitivum is exerted through its cytokine modulation activity and inhibitory activity against VEGF mRNA expression, endothelial cell migration and capillary tube formation. Journal of experimental therapeutics & oncology. 2007 Jun 1;6(3).
33) Guruvayoorappan C, Kuttan G. Inhibition of tumor specific angiogenesis by amentoflavone. Biochemistry (Moscow). 2008 Feb;73(2):209-18.
34) Guruvayoorappan C, Kuttan G. Amentoflavone inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice. Immunopharmacology and immunotoxicology. 2008 Jan 1;30(4):711-27.
35) Guruvayoorappan C, Kuttan G. Anti-metastatic effect of Biophytum sensitivumis exerted through its cytokine and immunomodulatory activity and its regulatory effect on the activation and nuclear translocation of transcription factors in B16F-10 melanoma cells. Journal of experimental therapeutics & oncology. 2008 Mar 1;7(1).
36) Shivakumar MS, Srinivasan R, Natarajan D. Bioefficacy of Biophytum sensitivum (L.) leaf extracts against dengue mosquito vector Aedes aegypti (L.). Res J Pharmaceut Biol Chem Sci. 2012;3(3):885-92.
37) Chandavarkar SK, Desai SM. Diuretic activity of different extracts of Biophytum sensitivum (Linn.) DC. Ayu. 2015 Jul;36(3):356.
38) Subramanian A, Kumar SS, Suja SK, Sudarshanand M, Chakraborty A. Antioxidant and free radical scavenging activity of annular and seasonal ayurvedic medicinal plants Elephantopus scaber L. and Biophytum sensitivum DC. Int. J. Pharm. Bio. Chem. Sci. 2014;1:06-17.
39) Xavier TF, Kannan M, Lija L, Auxillia A, Rose AK. Ethnobotanical study of Kani tribes in Thoduhills of Kerala, South India. Journal of Ethnopharmacology. 2014 Feb 27;152(1):78-90.
40) Poonam K, Singh GS. Ethnobotanical study of medicinal plants used by the Taungya community in Terai Arc Landscape, India. Journal of ethnopharmacology. 2009 May 4;123(1):167-76.
41) Singh A, Dubey NK. An ethnobotanical study of medicinal plants in Sonebhadra District of Uttar, Pradesh, India with reference to their infection by foliar fungi. Journal of Medicinal Plants Research. 2012 Apr 16;6(14):2727-46.
42) Sivasankari B, Anandharaj M, Gunasekaran P. An ethnobotanical study of indigenous knowledge on medicinal plants used by the village peoples of Thoppampatti, Dindigul district, Tamilnadu, India. Journal of Ethnopharmacology. 2014 Apr 28;153(2):408-23.
43) Kuvar SD, Shinde RD. ETHNOBOTANICAL STUDIES ON KOKNI TRIBE OF MAHARASHTRA. Journal of Global Biosciences. 2019;8(3):6034-42.
44) Rajith NP, Ramachandran VS. Ethnomedicines of Kurichyas, Kannur district, Western Ghats, Kerala.
45) Kamble SY, Patil SR, Sawant PS, Sawant S, Pawar SG, Singh EA. Studies on plants used in traditional medicine by Bhilla tribe of Maharashtra.
46) Silja VP, Varma KS, Mohanan KV. Ethnomedicinal plant knowledge of the Mullu kuruma tribe of Wayanad district, Kerala.
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22/05/2022
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D, R., B. D. R, R. K. Mani, Gurusidda, and S. G. V. “A Current Study on Pharmacology and Phytochemistry of Biophytum Sensitivum”. International Journal of Pharmacognosy and Chemistry, Vol. 3, no. 2, May 2022, pp. 64-71, doi:10.46796/ijpc.v3i2.319.
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