Controlled release miglitol microspheres formulation development and evaluation
Abstract
The research explain about Miglitol site in the body and also to achieve and maintain the desired ISD concentration, having 2 hour half-life and low bioavilability. The paper give information about nine formulations formulated by using HPMC K15M, Ethyl cellulose and karaya gum in different proportions. The FTIR Spectra revealed that, there was no interaction between polymers and Miglitol. As the polymer ratio was increased, the mean particle size of Miglitol microspheres was also increased. From the results it can be inferred that there was a proper distribution of Miglitol in the microspheres and the deviation was within the acceptable limits. On the basis of release data and graphical analysis formulation F6 containing HPMC K15M showed a good controlled release profile up to 12hrs with maximum entrapment efficiency because of high polymer concentration and follows zero order kinetics with super case II transport mechanism.
Keywords:
Miglitol, Ethyl Cellulose, HPMC K15M, FTIR and Karaya gum
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References
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3. https://pubchem.ncbi.nlm.nih.gov/compound/441314
4. Karuppusamy, C. & Palanivel, Venkatesan. (2017). Preformulation parameters characterization to de-sign, development and formulation of miglitol loaded nanoparticles. 9. 326-331.
5. Kavita K, RajeV, et al. 2010. Albumin Micro-spheres: AUnique system as drug delivery car-riers for non-steroidal anti-inflammatory drugs. 5(2):1219.
6. Khar R.K, Vyas, S.P. 2002. Targeted and Con-trolledDrug Delivery- Novel Carrier Systems., 1st edition,CBS Publications and Distributors, New Delhi ;417-418.
7. Barhate SD. Rupnar YS,. Sonvane RM, Pawar KR, Rahane RD formulation and evaluation of floating microspheres of ketorolac trometamol. IJPRD 2009;1(9):1-8.
8. G. Rath, E.S. Johal, A.K. Goyal. Development of serratiopeptidase and metronidazole based algi-nate microspheres for wound healing. Artif Cells Blood Substit Immobil Biotechnol, 39 (2011), pp. 44-50
9. A.H. El-Kamel, D.H. Al-Shora, Y.M. El-Sayed. Formulation and pharmacodynamic evaluation of captopril sustained release microparticles. J Mi-croencapsul, 23 (2006), pp. 389-404.
10. Dortune, B.; Ozer, L.and Vyanik, N.(1998) “Devel-opment and invitro Evaluation of buccoadhesive pindodlo tablet formulation.” Drug Dev.Ind.pharm., 24(3):281-288. 30.
11. Guo, J.H. (1994) “Bioadhesive polymer buccal patches for buprenorphine controlled delivery: formulation in vitro adhesive and release proper-ties”. Drug Dev.Ind.pharm., 20(3):315- 325.
12. Nagai, T.; Machida, Y.; Suzuki Y.and Ikura, H. (1980) “Method & preparation for administration to the mucosa & preparation for administration to the mucosa of the oral or nasal cavity” US patent NO.4226848.
13. Chein, Y.W.and Novir, M. (1996) “Mucosal adhe-sive device for long acting delivery of pharmaceu-tical combinations in oral cavity”. US patent NO.5578315.
14. Fabregas, J.L.and Garcia, N. (1995) “Invitro studies on buccoadhesive tablet formulations of hydro cortisone hemisuccinate”. Drug Dev.Ind.pharm., 21(14): 1689-1696.
15. Rathbone, M.J.; Purve, R.: Ghazati, F.A.and HO, P.C. (1996) “In vivo techniques for studying the oral mucosa absorption characteristics of drugs in animals and humans.” In Rathbone, M.J. (ed.), oral mucosal delivery systems, Marcel Dekker Inc.Newyork., 121-156.
16. Lu, M.F.and Hui, H.W. (1996) “Delivery of rennin inhibitors through mouth mucosa”. Drug Dev.Ind.pharm., 22 (11); 1167-1171.
17. Higuchi T. Mechanism of sustained action medication. Theroetical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963; 51: 1145-9.
18. Peppas NA. Analysis of Fickian and non-fickian drug release from polymer. Pharm Acta Helv 1985; 60: 110-11.
19. Marabathuni VJ, Dinesh P, Ravikumar R, Yamini P, Kiran PS, Hussain SP, Rao CM. Chitosan based sus-tained release mucoadhesive buccal patches con-taining amlodipine besylate (AMB). Asian Journal of Research in Pharmaceutical Science. 2017;7(2):97-104.
20. Marabathuni VJ, Bhavani M, Lavanya M, Padmaja K, Madhavi N, Babu P, Rao CM. Formulation and evaluation of mouth dissolving Tablets of carbam-azepine. Asian Journal of Pharmacy and Technolo-gy. 2017;7(3):137-43.
21. Babu AK, Teja NB, Ramakrishna B, Kumar BB, Reddy GV. Formulation and evaluation of double walled microspheres loaded with pantoprazole. METHODS. 2011;15:28.
22. Babu AK, Reddy VR, Reddy N, Vidyasagar J. Eval-uating the post compression parameter of ibu-profen by using super disintegrants. An Int J Adv Pharm Sci. 2010;1(2):247-53.
23. Aruna MS, Babu AK, Thadanki M, Gupta ME. Solid dispersions–an approach to enhance the dissolu-tion rate of Irbesartan. IJRPC. 2011;1(4):780-7.
24. Babu K, Ramana MV. Development and in vivo evaluation of gastro retentive floating tablets of antipsychotic drug risperidone. Int J Pharm Pharm Sci. 2016;11:43-52.
25. Babu AK, Ramana MV. In Vitro and In Vivo Eval-uation of Quetiapine Fumarate controlled gas-troretentive floating drug delivery system.
Published
08/01/2022
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How to Cite
K, P. K., V. J. P. Marabathuni, and N. Narapusetty. “Controlled Release Miglitol Microspheres Formulation Development and Evaluation ”. International Journal of Pharmacognosy and Chemistry, Vol. 3, no. 1, Jan. 2022, pp. 01-09, doi:10.46796/ijpc.v3i1.260.
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