C. Phyllacanthus antioxidant & protective activity in albino wister rats

Prachetha  Kolli; Sudhakar  Kancharla; Dr.K.Venkata  Gopaiah

doi:10.46796/ijpc.vi.138

Prachetha Kolli Scientist, Microgen Health Inc, 14225, Sullyfield Cir Suite E, Chantilly, VA, USA-2015.
Sudhakar Kancharla Director Clinical Laboratory, Devansh Lab Werks, 234, Aquarius Drive, Homewood, Alabama, USA-3520.
Dr.K.Venkata Gopaiah Associate Professor,St. Mary’s College of Pharmacy,Chebrolu, Guntur-A.P-522 212-India

DOI https://doi.org/10.46796/ijpc.vi.138

Abstract

In this present study I have selected a plant, which has shown good hepato protective as well as antioxidant properties. Undoubtedly , the plant kingdom still hold many species of plant containing substances of medicinal value, which have yet to be discovered ; large numbers of plants are constantly being screened for their possible pharmacological value particularly for their hepato protective properties. A large number of plants and formulations have been claimed to have hepato protective activity. Nearly 160 phyto constituents from 101 plants belonging to 55 families have been claimed to possess liver protecting activity. In India, more than 87 plants are used in 33 patented and proprietary multi-ingredient plant formulations.The ability of EECP to enhance the levels of antioxidants along with its anti lipid per oxidative activity suggests that this compound might be potentially useful in counteracting free-radical-mediated tissue damage caused by hepato toxicity. Studies on the antioxidative potency of various flavonoids have confirmed the importance of the distribution and quantity of the hydroxyl groups. In general, the antioxidative properties of polyphenols depend on hydroxylation of ring B. The present results corroborate the protective action of EECP in D- galactosamine intoxication of rats, particularly noticeable with the high dose used by us (400 mg/kg body weight). Supplementation with this flavonoid ameliorated the hepato protective and antioxidant activity in D-galactosamine-induced hepatitis in rats.

Keywords: Hepatoprotective, Antioxidant activity

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References

Vijayalakshmi, R., Ranganathan,R. Ethnobotanical Studies on Some Traditional Medicinal Plants in Cuddalore District. Drug Invention Today.2011, 3(7): 160- 164.

Mohamed, S.T.S., Madhusudhana C.C., Ramkanth,S., Rajan, V.S.T., Mahesh,K.K., Gauthaman, K. Hepatoprotective Herbs – A Review.Int. J. Res. Pharm. Sci.,2010. 1(1). 1-5http://www.phytochemicals.info/free-radicals.php

Harmon,D., Gerontol,J., 1956,11:298-300

Kappus,H.Arch.Toxicology.1987,60:144

Harsh, M.Cellinjuary and cellular adaptation. Text book of pathology .,2005,5: 38-40.

Abheri, D. S., Anisur, R. M., and Ghosh,A.K. Free Radicals and Their Role in Different Clinical Conditions: An Overview. International Journal of Pharma Sciences and Research,.2010,1(3): 185-192.

http://www.uv.es/frag/oxidative_stress.htm

Marian,V.,Dieter, L., Jan, M.,Mark, T.D., Cronin. Free radicals and antioxidants in normal physiological functions and human disease.The International Journal of Biochemistry & Cell Biology.,2007,39: 44–84.

Dipak,D.,Ranjith, K.,Banerjee.Reactive oxygen species :Oxydative Damage and Pathogenesis.Current science.1999,3(5):77.

Hellsten,Y.The role of Xanthine oxidase in exercise.Elesevier Science publisher,1994:221-234.

Edmonds,S.E.,Blake,D.R.Hypoxia,oxidative stress and exercise in rheumatoid arthritis.Elesevier science publishers B.V.,Amstradam,1994:389-422.

Lilus,E.M.,Manila,P.Photon emission of phagocytes in relation to sterss and disease.Experientia.,1992,48:1082-1091.

Otta,D.M.E.,Lindstrom.Seppa,p.,Sen,C.K.Cytochrome P450 dependent enzyme and oxidant-mediated responses in rainbow trout exposed to condaminated sediments. Ecotoxic Environ Safe., 1994,27:265-280.

Karuzine ,Archkov,A.L.The oxidative inactivation of cytochrome P450 in monooxigenasereaction.Free Rad Biol Med.,1994,16:74-97.

Beckman,J.S.,Crow,J.P.Pathological implication of nitric oxide ,superoxide and peroxynitrite formation.BiochemSoc Trans.,1993,21:330-334.

Hogg,N.,Darley.,UsmarV.M.,Wilson ,M.T.,Moncada,S.The oxidation of alpha

tocopherol in human low density lipoprotien by the simultanious generation of super oxide and nitric oxide.FEBS Lett.1993,326:199-203.

Jenkins,R.R.,Halliwell,B.Metal binding agents possible role in exercise. In exercise and oxygen toxicity. Elsevier science publishers., Amstradam,B.V.,1994:59-76.

Buettner,G.R.Ascorbate autoxidation in the presence of is iron and copper chelates.

Free Radical Res Commun.,1986,1:349-353.

Sies,H.Biochemistry of the peroxysomes in the liver cells. AngewChemInt Ed Engl.1974,13:706-718.

Kukreja,R.C.,Kontos,H.A.,Hess,M.L.,Ellis,E.F. PGH synthase and lipoxigenase generate superoxide in the presence of NADH of NADPH.Circ Res,1986,59:612- 619.

Arduini,A.,Eddy,L.,Hochestein,P. Detection of ferryl myoglobin in the isolated ischemic rat heart.Free Red Biol Med.,1990,9:511-513.

Uday, B., Dipak, D.,Ranajit, K. B. Reactive oxygen species: Oxidative damage And pathogenesis.CURRENT SCIENCE,1999,77( 5):658-666.

Carwin,H.The rational design,mechanistic study and therapeutic application of chemical compounds.Comprehensive medicinal chemistry,1990,2(3):734-738.

Gutteridge,J.M.C.,Halliwell,B.Oxygen and suphur radicals in chemistry and Med.1986,22:47.

MARK ,P,.Antioxidants.CLINICAL NUTRITION INSIGHTS.,1998,1:1-4.

Ohno,H.S.,Fujii,K.,Yamashita,J.H.,Kizaki,T.,Oh-ishi,S.,Tanaguchi,N.Superoxide dismutases in exercise and disease.Elesivier science publishers,1994.,127-162.

Sulekha, M., Satish, Y.,Sunita, Y.,Rajesh,K.N.Antioxidants: A Review. Journal of Chemical and Pharmaceutical Research,2009., 1 (1):102-104.

Shalini,S.International Journal of Physiotherapy.2012.2(1):7-15.

Hercılia ,M. H.,Jofre ,J.S. F., Rui ,C.,Irineu, T. V., Bonfim, A.S., Junior.International Journal of Physiotherapy.2006.,3(2):144-153.

Halliwel,B.In oxygen radicles and disease process.Hardwardaccademic publisher.,Netherlands,1997:1-14.

Eqbal M.A.D.,Aminah ,A.,Halimah,A.S. Natural Antioxidants, Lipid Profile, Lipid Peroxidation, Antioxidant Enzymes of Different Vegetable Oils., Advance Journal of Food Science and Technology., 2011.,3(4): 308-316.

Ralf, D. Metabolism and functions of glutathione inbrain.,Progress in Neurobiology.,2000.,62 :649-671.

Chih ,c.L., Wu-hsiung, H.,Augusta, A., Leslie, M. K., Ted ,H. C. Expression of glutathione peroxidase and catalase in copper-deficient rat liver and heart., Nutritional Biochemistry.,1995.,6:256-262.

Anna P., Giorgio ,F., Enrico, B., Fiorella ,P. Analysis of glutathione: implication in redox and detoxification. Clinica ChimicaActa 2003,333:19–39.

Noeleen, B. L., Brendan O'C., Ciarán, Ó.'Fi.,Mary.,J .O The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions.BMCEvol Biol. 2008.,8: 101.

Dominique ,P., Pascal, C., Fernand, L., Catherine. R. Antioxidant activity of some ascorbic and cinnamic acids derivatives. IL Farmaco.,1998.,53 :85-88

Estany S., J.R. Palacio, J.R.,Barnadas, R.,Sabes, miborra,A., Mart´ınez ,P. Antioxidant activity of N-acetylcysteine, flavonoids and -tocopherol on endometrial cells in culture.Journal of Reproductive Immunology,2007.,75: 1–10.

Lawrence,G.,Plaskett,B,A., Antioxidants our indispensible protection. Biomedical information services.,2003:1-11.

Pascoe,G.A.,Redd,D.J.Cell calcium,vitaminE,andthol redox system in cytotoxicity.,

Free radical Bio Med.1989,6:209-224.

Sen,C.K,Agarwal,Y.P.,Hanninen,O.Changes in intracellular calcium and membrane disentegration following exposure of myogenic cells to oxidative stress.XXXII Congress of the international union of physiological Sciences.1993.,214:345-356.

Orolv,S.N.,Sen,C.K.,Kolosova,I.A.Evidence for the involvement of G protien in the modulation of sodium and calcium cluxes in myogenic L6 and arotic smooth musclecells.BiochemBiophys Res Commun.1993,191:802-810.