An observational study on the proves of the risk in the combination of Diclofenac and Ibuprofen

  • Dr.Sd. Abdul Jabbar Basha Department of Pharmacology, Associate Professor, ASN Pharmacy College, Tenali, Andhrapradesh, India
  • Naga lakshmi Department of Pharmacy Practice, Pharm D IVth Year, ASN Pharmacy College, Tenali, Andhrapradesh, India.
  • Dr.K.Venkata Ramana Department of Pharmacy, Professor and Principal, ASN Pharmacy College, Tenali, Andhrapradesh, India.

Abstract

NSAID'S Drugs are presently highly recommended and excessive OTC drugs that are available in the market and the combinations have been used largely in the NSAID's. So, there is an increasing risk of DI that may give adverse effects. Among these, the recent study has concluded that the combination of diclofenac and ibuprofen has a high risk of cardiac arrest. Both drugs are having potent action of anti-inflammatory action but if they are used in large doses it may result from cardiac arrest. This article gives you the observational study of the Proves for the developing risk in this combination.Unless new studies become available, NSAIDs should be used one at a time, with supplementary analgesics added on a PRN basis.

Keywords: Diclofenac, Ibuprofen, Cardiac arrest

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References

Sondergaard K, Weeke P, Wassenberg M et al. Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case-time-control study. Eur Heart J CardiovascPharmacother 2017;356:100-107. doi: 10.1093/ehjcvp/pvw041.

The pharmaceutical journal...Clinical Pharmacist, April 2017, Vol 9, No 4, online | DOI: 10.1211/CP.2017.20202466.

NPS medicine wise publication 9thOct 2017.
Published
23/02/2021
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How to Cite
Basha, D. A. J., N. lakshmi, and D. Ramana. “An Observational Study on the Proves of the Risk in the Combination of Diclofenac and Ibuprofen”. International Journal of Pharmacognosy and Chemistry, Vol. 2, no. 1, Feb. 2021, pp. 12-13, doi:10.46796/ijpc.vi.132.
Section
Research Article