WERNICKES  KORSAKOFF SYNDROME

Syam Prashanth Pedada Syam Prashanth Pedada; Jyotsna Allamsetty Jyotsna Allamsetty; Ujwala Mukthipudi Ujwala Mukthipudi

Syam Prashanth Pedada Department of Pharmacy Practice, Avanthi Institute of Pharmaceutical Sciences, Cherukupally (Vil), Bhogapuram (M), Vizianagaram (Dist), A.P-531162.
Jyotsna Allamsetty Department of Pharmacy Practice, Avanthi Institute of Pharmaceutical Sciences, Cherukupally (Vil), Bhogapuram (M), Vizianagaram (Dist), A.P-531162.
Ujwala Mukthipudi Department of Pharmacy Practice, Avanthi Institute of Pharmaceutical Sciences, Cherukupally (Vil), Bhogapuram (M), Vizianagaram (Dist), A.P-531162.

Abstract

Wernickes korsakoff syndrome (WKS) is a combined disorder of Wernicke's encephalopathy and korsakoff psychosis which is a neurological disorder. Wernicke enchplaophaty and korsakoff psychosis are the acute and the chronic phase respectively, wernickes korsakoff syndrome is mostly observed in chronic alcoholism and rarely with non-alcoholics. It includes symptoms of diplopia,ophthalmoplegis, ataxia, retrograde and anterograde amnesia. It is easily diagnosed by a dietary deficiency, ocular abnormalities, cerebellar dysfunction, memory impairment.WKS also include gliosis and microhemorrhages in periaqueductal and paraventricular grey matter, atrophy in the mamillary bodies and thalamus, volume deficits in the hippocampus, cerebellar hemispheres, pons, and anterior superior vermis. In the early stages of the Wernicke's korsakoff can be preventable to the chronic stage irreversible stage of korsakoff psychosis by treating it with thiamine for few days and the improvement of the symptoms is observed after few weeks.

Keywords: Wernickes korsakoff syndrome, encephalopathy, cerebllar dysfunction, korsakoff psychosis

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