Review on: mucoadhesive medication delivery methods
Abstract
Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic activity. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review covers the areas of mechanisms and theories of mucoadhesion, factors influencing the mucoadhesive materials, mucoadhesive polymers, and also various mucoadhesive dosage forms.
Keywords:
Mucoadhesive, drug delivery systems, Mucoadhesive dosage forms and mucoadhesive polymers
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References
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12. Tangri P., Madhav N.V.S., Oral Mucoadhesive Drug Delivery System-A Review, Int. J. Of Biopharm. 2011; 2(1):36-46.
13. Boini, K.M., singh, A. and Koka, S.S., 2021. Gut Microbial Metabolite Trimethylamine N-oxide Enhances Endoplasmic Reticular Stress and Promotes Endothelial Dysfunction. Circulation, 144(Suppl_1), pp.A14071-A14071Smart JD, Nicholls TJ, Green KL, Rogers DJ, Cook JD. Lectins in Drug Delivery: a study of the acute local irritancy of the lectins from Solanum tuberosum and helix pomatia. Eur J Pharm Sci. 1999; 9:93–8.
14. Shiv Chandra Singh, A., Yu, A., Chang, B., Li, H., Rosenzweig, A. and Roh, J.D., 2021. Exercise Training Attenuates Activin Type II Receptor Signaling in the Aged Heart. Circulation, 144(Suppl_1), pp.A14259-A14259.
15. Nicholls TJ, Green KL, Rogers DJ, Cook JD, Wolowacz S, Smart JD. Lectins in ocular drug delivery.An investigation of lectin binding sites on the corneal and conjunctival surfaces. Int J Pharm. 1996; 138:175–83.
16. Hornof M, Weyenberg W, Ludwig A, Bernkop- Schnurch A. A mucoadhesive ophthalmic insert based on thiolated poly (acrylic) acid: Development and in vivo evaluation in human volunteers. J Control Release. 2003; 89:419–28.
17. Singh, A., Kumar, A. and Kalaiselvi, P., 2018. Aegeline, targets LOX1, the receptor for oxidized LDL to mitigate hypercholesterolemia: a new perspective in its anti-atherosclerotic action. Free Radical Biology and Medicine, 128, p.S41.
18. MATHIOWITZ, E.; CHICKERING, D. E.; LEHR, C M. (Eds.). Bioadhesive drug delivery systems: fundamentals, novel approaches, and development. Drugs and the Pharmaceutical Sciences. New York: Marcel Dekker, 1999. 696.
2. Ahuja A, Khar RK, Ali J. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm 1997; 23:489-515.
3. WOODLEY, J. Bioadhesion, new possibilities for drug dministration? Clin. Pharmacokinet., 2001;.40;(2):77-84.
4. HÄGERSTRÖM, H.; EDSMAN, K.; STRØMME, M. Low Frequency Dielectric Spectroscopy as a Tool for Studying the Compatibility between Pharmaceutical Gels and Mucus Tissue. J. Pharm. Sci., 2003; 92(9):1869-1881.
5. ANDREWS, G. P.; JONES, D. S. Rheological characterization of bioadhesive binary polymeric systems designed as platforms for drug delivery implants. Biomacromol, 2006; 7:899-906.
6. SMART, J. D. The basics and underlying mechanisms of mucoadhesion. Adv.Drug Del. Rev.2005; 57(11):1556- 1568.
7. Singh, A., Srinivasan, A.K., Chakrapani, L.N. and Kalaiselvi, P., 2019. LOX-1, the common therapeutic target in hypercholesterolemia: a new perspective of antiatherosclerotic action of aegeline. Oxidative medicine and cellular longevity, 2019.
8. EVANGELISTA, R. C. Sistemas de liberação controlada de fármacos. Araraquara, 2006. 345 f. [Tese de Livre Docência em Farmacotécnica. Faculdade de Ciências Farmacêuticas. Universidade Estadual Paulista "Júlio de Mesquita Filho"]
9. Kinloch AJ. The science of adhesion. J Mater Sci 1980; 15:2141-66. 9. Jiménez-Castellanos MR, Zia H, Rhodes CT. Mucoadhe-sive drug delivery systems. Drug Dev Ind Pharm 1993; 19:143-94
10. Jimenez-Castellanos MR, Zia H, Rhodes CT. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm. 1993; 19:143–94.
11. Roh, J., Hill, J.A., Singh, A.,Valero-Muñoz, M. and Sam, F., 2022. Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models. Circulation Research, 130(12), pp.1906-1925.
12. Tangri P., Madhav N.V.S., Oral Mucoadhesive Drug Delivery System-A Review, Int. J. Of Biopharm. 2011; 2(1):36-46.
13. Boini, K.M., singh, A. and Koka, S.S., 2021. Gut Microbial Metabolite Trimethylamine N-oxide Enhances Endoplasmic Reticular Stress and Promotes Endothelial Dysfunction. Circulation, 144(Suppl_1), pp.A14071-A14071Smart JD, Nicholls TJ, Green KL, Rogers DJ, Cook JD. Lectins in Drug Delivery: a study of the acute local irritancy of the lectins from Solanum tuberosum and helix pomatia. Eur J Pharm Sci. 1999; 9:93–8.
14. Shiv Chandra Singh, A., Yu, A., Chang, B., Li, H., Rosenzweig, A. and Roh, J.D., 2021. Exercise Training Attenuates Activin Type II Receptor Signaling in the Aged Heart. Circulation, 144(Suppl_1), pp.A14259-A14259.
15. Nicholls TJ, Green KL, Rogers DJ, Cook JD, Wolowacz S, Smart JD. Lectins in ocular drug delivery.An investigation of lectin binding sites on the corneal and conjunctival surfaces. Int J Pharm. 1996; 138:175–83.
16. Hornof M, Weyenberg W, Ludwig A, Bernkop- Schnurch A. A mucoadhesive ophthalmic insert based on thiolated poly (acrylic) acid: Development and in vivo evaluation in human volunteers. J Control Release. 2003; 89:419–28.
17. Singh, A., Kumar, A. and Kalaiselvi, P., 2018. Aegeline, targets LOX1, the receptor for oxidized LDL to mitigate hypercholesterolemia: a new perspective in its anti-atherosclerotic action. Free Radical Biology and Medicine, 128, p.S41.
18. MATHIOWITZ, E.; CHICKERING, D. E.; LEHR, C M. (Eds.). Bioadhesive drug delivery systems: fundamentals, novel approaches, and development. Drugs and the Pharmaceutical Sciences. New York: Marcel Dekker, 1999. 696.
Published
31/12/2022
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How to Cite
B, G. K., H. B, P. Ch, K. P, and S. K. K. “Review On: Mucoadhesive Medication Delivery Methods”. International Journal of Health Care and Biological Sciences, Vol. 3, no. 4, Dec. 2022, pp. 109-14, doi:10.46795/ijhcbs.v3i4.403.
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