https://saapjournals.org/index.php/ijhcbs <p>International Journal of Health Care and Biological Sciences (IJHCBS) is an international online open access, peer-reviewed, quarterly journal Publish Health as well as Life sciences field on the basis of its originality, and serve as a means for scientific information exchange in the international Health Care and Biological science with a strong emphasis on originality and scientific quality. IJHCBS aims to publish quarterly and accepts for publishing original and research articles, review articles, case studies, and reports short communication, meta-analysis.</p> International Journal of Health Care and Biological Sciences en-US International Journal of Health Care and Biological Sciences 2582-7499 https://saapjournals.org/index.php/ijhcbs/article/view/791 <p>A significant number of women of reproductive age struggle with PCOS, a complicated endocrine illness that frequently results in hormonal imbalance, irregular menstruation, and infertility. Systemic drug delivery is a common component of conventional treatment procedures, which may lead to systemic adverse effects and less than ideal therapeutic results. The purpose of this project is to create and assess an intravaginal drug delivery device as a targeted, sustained-release treatment method for PCOS symptoms. Metformin and clomiphene citrate, two medications frequently used to treat PCOS, were put into a mucoadhesive intravaginal gel that was created utilizing biocompatible polymers. PH compatibility, viscosity, drug release profile, mucoadhesive strength, and in vitro cytotoxicity were assessed for the formulation.The results showed excellent mucoadhesive qualities, appropriate pH and viscosity for vaginal administration, and sustained drug release over a 24-hour period. With the promise for improved therapeutic efficacy and decreased systemic exposure, the intravaginal method offered targeted medication delivery. With the goal of enhancing patient compliance and therapeutic results, this administration method presents a viable substitute for oral medication for PCOS.</p> Lakshmi Savithri S Copyright (c) 2026 https://creativecommons.org/licenses/by-nc/4.0 2026-01-20 2026-01-20 1 3 10.46795/ijhcbs.v7i1.791