A pharmacological approaches on moringa oleifera plant- a brief review
Abstract
In the last few decades use of traditional drugs has led to the popularization of herbal drugs because of their lesser side effects. This has led to the exploitation of the natural origin of many traditional plants for their pharmacological activities. Moringa oleifera one such traditional plant contains flavonoids, rhamnose, glucosinolate, isocytosinate, phenolic acids, carotenoids, tocopherols, vitamins and polyunsaturated fatty acids which shows anti-microbial, anti-fungal, hepatoprotective, anti-cancer, anti-diarrheal, anti-inflammatory, immunomodulatory and other pharmacological activities. The present review is to highlight the phytoconstituents, pharmacological effects and uses of Moringa oleifera over various diseases.
Keywords:
Moringa oleifera, hepatoprotective activity, immunomodulatory, anti-inflammatory, phytochemistry
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References
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18. Uppugalla S, Srinivasan P. Polyaniline nanofibers and porous Ni [OH] 2 sheets coated carbon fabric for high performance super capacitor. Journal of Applied Polymer Science. 2019 Nov 5;136(41):48042.
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21. Sreelatha S, Padma PR. Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity. Plant foods for human nutrition. 2009 Dec;64(4):303-11.
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25. Nandave M, Ojha SK, Joshi S, Kumari S, Arya DS. Moringa oleifera leaf extract prevents isoproterenol-induced myocardial damage in rats: evidence for an antioxidant, antiperoxidative, and cardioprotective intervention. Journal of medicinal food. 2009 Feb 1;12(1):47-55.
26. Muangnoi C, Chingsuwanrote P, Praengamthanachoti P, Svasti S, Tuntipopipat S. Moringa oleifera pod inhibits inflammatory mediator production by lipopolysaccharide-stimulated RAW 264.7 murine macrophage cell lines. Inflammation. 2012 Apr;35(2):445-55.
27. Uppugalla S, Boddula R, Srinivasan P. Methyl triphenylphosphonium permanganate as a novel oxidant for aniline to polyaniline-manganese (II, IV) oxide: material for high performance pseudocapacitor. Journal of Solid State Electrochemistry. 2018 Feb;22(2):407-15.
28. Lipipun V, Kurokawa M, Suttisri R, Taweechotipatr P, Pramyothin P, Hattori M, Shiraki K. Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral research. 2003 Nov 1;60(3):175-80.
29. Efstratiadis G, Divani M, Katsioulis E, Vergoulas G. Renal fibrosis. Hippokratia. 2009 Oct;13(4):224.
30. Kumar PS, Mishra D, Ghosh G, Panda CS. Medicinal uses and pharmacological properties of Moringa oleifera. International Journal of Phytomedicine. 2010 Jul 1;2(3).
31. Fakurazi S, Hairuszah I, Nanthini U. Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food and chemical toxicology. 2008 Aug 1;46(8):2611-5.
32. Gilani AH, Aftab K, Suria A, Siddiqui S, Salem R, Siddiqui BS, Faizi S. Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phytotherapy research. 1994 Mar; 8(2):87-91.
33. Nanjappaiah HM, Shivakumar H. Prophylactic and curative effects of Moringa oleifera Lam. pods in CCl4 damaged rat liver. Indian J Nat Prod Resours. 2012;3:541–6
34. Pari L, Kumar NA. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. Journal of Medicinal Food. 2002 Sep 1;5(3):171-7.
35. Suzana D, Suyatna FD, Andrajati R, Sari SP, Mun’im A. Effect of Moringa oleifera leaves extract against hematology and blood biochemical value of patients with iron deficiency anemia. Journal of Young Pharmacists. 2017;9(1s):S79.
36. Goyal BR, Goyal RK, Mehta AA. Investigation into the mechanism of anti-asthmatic action of Moringa oleifera. Journal of dietary supplements. 2009 Nov 13;6(4):313-27.
37. Mahajan SG, Mehta AA. Effect of Moringa oleifera Lam. seed extract on ovalbumin-induced airway inflammation in guinea pigs. Inhalation toxicology. 2008 Jan 1;20(10):897-909.
2. Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: a food plant with multiple medicinal uses. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007 Jan; 21(1):17-25.
3. Rathnayake AR, Navaratne SB, Uthpala TG. Moringa olifera plant and the nutritional and medicinal properties of Moringa olifera leaves.
4. Mahmood KT, Mugal T, Haq IU. Moringa oleifera: a natural gift-A review. Journal of Pharmaceutical Sciences and Research. 2010 Nov 1;2(11):775.
5. Pandey A, Pradheep K, Gupta R, Nayar ER, Bhandari DC. ‘Drumstick tree’ (Moringa oleifera Lam.): a multipurpose potential species in India. Genetic Resources and Crop Evolution. 2011 Mar; 58(3):453-60.
6. Razis AA, Ibrahim MD, Kntayya SB. Health benefits of Moringa oleifera. Asian Pac J Cancer Prev. 2014 Jan 1; 15(20):8571-6.
7. Uppugalla S, Male U, Srinivasan P. Design and synthesis of heteroatoms doped carbon/polyaniline hybrid material for high performance electrode in supercapacitor application. Electrochimica Acta. 2014 Nov 10;146:242-8.
8. Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: a food plant with multiple medicinal uses. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007 Jan;21(1):17-25.
9. Amaglo NK, Bennett RN, Curto RB, Rosa EA, Turco VL, Giuffrida A, Curto AL, Crea F, Timpo GM. Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera L., grown in Ghana. Food Chemistry. 2010 Oct 15; 122(4):1047-54.
10. Uppugalla S, Srinivasan P. High-performance supercapacitor coin cell: polyaniline and nitrogen, sulfur-doped activated carbon electrodes in aqueous electrolyte. Journal of Solid State Electrochemistry. 2019 Jan;23(1):295-306.
11. Mahmud I, Chowdhury K, Boroujerdi A. Tissue-specific metabolic profile study of Moringa oleifera L. using nuclear magnetic resonance spectroscopy. Plant tissue culture & biotechnology/Bangladesh Association for Plant Tissue Culture & Biotechnology; BAPTC&B. 2014 Jun;24(1):77.
12. Male U, Uppugalla S, Srinivasan P. Effect of reduced graphene oxide–silica composite in polyaniline: electrode material for high-performance supercapacitor. Journal of Solid State Electrochemistry. 2015 Nov;19(11):3381-8.
13. Bhattacharya SB, Das AK, Banerji N. Chemical investigations on the gum exudate from sajna (Moringa oleifera). Carbohydrate research. 1982 Apr 16;102(1):253-62.
14. Nepolean P, Anitha J, Emilin RR. Isolation, analysis and identification of phytochemicals of antimicrobial activity of Moringa oleifera Lam. Current biotica. 2009;3(1):33-7.
15. Rastogi R, Mehrotra B. Compendium of Indian Medicinal Plants published by Central Drug Research Institute. Lucknow and National Institute of Sciences Communication and Information Resources, New Delhi. 1990;1994(6):395-8.
16. Mishra G, Singh P, Verma R, Kumar S, Srivastav S, Jha KK, Khosa RL. Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: An overview. Der Pharmacia Lettre. 2011;3(2):141-64.
17. Gupta S, Jain R, Kachhwaha S, Kothari SL. Nutritional and medicinal applications of Moringa oleifera Lam.—Review of current status and future possibilities. Journal of Herbal Medicine. 2018 Mar 1; 11:1-1.
18. Uppugalla S, Srinivasan P. Polyaniline nanofibers and porous Ni [OH] 2 sheets coated carbon fabric for high performance super capacitor. Journal of Applied Polymer Science. 2019 Nov 5;136(41):48042.
19. Fuglie LJ. The miracle tree: Moringa oleifera, natural nutrition for the tropics.
20. Sairam TV. Home remedies, Vol II: A Handbook of Herbal Cures for Commons Ailments.
21. Sreelatha S, Padma PR. Antioxidant activity and total phenolic content of Moringa oleifera leaves in two stages of maturity. Plant foods for human nutrition. 2009 Dec;64(4):303-11.
22. Haristoy X, Fahey JW, Scholtus I, Lozniewski A. Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori. Planta medica. 2005 Apr;71(04):326-30.
23. Mahato DK, Kargwal R, Kamle M, Sharma B, Pandhi S, Mishra S, Gupta A, Mahmud MC, Gupta MK, Singha LB, Kumar P. Ethnopharmacological properties and Nutraceutical potential of Moringa oleifera. Phytomedicine Plus. 2022 Feb 1;2(1):100168.
24. Hannan MA, Kang JY, Mohibbullah M, Hong YK, Lee H, Choi JS, Choi IS, Moon IS. Moringa oleifera with promising neuronal survival and neurite outgrowth promoting potentials. Journal of ethnopharmacology. 2014 Feb 27;152(1):142-50.
25. Nandave M, Ojha SK, Joshi S, Kumari S, Arya DS. Moringa oleifera leaf extract prevents isoproterenol-induced myocardial damage in rats: evidence for an antioxidant, antiperoxidative, and cardioprotective intervention. Journal of medicinal food. 2009 Feb 1;12(1):47-55.
26. Muangnoi C, Chingsuwanrote P, Praengamthanachoti P, Svasti S, Tuntipopipat S. Moringa oleifera pod inhibits inflammatory mediator production by lipopolysaccharide-stimulated RAW 264.7 murine macrophage cell lines. Inflammation. 2012 Apr;35(2):445-55.
27. Uppugalla S, Boddula R, Srinivasan P. Methyl triphenylphosphonium permanganate as a novel oxidant for aniline to polyaniline-manganese (II, IV) oxide: material for high performance pseudocapacitor. Journal of Solid State Electrochemistry. 2018 Feb;22(2):407-15.
28. Lipipun V, Kurokawa M, Suttisri R, Taweechotipatr P, Pramyothin P, Hattori M, Shiraki K. Efficacy of Thai medicinal plant extracts against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral research. 2003 Nov 1;60(3):175-80.
29. Efstratiadis G, Divani M, Katsioulis E, Vergoulas G. Renal fibrosis. Hippokratia. 2009 Oct;13(4):224.
30. Kumar PS, Mishra D, Ghosh G, Panda CS. Medicinal uses and pharmacological properties of Moringa oleifera. International Journal of Phytomedicine. 2010 Jul 1;2(3).
31. Fakurazi S, Hairuszah I, Nanthini U. Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food and chemical toxicology. 2008 Aug 1;46(8):2611-5.
32. Gilani AH, Aftab K, Suria A, Siddiqui S, Salem R, Siddiqui BS, Faizi S. Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera. Phytotherapy research. 1994 Mar; 8(2):87-91.
33. Nanjappaiah HM, Shivakumar H. Prophylactic and curative effects of Moringa oleifera Lam. pods in CCl4 damaged rat liver. Indian J Nat Prod Resours. 2012;3:541–6
34. Pari L, Kumar NA. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. Journal of Medicinal Food. 2002 Sep 1;5(3):171-7.
35. Suzana D, Suyatna FD, Andrajati R, Sari SP, Mun’im A. Effect of Moringa oleifera leaves extract against hematology and blood biochemical value of patients with iron deficiency anemia. Journal of Young Pharmacists. 2017;9(1s):S79.
36. Goyal BR, Goyal RK, Mehta AA. Investigation into the mechanism of anti-asthmatic action of Moringa oleifera. Journal of dietary supplements. 2009 Nov 13;6(4):313-27.
37. Mahajan SG, Mehta AA. Effect of Moringa oleifera Lam. seed extract on ovalbumin-induced airway inflammation in guinea pigs. Inhalation toxicology. 2008 Jan 1;20(10):897-909.
Published
05/12/2022
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M, R. K., N. M, M. V, U. B. S, M. C, B. D. R, and R. B. “A Pharmacological Approaches on Moringa Oleifera Plant- a Brief Review ”. International Journal of Health Care and Biological Sciences, Vol. 3, no. 4, Dec. 2022, pp. 80-85, doi:10.46795/ijhcbs.v3i4.368.
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