THE ROLE OF SESAME OIL IN PROTECTION AGAINST TOXICITY OF CARBON TETRACHLORIDE
Abstract
The effect of carbontetrachloride (CCl4) with or without sesame oil on liver and kidney functions parameters and some biochemical indices of male rabbits were investigated.Levels of total protein and albumin showed a significant decrease after treatment with carbon tetrachloride.But their levels increased significantly after treatment with the combination of CCl4 and sesame oil. Levels of bilirubin increased significantly but decreased after treatment with the combination of CCL4 and sesame oil. Levels of ALT, AST, ALK, ACP and LDH increased significantly after treatment with carbon tetrachloride.Their levels decreased significantly after treatment with the combination of CCl4 and sesame oil compared to control. Glucose in serum of male rabbits decreased significantly after treatment with CCl4 compared to control.
Keywords:
Carbontetrachloride, Liver Functions, Kidney Functions, Carbon Tetrachloride
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References
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Al-Sayed, E., El-Lakkany, N.M., Seif el-Din, S.H., (2014). Hepatoprotective and antioxidant activity of Melaleucastyphelioides on carbon tetrachloride-induced hepatotoxicity in mice. Pharm Biol 52:1581–90.
Liu, Q., Baohua, K. and Li G. (2011). Hepatoprotective and antioxidant effects of porcine plasma protein hydrolysates on carbon tetrachloride-induced liver damage in rats. Food ChemToxicol 49:1316–21.
Adesanoye O.A. and Farombi, E.O. (2010). Hepatoprotective effects of Vernoniaamygdalina (Astereaceae) in rats treated with carbon tetrachloride. ExpToxicolPathol 62:197–206.
HSDB, Hazardous Substances Data Base. National Library of Medicine, 2000. http://toxnet.nlm.nih.gov/cgibin/ sis/htmlgen.
Weber, L.W., Boll, M. and Stampfl, A. (2003). Hepatotoxicity and mechanism of action ofhaloalkanes: carbon tetrachloride as a toxicological model. Institute of Toxicology, GSF-National Research Center for Environment and Health, Munich. Crit Rev Toxicol. 33:105-36.
Sharif, M.R., Alizagar, J., Sharif, A.(2013). Evaluation of the wound healing activity of sesame oil extracts in rats. World. J. Med. Sci. g. 74-78.
Hsu, D.Z., Chu, P.y., Jou, I.M. (2016). Enteral sesame oil therapeutically relieves disease severity in rat experimental osteoarthritis. Food Nut. Res. 60, 29807.
Nishant, P., Visavadiya, A.V.and Narasimhacharya, R.L. (2008). Sesame as a hypocholesteraemic and antioxidant dietary component. Food and Chemical Toxicology, 46, 1889–1895.
Imam,M.A., Ajao, M.S.,Ajibola,M.I.,Amin, A., Abdulmajeed, W.I.,Lawal, A.Z.,Ali-Oluwafuyi,A.,Olajide,O.J., Adana, M.Y. (2016). Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male wistar rats. Bull. Fac. Pharm.Cairo Univ. 54, 49-75.
Nakano, D., Itoh, C., Ishii, F., Kawanishi, H., Takaoka, M., Kiso, Y., (2003). Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats. Biol. Pharm. Bull. 26: 1701-5.
Katsuzaki, H., Kawakishi, S. and Osawa, T. (1994). Sesaminolglucosides in sesame seeds. Phytochemistry; 35:773-6.
Ryoji, Z., Kenzaburo, Y., Miho, A., Toshiyuki, C. and Hiroshi, H. (2007). Early induced, high-level interleukin-6 expression in the rat peritoneal cavity into which a hepatotoxicant carbon tetrachloride was administered. Toxicology Letters. 170: 42-48.
Shakoori, A.R., Aziz, F., Alam, J. and Ali, S.S. (1990). Toxic effects of talastar, a new synthetic pyrethroid, on blood and liver of rabbit, Pakistan J. Zool. 23: 289-300.
Armstrong, W.D. and Carr, C.W. (1964). Physiological Chemistry Laboratory Directions. 3rd ED. Burges Publishing Co., Minneapolis, Minnesota.
Doumas, B.T., Watson, W.A. and Biggs, H.G., (1977). Albumin standards and the measurement of serum albumin with bromocresol green. Clinic. Chem. Acta. 31: 87-96.
Trinder, P., (1969). Cited from Chmory Enzymatic glucose reagent set (colorimetric). Ann, Clin. Biochem. 6, 2.
Patton and Crouch (1977) Patton, C.J. and Crouch, S.R., (1977). Spectrophotometeric and kinetics investigation of the Berthelot reaction for determination of ammonia. Anal. Chem. 49: 464-469.
Henry, R.J., Cannon, D.C. and Winkelman, W., (1974). Clinical Chemistry Principels and Techniques, 11th ed. Happer and Row Publishers. p: 1629.
Pearlman, F.C. and Lee R.T.Y., (1974). Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents. Clin. Chem. 20, 447-453.
Reitman, S. and Frankel, S., (1975). A colorimetric method for the determination of serum glutamic oxalocetic and glutamic pyruvic transaminases. An. J. Clin. Path., 26: 56-63.
Principato, G.B., Asia, M.C., Talesa, V., Rosi, G.andGiovannini, E., (1985). Characterization of the soluble alkaline phosphatase from hepatopancreas of Squilla mantis L. Comp. Bioch. Physiol., 80: 801-804.
Moss, N.G., Powell, S.L., and Falk, R.J. (1985). Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats. ProcNatlAcadSci U S A, 82(23):8222-8226.
Paulson, D.S. (2008). Biostatistics and microbiology, A survival Pack. Springer, NewYork, USA, Rahman, NA (1968). A course in theoretical statistics.
Nevin, K.G. and Vijayammal, P.L., (2005). Effect of Aervalanata on solid tumor induced by DLA cells in mice. Fitoterapia. 74: 578-580.
Shahat, M. M. A. (2011).Evaluation of the protctive effects of Nigella Sativa and vitamin A in carbon tetrachloride-treated rats. Egypt. J. Exp. Biol. (Zool.), 7(2): 371 – 377.
Kanter, M., Coskun, O., Budancamanak, M. (2005). Hepatoprotective effects of Nigella sativa L and Urticadioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol., 11(42): 6684-6688.
Hussien, H.M., Abdou, H.M., and Yousef, M.I. (2012). Deleterious Effects of Cypermethrin on Rat Liver and Kidney: Protective Role of Sesame Oil. J Environ Sci Health B, 47 (4), 306-14.
Sahare, A.Y., Akare, S.C., Shende, M.A., Bondre, A.V. and Wanjari, A.D., (2006). Hepatoprotective activity of acacia ferrrgineadc leaves against carbon tetra chloride induced liver damage in rats. International Journal of Pharm.Tech. Research Coden (USA). 1: 962-965.
Rajesh, M.G. and Latha, M.S., (2004). Protective activity of GlycyrrhizaglabraLinn. on carbon tetrachloride-induced per oxidative damage. Ind. J. Parmacol. 36: 284-287
Jeong-Hyeon, K., Sei-Jung, L., Kye, T.L., and. Verniciflua, R., (2006). Stokes glycoprotein (36 kDa) has protective activity on carbon tetrachloride-induced liver injury in mice. Environmental Toxicology and Pharmacology. 22: 8-14.
Vitaglione, P., Morisco, F., Caporaso, N., and Fogliano, V., (2004). Dietary antioxidant compounds and liver health. Critical Reviews in Food Science and Nutrition. 44: 575-586.
Sharma, A.K., Bharti, S., and Bhatia, J. (2012). Sesamol alleviates diet-induced cardiometabolic syndrome in rats via up-regulating PPARgamma, PPARα and e-NOS. J NutrBiochem., 23:1482–1489.
Mokuda, O., Ubukata, E. and Sakamoto, Y., (1995). Impaired glucose uptake and intact gluconeogenesis in perfused rat liver after carbon tetrachloride injury. BiochemMol Med. 54: 38-42.
Ikeda, T., Takeuchi, T., Ito, Y., Murakami, I., Mokuda, O., Tominaga, M. and Mashiba, H., (1986). Secretion and degradation of insulin and glucagon in carbon tetrachloride-induced liver injury rats. AJP - Endocrinology and Metabolism. 251:660-663.
Karima, M.M.(2007). Possible Prophylactic Effects of Vitamin E or Lycopene Treatment on Renal Toxicity Induced by CCL4 Administrations in Albino Rats. World Journal of Zoology. 2: 19-28.
Tirkey, N., Pilkhwal, S., Kuhad, A. and Chopra, K. (2005). Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. B.M.C. Pharmacology. 5: 2.
Gavin, J.B. (1995). Assessment of renal function. The Md. GR. J. 23: 102-105.
Al-Sayed, E., El-Lakkany, N.M., Seif el-Din, S.H., (2014). Hepatoprotective and antioxidant activity of Melaleucastyphelioides on carbon tetrachloride-induced hepatotoxicity in mice. Pharm Biol 52:1581–90.
Liu, Q., Baohua, K. and Li G. (2011). Hepatoprotective and antioxidant effects of porcine plasma protein hydrolysates on carbon tetrachloride-induced liver damage in rats. Food ChemToxicol 49:1316–21.
Adesanoye O.A. and Farombi, E.O. (2010). Hepatoprotective effects of Vernoniaamygdalina (Astereaceae) in rats treated with carbon tetrachloride. ExpToxicolPathol 62:197–206.
HSDB, Hazardous Substances Data Base. National Library of Medicine, 2000. http://toxnet.nlm.nih.gov/cgibin/ sis/htmlgen.
Weber, L.W., Boll, M. and Stampfl, A. (2003). Hepatotoxicity and mechanism of action ofhaloalkanes: carbon tetrachloride as a toxicological model. Institute of Toxicology, GSF-National Research Center for Environment and Health, Munich. Crit Rev Toxicol. 33:105-36.
Sharif, M.R., Alizagar, J., Sharif, A.(2013). Evaluation of the wound healing activity of sesame oil extracts in rats. World. J. Med. Sci. g. 74-78.
Hsu, D.Z., Chu, P.y., Jou, I.M. (2016). Enteral sesame oil therapeutically relieves disease severity in rat experimental osteoarthritis. Food Nut. Res. 60, 29807.
Nishant, P., Visavadiya, A.V.and Narasimhacharya, R.L. (2008). Sesame as a hypocholesteraemic and antioxidant dietary component. Food and Chemical Toxicology, 46, 1889–1895.
Imam,M.A., Ajao, M.S.,Ajibola,M.I.,Amin, A., Abdulmajeed, W.I.,Lawal, A.Z.,Ali-Oluwafuyi,A.,Olajide,O.J., Adana, M.Y. (2016). Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male wistar rats. Bull. Fac. Pharm.Cairo Univ. 54, 49-75.
Nakano, D., Itoh, C., Ishii, F., Kawanishi, H., Takaoka, M., Kiso, Y., (2003). Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats. Biol. Pharm. Bull. 26: 1701-5.
Katsuzaki, H., Kawakishi, S. and Osawa, T. (1994). Sesaminolglucosides in sesame seeds. Phytochemistry; 35:773-6.
Ryoji, Z., Kenzaburo, Y., Miho, A., Toshiyuki, C. and Hiroshi, H. (2007). Early induced, high-level interleukin-6 expression in the rat peritoneal cavity into which a hepatotoxicant carbon tetrachloride was administered. Toxicology Letters. 170: 42-48.
Shakoori, A.R., Aziz, F., Alam, J. and Ali, S.S. (1990). Toxic effects of talastar, a new synthetic pyrethroid, on blood and liver of rabbit, Pakistan J. Zool. 23: 289-300.
Armstrong, W.D. and Carr, C.W. (1964). Physiological Chemistry Laboratory Directions. 3rd ED. Burges Publishing Co., Minneapolis, Minnesota.
Doumas, B.T., Watson, W.A. and Biggs, H.G., (1977). Albumin standards and the measurement of serum albumin with bromocresol green. Clinic. Chem. Acta. 31: 87-96.
Trinder, P., (1969). Cited from Chmory Enzymatic glucose reagent set (colorimetric). Ann, Clin. Biochem. 6, 2.
Patton and Crouch (1977) Patton, C.J. and Crouch, S.R., (1977). Spectrophotometeric and kinetics investigation of the Berthelot reaction for determination of ammonia. Anal. Chem. 49: 464-469.
Henry, R.J., Cannon, D.C. and Winkelman, W., (1974). Clinical Chemistry Principels and Techniques, 11th ed. Happer and Row Publishers. p: 1629.
Pearlman, F.C. and Lee R.T.Y., (1974). Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents. Clin. Chem. 20, 447-453.
Reitman, S. and Frankel, S., (1975). A colorimetric method for the determination of serum glutamic oxalocetic and glutamic pyruvic transaminases. An. J. Clin. Path., 26: 56-63.
Principato, G.B., Asia, M.C., Talesa, V., Rosi, G.andGiovannini, E., (1985). Characterization of the soluble alkaline phosphatase from hepatopancreas of Squilla mantis L. Comp. Bioch. Physiol., 80: 801-804.
Moss, N.G., Powell, S.L., and Falk, R.J. (1985). Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats. ProcNatlAcadSci U S A, 82(23):8222-8226.
Paulson, D.S. (2008). Biostatistics and microbiology, A survival Pack. Springer, NewYork, USA, Rahman, NA (1968). A course in theoretical statistics.
Nevin, K.G. and Vijayammal, P.L., (2005). Effect of Aervalanata on solid tumor induced by DLA cells in mice. Fitoterapia. 74: 578-580.
Shahat, M. M. A. (2011).Evaluation of the protctive effects of Nigella Sativa and vitamin A in carbon tetrachloride-treated rats. Egypt. J. Exp. Biol. (Zool.), 7(2): 371 – 377.
Kanter, M., Coskun, O., Budancamanak, M. (2005). Hepatoprotective effects of Nigella sativa L and Urticadioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats. World J Gastroenterol., 11(42): 6684-6688.
Hussien, H.M., Abdou, H.M., and Yousef, M.I. (2012). Deleterious Effects of Cypermethrin on Rat Liver and Kidney: Protective Role of Sesame Oil. J Environ Sci Health B, 47 (4), 306-14.
Sahare, A.Y., Akare, S.C., Shende, M.A., Bondre, A.V. and Wanjari, A.D., (2006). Hepatoprotective activity of acacia ferrrgineadc leaves against carbon tetra chloride induced liver damage in rats. International Journal of Pharm.Tech. Research Coden (USA). 1: 962-965.
Rajesh, M.G. and Latha, M.S., (2004). Protective activity of GlycyrrhizaglabraLinn. on carbon tetrachloride-induced per oxidative damage. Ind. J. Parmacol. 36: 284-287
Jeong-Hyeon, K., Sei-Jung, L., Kye, T.L., and. Verniciflua, R., (2006). Stokes glycoprotein (36 kDa) has protective activity on carbon tetrachloride-induced liver injury in mice. Environmental Toxicology and Pharmacology. 22: 8-14.
Vitaglione, P., Morisco, F., Caporaso, N., and Fogliano, V., (2004). Dietary antioxidant compounds and liver health. Critical Reviews in Food Science and Nutrition. 44: 575-586.
Sharma, A.K., Bharti, S., and Bhatia, J. (2012). Sesamol alleviates diet-induced cardiometabolic syndrome in rats via up-regulating PPARgamma, PPARα and e-NOS. J NutrBiochem., 23:1482–1489.
Mokuda, O., Ubukata, E. and Sakamoto, Y., (1995). Impaired glucose uptake and intact gluconeogenesis in perfused rat liver after carbon tetrachloride injury. BiochemMol Med. 54: 38-42.
Ikeda, T., Takeuchi, T., Ito, Y., Murakami, I., Mokuda, O., Tominaga, M. and Mashiba, H., (1986). Secretion and degradation of insulin and glucagon in carbon tetrachloride-induced liver injury rats. AJP - Endocrinology and Metabolism. 251:660-663.
Karima, M.M.(2007). Possible Prophylactic Effects of Vitamin E or Lycopene Treatment on Renal Toxicity Induced by CCL4 Administrations in Albino Rats. World Journal of Zoology. 2: 19-28.
Tirkey, N., Pilkhwal, S., Kuhad, A. and Chopra, K. (2005). Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. B.M.C. Pharmacology. 5: 2.
Gavin, J.B. (1995). Assessment of renal function. The Md. GR. J. 23: 102-105.
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30/06/2020
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M, B., A. Abdulnabi, and I. Abdelali. “THE ROLE OF SESAME OIL IN PROTECTION AGAINST TOXICITY OF CARBON TETRACHLORIDE”. International Journal of Health Care and Biological Sciences, Vol. 1, no. 1, June 2020, pp. 12-18, https://saapjournals.org/index.php/ijhcbs/article/view/13.
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