Optimize and Evaluate a Topical Gel Formulation with Solid Lipid Nanoparticles Loaded With Luliconazole

Siva Sai; Sasikanth Kothamasu

doi:10.37022/jiaps.v11i3.986

Bhusarapu Siva Sai Dept. of Pharmaceutics, SIMS College of Pharmacy, Mangaldas Nagar, Guntur-522001
Sasikanth Kothamasu Dept. of Pharmaceutics, SIMS College of Pharmacy, Mangaldas Nagar, Guntur-522001

DOI https://doi.org/10.37022/jiaps.v11i3.986

Abstract

New topical pharmaceutical options are critically needed for the treatment of fungal infections for prolonged therapeutic action. Luliconazole is a topical antifungal medicine for the treatment of fungal infection, but bioavailability barriers of luliconazole approach the development of effective topical luliconazole solid lipid nanoparticles (SLN) gel formulations with prolonged therapeutic potential against tropical fungal infections. SLN of luliconazole was prepared by the solvent diffusion method using stearic acid & poloxamer 188. The preformulation studies were conducted for the authenticity of the leading moiety. Thereafter, the prepared SLN, followed by gel formulations, was subjected to physicochemical evaluation and in vitro release profile of drug with kinetics studies. Thereafter, FTIR spectroscopy and scanning electron microscopy of the optimized formulation were done successfully. The results reveal that SLN F6 shows a significant entrapment efficacy with the highest entrapment of 92.13%±0.975. In particle size, size distribution, and zeta potential analysis, SLN exhibits a mean particle diameter of ~344.3 nm, with unimodal size distribution, a polydispersity index of 0.168, an intercept value of 0.98 with 92% peak intensity, and a zeta potential of ~18.8 mV. Further, G3 gel shows a higher entrapment efficacy with 91.39%±0.187 as compared to other formulations. The in vitro drug release profile of the G3 gel with 1.5% carbopol 934 w/v shows a sustained release profile with 79.57% ± 0.213 of the drug release even after 24 hrs of the time. It is concluded that the Luliconazole-loaded SLN-based gel formulation containing carbopol 934 1.5% w/v is suitable for topical application and may show a much better result of antifungal activity.

Keywords: Solid lipid nanoparticles loaded gel, drug content, pH of the gel, in vitro drug release study

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