Advancements in targeted drug delivery system: a review of novel approaches and carrier systems

Shasank D; Naga Subrahmanyam S; Suvarna Jyothi Navuduri

doi:10.37022/jiaps.v10i3.739

D.Shasank Ⅳ/Ⅳ B.Pharmacy, Koringa College of Pharmacy, Koringi, Kakinada District, A.P-533461
Naga Subrahmanyam S Professor, Department of Pharmacy Practice, Koringa College of Pharmacy, Koringi, Kakinada District, A.P-533461
Suvarna Jyothi Navuduri Professor and Principal, Koringa College of Pharmacy, Koringi, Kakinada District, A.P-533461

DOI https://doi.org/10.37022/jiaps.v10i3.739

Abstract

Targeted drug delivery systems have transformed pharmaceutical sciences by enhancing therapeutic efficacy, reducing side effects, and improving patient compliance. This review article explores the evolution of drug delivery systems, highlighting the importance of targeted approaches in disease management. We examine the principles, advantages, and limitations of various carrier systems, including liposomes, nanoparticles, monoclonal antibodies, niosomes, and quantum dots. These systems demonstrate potential in delivering drugs specifically to the site of action, minimizing toxicity, and enhancing therapeutic outcomes. The article discusses challenges and future directions in targeted drug delivery development, emphasizing the need for further research in nanotechnology and biomaterials. By understanding targeted drug delivery systems' potential, researchers and clinicians can develop more effective and safer treatments. This review provides insights into the current state of targeted drug delivery, highlighting its potential to revolutionize disease management. The development of novel carrier systems and approaches is crucial for improving therapeutic outcomes and patient quality of life.

Keywords: Targeted drug delivery, novel drug delivery systems, carrier systems, liposomes, nanoparticles, monoclonal antibodies, niosomes, and quantum dots

Downloads

Download data is not yet available.

References

1. Zishan M, Zeeshan A, Faisal S, et al. Vesicular drug delivery system used for liver diseases. World J Pharm Sci. 2017;5(4):28–35.
2. Thakur A, Roy A, Chatterjee S, Chakraborty P, Bhattacharya K, Mahata PP. Recent trends in targeted drug delivery. SMGroup. 2015.
3. Kumar A, Nautiyal U, Kaur C, Goel V, Piarchand N. Targeted drug delivery system: current and novel approach. Int J Pharm Med Res. 2017;5(2):448–454.
4. Akhtar M, Jamshaid M, Zaman M, Mirza AZ. Bilayer tablets: a developing novel drug delivery syste. J Drug Deliv Sci Technol. 2020;60:102079. doi:

10.1016/j.jddst.2020.102079 [DOI]
5. Kwon IK, Lee SC, Han B, Park K. Analysis on the current status of targeted drug delivery to tumors. J Control Release. 2012;164:108–114. doi: 10.1016/j.jconrel.2012.07.010 [DOI] [PMC free article] [PubMed]
6. Yoo J, Park C, Yi G, Lee D, Koo H. Active targeting strategies using biological ligands for nanoparticle drug delivery systems. Cancers. 2019;11:640. doi: 10.3390/cancers11050640 [DOI] [PMC free article] [PubMed]
7. Ali Y, Alqudah A, Ahmad S, Hamid SA, Farooq U. Macromolecules as targeted drugs delivery vehicles: an overview. Des Monomers Polym. 2015;22:1,91–97. [DOI] [PMC free article] [PubMed]
8. Mishra N, Pant P, Porwal A, Jaiswal J, Samad MA, Tiwari S. Targeted drug delivery: a review. Am J PharmTech Res. 2016;6(1).
9. Mishra N, Pant P, Porwal A, Jaiswal J, Samad MA, Tiwari S. Targeted drug delivery: a review. Am J PharmTech Res. 2016;6(1).
10. Rani K, Paliwal SA. Review on targeted drug delivery: its entire focus on advanced therapeutics and diagnostics. Sch J App Med Sci. 2014;2(1C):328–331.
11. Gujral S, Khatri S. A review on basic concept of drug targeting and drug carrier system. IJAPBC. 2013;2(1).
12. Gujral S, Khatri S. A review on basic concept of drug targeting and drug carrier system. IJAPBC. 2013;2(1).
13. Mahajan HS, Patil SB, Gattani SG, Kuchekar BS. Targeted drug delivery systems. Pharma Times. 2007;39(2).
14. Vyas SP, Khar RK. Targeted & Controlled Drug Delivery: Novel Carrier Systems. New Delhi, India: CBS Publishers & Distributors; 2004.
15. Manish G, Vimukta S. Targeted drug delivery system: a review. Res J Chem Sci. 2011;1(2):135–138.
16. Bhargav E, Madhuri N, Ramesh K, Manne A, Ravi V. Targeted drug delivery - a review. World J Pharm Pharm Sci. 2013;3(1):150–169.
17. Kannagi R, Izawa M, Koike T, Miyazaki K, Kimura N; Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis. Cancer Science, 2004; 95: 377– 384
18. Mishra N, Pant P, Porwal A, Jaiswal J, Samad MA, Tiwari S. Targeted drug delivery: a review. Am J PharmTech Res. 2016;6(1).
19. Rani K, Paliwal SA. Review on targeted drug delivery: its entire focus on advanced therapeutics and diagnostics. Sch J App Med Sci. 2014;2(1C):328–331.
20. Sagnella, S.; Drummond, C. Drug Delivery: A Nanomedicine Approach. Australian Biochemist. [Online] 2012, 43, 5–8, 20. The Australian Society for Biochemistry and Molecular
Biology.
21. Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of Industrial Pharmacy. In Roop Khar, Vyas SP, Farhan A, Jain Gaurav, editors. Novel Drug Delivery Systems, 3 rd ed, Varghese Publishing House; 2014. p. 872-906.
22. Jaya A, Shubhini S,Anubha K. Targeting : New Potential Carriers for Targeted Drug Delivery System, Int. J. Pharm. Sci. Rev. Res. 2011;8(2):117-123

23. Gupta M, Sharma V. Targeted drug delivery system: A Review, Res. J. Chem. Sci. 2011;1(2):135 – 138.
24. Freeman AI, Mayhew E. Targeted drug delivery. Cancer. 1986 Jul 15;58(S2):573-83.
25. Peter A. Ward, Methods of Producing Monoclonal antibodies, 4-9.
26. Mujoriya RZ, Dhamandeb K, Bodla RB. Niosomal drug delivery systems-a review. Int J Appl Pharm 2011;3:7-10.
27. Rutik Naganath Ghadge, Manisha B. Parhad, Dr.Gajanan S.Sanap`Review: Niosomal Drug Delivery Systems ' World Journal Of pharmaceutical Research, 2023; Vol. 12(5): page no. 680-691.
28. Allen TM, Cullis PR; Drug Delivery Systems: Entering the Mainstream. Science, 2004;303 (5665): 1818-1822.
29. S. Ghaderi, B. Ramesh, A.M. Seifalian Fluorescence nanoparticles “quantum dots” as drug delivery system and their toxicity: a review. J.Drug Target, 19 (7) (2011 Aug 22),pp. 475-486.