Evaluation of antidepressant activity of ethanolic extract of bacopa monnieri in swiss albino mice

Madhava Kumari  M; Renuka B

doi:10.37022/jiaps.v10i3.729

M.Madhava Kumari Department of Pharmacology, Avanthi Institute of Pharmaceutical Sciences, Tagarapuvalasa, Vijayanagaram, A.P, India
B. Renuka Department of Pharmacology, Avanthi Institute of Pharmaceutical Sciences, Tagarapuvalasa, Vijayanagaram, A.P, India

DOI https://doi.org/10.37022/jiaps.v10i3.729

Abstract

Depression is a common symptom of mental illness. Typical symptoms include a low mood, loss of appetite, feelings of guilt or inadequacy, trouble sleeping or restlessness, and lack of energy. Mimosa pudica is traditionally used to treat a variety of ailments due to its numerous healing properties. The purpose of this study was to deepen our understanding of the antidepressant activity of Bacopa monnieri. Researchers investigated the potential of an ethanolic extract of Bacopa monnieri (EEBM) to alleviate depression in Swiss albino mice. Imipramine was used as the standard drug for comparison. Phytochemical analysis revealed the presence of glycosides, phenols, tannins, alkaloids, flavonoids, and carbohydrates in the extract. EEBM caused no mortality when administered orally at a dose of 2000 mg/kg, despite some notable behavioral effects. At a dose of 400 mg/kg, EEBM significantly reduced immobility time in both the Forced Swim Test (FST) and the Tail Suspension Test (TST). The decreased immobility time observed in these tests indicates that EEBM exhibits superior antidepressant activity, likely due to enhanced central 5-HT (serotonin) or catecholamine neurotransmission.

Keywords: Bacopa monnieri, Antidepressant activity, Ethanolic extract, Forced Swim Test (FST), Tail Suspension Test (TST), Neurotransmission

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