Evaluation of antiobesity activity of justicia tranquebariensis on progesterone-induced obese rats

Jeevana K; Radhika C

doi:10.37022/jiaps.v8i3.545

K Jeevana Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.
C Radhika Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.

DOI https://doi.org/10.37022/jiaps.v8i3.545

Abstract

Obesity is characterized as abnormal or excessive fat deposition in adipose tissue and is a chronic disorder of carbohydrate and fat metabolism and poses a risk to the health and well-being of humans. Natural herbal products for weight reduction may be effective in the treatment of obesity and associated disorders. Therefore, the present study was to investigate the phytochemical screening, anti oxidant and anti-obesity activity of Justicia tranquebariensis extract. The phytochemical screening Justicia tranquebariensis showed that the presence of saponins, flavonoids, steroids, terpenoids, polyphenol, and alkaloids in ether, ethanol and aqueous extracts. Quantitative analysis of phenol and flavonoids was carried out. Significant amount of flavonoids and phenols were present. The anti-obesity activity of Justicia tranquebariensis was proved by inhibition of lipase. Overall, it was concluded from the present study that Justicia tranquebariensis extract possesed rich source of phytochemicals and hence anti-obesity activity.

Keywords: Justicia tranquebariensis, phytochemical screening, anti-obesity activity

Downloads

Download data is not yet available.

Author Biographies

K Jeevana, Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.

Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.

C Radhika, Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.

Department of Pharmacology, Sri Venkateswara College of Pharmacy, Chittoor, Andhra Pradesh, India.

References

1. Alaca, K., Okumuş, E., Bakkalbaşi, E., & Javidipour, I. (2022). Phytochemicals and antioxidant activities of twelve edible wild plants from Eastern Anatolia, Turkey. Food Science and Technology, 42, e18021. http://dx.doi.org/10.1590/fst.18021.
2. Padma, R., Parvathy, N. G., Renjith, V., Kalpana, P. R., & Rahate, P. (2013). Quantitative estimation of tannins, phenols and antioxidant activity of methanolic extract of Imperata cylindrical. International Journal of Research in Pharmaceutical Sciences, 4(1), 73-77.
3. Singleton, V. L., Orthofer, R., & Lamuela-Raventós, R. M. (1999). Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Methods in Enzymology, 299, 152178. http://dx.doi.org/10.1016/S0076-6879(99)99017-1.
4. Bag, G. C., Devi, P. G., & Bhaigyabati, T. H. (2015). Assessment of total flavonoid content and antioxidant activity of methanolic rhizome extract of three Hedychium species of Manipur valley. International Journal of Pharmaceutical Sciences Review and Research, 30(1), 154-159.
5. Sharma, O. P., & Bhat, T. K. (2009). DPPH antioxidant assay revisited. Food Chemistry, 113(4), 1202-1205. http://dx.doi.org/10.1016/j. foodchem.2008.08.008.
6. Marcocci, L. Maguire, J .J., Droyl-lefaix, M. T. and Packer, L. (1994). The nitric oxide scavenging properties of Ginkgo biloba extract. Biochem. Biophy. Res. commum., 201:748-755.
7. Lee, H. E., Yang, G., Han, S. H., Lee, J. H., and Jang, J. K., (2018). Anti-obesity potential of Glycyrrhiza uralensis and licochalcone A through induction of adipocyte browning. Biochem. Biophysical Res. Commun. 503 (3), 2117–2123.
8. Huang, L., Zhang, J., Zhu, X., Mi, X., Li, Q., Gao, J., et al. (2021). The phytochemical rhein mediates M(6)a-independent suppression of adipocyte differentiation. Front. Nutr. 8, 756803.
9. Latha, B. P., (2011). Therapeutic efficacy of Achyranthes aspera saponin extract in high fat diet induced hyperlipidaemia in male wistar rats. Afr. J. Biotechnol. 10 (74), 17038–17042.
10. Li, R., Lan, Y., Chen, C., Cao, Y., Huang, Q., Ho, C. T., et al. (2020). Anti-obesity effects of capsaicin and the underlying mechanisms: A review. Food & Funct. 11 (9), 7356–7370.