Formulation and evaluation of controlled porosity oral osmotic pump tablets of furosemide
Abstract
Oedema is an abnormal accumulation of fluid in the interstitium located beneath the skin and in the cavities of the body which can cause severe pain. Furosemide has been shown to be effective and safe in patients with hypertension and/ or coronary heart disease. Osmotic pump tablets deliver the drug in an optimized manner to maintain drug concentration within the therapeutic window and minimize toxic effects. The major objective of the study was to prepare and evaluate oral controlled porosity osmotic pump tablets of furosemide, to reduce the dosing frequency and thereby side effects, and to release the drug for a prolonged period in a controlled manner that is independent of pH and hydrodynamic activity. Pre-formulation studies and pre-compression parameters of tablet blends of osmotic pump tablets of furosemide were carried out. Oral-controlled porosity osmotic pump tablets of furosemide were prepared and subjected to different evaluation tests. Precompression parameters indicated that granules have a good flow property. All the formulations showed good mechanical strength. All the nine formulations showed a drug release of more than 60% in the 12th hour. Optimised formulation showed a drug release of 99.21% in 12th hr. Stability studies conducted indicate that the product is stable.
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References
2. Stanley S. Davis, Formulation strategies for absorption windows, Drug del. Tech. 2005;10: 4.
3. Lachman L: Liberman H.A; Kang J.1, the theory and practice of IR, third edition, Varghese publishment house, Mumbai :296-302, (1990)
4. Li X, Jasti BR. Osmotic controlled drug delivery systems Design of controlled release of drug delivery systems. McGraw Hill, 2006: 203-29.
5. Stutuigupta: osmotic pumps: a review: International Journal of pharmacy 2011; 6:1-8
6. Vyas, S.P. and Khar R.K., Controlled drug delivery Concepts and Advances, 1st Edn, VallabhPrakashan, New Delhi: 477-502, (1994)
7. Rastogi, S.K., Vaya N and Mishra B, Osmotic pump: A novel concept in rate controlled oral drug delivery, Eastern Pharmacist. 1995;38: 79-82.
8. Lin, Y. and Ho, H., Investigations on the drug releasing mechanism from an asymmetric membrane coated capsule with an in situ formed delivery orifice, J. Contr. Release. 2003;89:57-69.
9. Verma, R.K., Krishna, D.M. and Garg, S., Formulation aspects in the development of osmotically controlled oral drug delivery systems, J. Contr. Release.2002;79:7- 27.
10. Zentner, G.M., Rork, G.S., and Himmelstein K.J.US Patent No 4968507, 1990
11. NaushadAlama, SarwarBegb, Mohammad Rizwanc, AkifaAhmadd, Mucoadhesive elementary osmotic pump tablets of trimetazidine for controlled drug delivery and reduced variability in oral bioavailability, Drug Development and Industrial Pharmacy. 2015; 4(4): 692-702.
12. Ravi Ghosh, AmitavaGhosh. A review on osmotic pump. Journal of Applied Pharmaceutical Science 2011; 1(2): 38-49.
13. En-Xian Lul, Zhi-Qiang Jiang, Qi-Zhi Zhang, Xin-GuoJiang,oralsmoticpmup tablets: A review, Journal of Controlled Release. 2003; 92: 375-382.
14. Stuti G, Ravindra PS, RohitashvaS.Review on osmotic pump tablets, International Journal of Comprehensive Pharmacy 2011; 6: 1.
15. Amir M. Razaghia& Joseph B. Schwartzb, Release of Cyclobenzaprine Hydrochloride from OsmoticallyRupturable Tablets, Drug Development and Industrial Pharmacy. 2002;28(6) : 301-313.
16. Sanap LS, Savkare AD, Controlled porosity osmotic pump a review. Inter J Pharma Res Dev 2014;5(12):71-80.
17. TanmoyGhosh, AmitavaGhosh Controlled porosity osmotic pump a review. Journal: of Applied Pharmaceutical Science. 2011; 1 (2): 38-49.
18. Sanap LS, Savkare AD. Controlled porosity osmotic pump a review. Inter J Pharma Res Dev. 2014;5(12):71-80.
19. ZentnerGM,McClelland GA, Sutton SC. Controlled porosity solubility and resin modulated osmotic drug delivery systems for release of diltiazem hydrochloride. J Control Release. 1991;16:237-44
20. Harnish Patel, Dr. Upendra Patel, HirenKadikar, Bhavin Bhimani, Dhiren Daslaniya, Ganshyam Patel. Formulation and evaluation of controlled porosity osmotic pump tablets of Glimepiride. International Journal of Drug Delivery 4. 2012: 113-124.
21. Jadav MM, Teraiya SR, Patel KN, Patel BA, Patel PA. Formulation and Evaluation of Oral Controlled Porosity Osmotic Pump Tablet of Zaltoprofen. International Journal for Pharmaceutical Research Scholars (IJPRS) (2012)ISSN No: 2277-7873.
22. ZalaparthHarishkumar, Patel Ghansyam V, BhimaniBhavin V, KadhikarHiren K, Dr Patel upendhra K. Formulation and evaluation of osmotic pump tablet of pregabalin, International journel of pharmaceutical research and bio science, IJPRBS. 2015;4(2): 305-319.
23. Hardik Patel, M.M Patel. Formulation and Evaluation of Controlled Porosity Osmotic Drug Delivery System of CarvedilolPhosphate. JPSBR.2012;2(2):77-82.
24. Zonghe Zhao, Chao Wu, Ying Zhao, YannaHao,Ying Liu, wenming Zhao. Development of an oral push pull osmotic pump of fenofibrate loaded mesoporous silica nanoparticles. Dovepress. 2015;10(1): 1691-1701
25. K.Derakhshandeh, M. Ghasemnejadberenji, development and optimization of buspirone oral osmotic pump tablet. Research in pharmaceutical sciences. 2014; 9(4):233-241.
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