Formulation and evaluation of buccal film of an antihypertensive drug
Abstract
The aim of the study was to formulate and evaluate Losartan potassium buccal films, an angiotensin receptor blocker and is used to treat hypertension. Losartan potassium is having less bioavailability (33%), so the buccal films are expected to increase the bioavailability by avoiding hepatic metabolism. Ten formulations of buccal films were prepared by solvent casting method using HPMC K15 M as the main film-forming polymer in various proportions with various co-polymers such as Eudragit RL. 100, Carbopol 940, Ethyl cellulose. Physicochemical characteristics,in vitro buccal permeation, in vitro release study and residence time were evaluated. In vitro studies revealed that the release rate of Losartan potassium was higher for films containing HPMC K15 M and Eudragit RL100 in 3:1 ratio. The result of stability study indicated that no significant changes have occurredduring the period of study.
Keywords:
Losartan potassium, buccal films, HPMC K15 M, in vitro drug release, swelling index
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References
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23. Doshi Abha, Koliyote Sheeja, Joshi Bhagyashri. Design and Evaluation of Buccal Film of Diclofenac Sodium. IJPBS. 2011; 1(1):17-30.
24. Mishra, A, Ramteke .S. Formulation and Evaluation of Mucoadhesive Buccal Film of Flurbiprofen. Int J Pharm Tech Res. 2011; 3(3):1825-1830.
25. Bazigha K. Abdul Rasool, Saced A. Khan. In vitro Evaluation of Miconazole Mucoadhesive Buccal Films. IJAP. 2010; 2(4):23-26.
26. A. Semaltey, Mona Semaltey, U. Nautiyal. Formulation and Evaluation of Mucoadhesive Buccal Films of Enalapril Maleate. Indian J Pharm Sci. 2010;72(5):571-575.
27. M. Alagusundaram, B. Chengaiah, S. Ramkanth, S. Angala Parameswari, C. Madhu Sudhana Chetty, D. Dhachinamoorthi. Formulation and Evaluation of Mucoadhesive Buccal Films of Ranitidine. IJPRIF. 2009; 1(3):557-563.
28. R. Khanna, S. P. Agarwal, Alka Ahuja. Praparation and Evaluation of Mucoadhesive Buccal Films of Clotrimazole for Oral Candida Infections. Indian J Pharm Sci. 1997; 59(6):299-305.
29. Raymond C Rowe, Paul J Sheskey, Marian E Quinn. Handbook of Pharmaceutical Excipients. London: Pharmaceutical Press; 2009.
30. Sakellariou P, Rowe RC. Interations in Cellulose Derivative Films for Oral Drug Delivery. Prog Polym Sci.1995; 20(1):889-942.
31. Parth S. Patel, Ashish M. Parmar, Nilang S. Doshi, Hardik V. Patel, Raxit R. Patel, Chetan Nayee. Buccal Drug Delivery System: A Review. Int J Drug Dev & Res. 2013; 5(3):35-48.
32. Dipak Malpure Rajaram, Sharada Deore Laxman. Buccal Mucoadhesive Films: A Review. Sys Rev Pharm. 2017; 8(1):31-38.
33. Amir H. Shojaei. Buccal Mucosa as a Route for Systemic Drug Delivery: A Review. J Pharm Pharmaceut Sci. 1998; 1(1):15-30.
2. Shubham Verma, Nitin Kumar, Pramod Kumar Sharma. Buccal Film: An Advance Technology for Oral Drug Delivery. Adv Bio Res. 2014; 8(6):260- 267.
3. Umesh. D. Shivhare, Parag. D. Bodkhe, Kishor P. Bhusari, Vijay B. Mathur. Formulation and Evaluation of Buccoadhesive Film of Losartan Potassium. Sch Res Libr Der Pharm Lett. 2010; 2(5):251-260.
4. Nishan N. Bobade, Sandeep C. Atram, Vikrant P. Wankhade, Dr. S. D. Pande, Dr. K.K. Tapar. A Review on Buccal Drug Delivery System. Int J PharmPharmac. Sci Res. 2013; 3(1):35-40.
5. Izhar Ahmed Syed, S. Krishna. Buccal Films Drug Delivery Device: A Review. Asian J Pharm Edu Res. 2013; 2(3):1-30.
6. Dipika Parmar, Dr. Upendra Patel, Bhavin Bhimani, Aditi Tripathi, Dhiren Daslaniya, Ghanshyam Patel. Orally Fast Dissolving Films as Dominant Dosage Form for Quick Release. Int J Pharm Res Bio Sci. 2012; 1(3):27-41.
7. Y. Indira Muzib, K. Srujana Kumari. Mucoadhesive Buccal Films of Glibenclamide: Development and Evaluation. Int J Pharm Inves. 2011; 1(1):42-49.
8. Prashant Deore, Rajveer Bhaskar, Monika Ola, Prakash Patil. Formulation and Evaluation of Nicotine Buccal Film. Int J Res Pharm Nano Sci. 2016; 5(6):39- 44.
9. Dipak Rajaram Malpure, Sharada Laxman Deore. Development and Characterization of Buccal Film of Candesartan. Pharm Methods. 2016; 7(2):75-88.
10. S. Sarojini, P. Ravikumar, S. Saranya, A. Dhivya, K. Manimaran, B. Jayanthi, M. Komala. Formulation Development of Olmesartan Medoxomil Mucoadhesive Buccal Film. Asian J pharm. 2016; 10(4):51-57.
11. Ajitha K Cheriyan, Sr. Daisy P. A, Noby Thomas, Praveen Raj, Liji Jacob, Boby Johns George, Sr. Betty Carla. Formulation and Evaluation of Cefpodoxime Proxetil Buccal Film. Int J Pharm Chem Analysis. 2015; 2(1):1- 13.
12. Ashish Gorle, Prafulla Patil, Rajveer Bhaskar, Monika Ola. Development and Evaluation of Buccal Film Containing Antihypertensive agent. Pharm Innov J. 2015: 4(1):53-60.
13. Ann Rose Augusthy, Vipin K. V, Sarath Chandran C, Thushara M.V, Shahin Muhammed T.K. Formulation and Evaluation of Mucoadhesive Buccal Film of Lisinopril. RRJPNT, 2014; 2(1):45-51.
14. K. R. Jadhave, A. Y. Pawar, A. S. Nile, Formulation and Evaluation of Buccal Film of Glimepiride. Int J Pharm Sci. 2014; 5(3):278-292.
15. Dr. Anna Balaji, B. Krishnaveni, Vishnuvardhan Goud. Formulation and Evaluation of Mucoadhesive Buccal Films of Atorvastatin Using Natural Protein. Int J Pharm Pharmac. Sci. 2014; 6(2):332-337.
16. Kalyani Prakasam, Rama Bukka. Evaluation of Cellulose Polymers for Buccal Film Formulation of Rasagiline. Asian J Pharm Clin Res. 2014: 7(3):83-88 17. Nagaveni Somepalli, Chandra Sekhar Moru, Dinesh Babu Gottipati, Vamshi Krishna Voruganti. Formulation and Evaluation of Buccal Films of
17. Salbutamol Sulphate. Mintage J Pharm Med Sci. 2013; 2(3):37-40.
18. Dr. L. K. Omaray. Formulation and Characterization of Bioadhesive Buccal Drug Delivery System of Testosterone. CTTS. 2013; 2(4):354-358.
19. Magdaline Tarai, Jaya Gopal Meher, Ansuman Patnaik, Dr. Paresh Mishra, Dr. H. Lalhlenmawia. Novel, Buccao-compatible Simvastatin Buccal Film: An Integrative Study of the Effect of Formulation Variables. J Sci Innov Res. 2013; 2(5):903-913,
20. P. Sandhya, Nazera Tazyeen, M. Sunitha, M. Sirisha, R. Sunil. Formulation and Evaluation of Buccal Films of Ketorolac Tromethamine. JGTPS. 2013; 4(3):1184-1192.
21. M. Komala, P. Shanmugapandiyan, N. Shalini, K. Hima Bindu, K. P Sampath Kumar, Debjit Bhowmik. Design and In vitro Evaluation of Buccal Film of Terfinadine. Pharm Innov. 2012; 1(7):73-77.
22. J. Ravi Kumar Reddy, Y. Indira Muzib, K. P. R. Chowdary. Formulation and Evaluation of Mucoadhesive Buccal Films of Amiloride Hydrochloride. 2012; 3(3):828-835.
23. Doshi Abha, Koliyote Sheeja, Joshi Bhagyashri. Design and Evaluation of Buccal Film of Diclofenac Sodium. IJPBS. 2011; 1(1):17-30.
24. Mishra, A, Ramteke .S. Formulation and Evaluation of Mucoadhesive Buccal Film of Flurbiprofen. Int J Pharm Tech Res. 2011; 3(3):1825-1830.
25. Bazigha K. Abdul Rasool, Saced A. Khan. In vitro Evaluation of Miconazole Mucoadhesive Buccal Films. IJAP. 2010; 2(4):23-26.
26. A. Semaltey, Mona Semaltey, U. Nautiyal. Formulation and Evaluation of Mucoadhesive Buccal Films of Enalapril Maleate. Indian J Pharm Sci. 2010;72(5):571-575.
27. M. Alagusundaram, B. Chengaiah, S. Ramkanth, S. Angala Parameswari, C. Madhu Sudhana Chetty, D. Dhachinamoorthi. Formulation and Evaluation of Mucoadhesive Buccal Films of Ranitidine. IJPRIF. 2009; 1(3):557-563.
28. R. Khanna, S. P. Agarwal, Alka Ahuja. Praparation and Evaluation of Mucoadhesive Buccal Films of Clotrimazole for Oral Candida Infections. Indian J Pharm Sci. 1997; 59(6):299-305.
29. Raymond C Rowe, Paul J Sheskey, Marian E Quinn. Handbook of Pharmaceutical Excipients. London: Pharmaceutical Press; 2009.
30. Sakellariou P, Rowe RC. Interations in Cellulose Derivative Films for Oral Drug Delivery. Prog Polym Sci.1995; 20(1):889-942.
31. Parth S. Patel, Ashish M. Parmar, Nilang S. Doshi, Hardik V. Patel, Raxit R. Patel, Chetan Nayee. Buccal Drug Delivery System: A Review. Int J Drug Dev & Res. 2013; 5(3):35-48.
32. Dipak Malpure Rajaram, Sharada Deore Laxman. Buccal Mucoadhesive Films: A Review. Sys Rev Pharm. 2017; 8(1):31-38.
33. Amir H. Shojaei. Buccal Mucosa as a Route for Systemic Drug Delivery: A Review. J Pharm Pharmaceut Sci. 1998; 1(1):15-30.
Published
30/11/2023
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How to Cite
Benedict, A., Paul, I. R., Mathews, M. M., & R, B. (2023). Formulation and evaluation of buccal film of an antihypertensive drug. Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 8(3-S), 75-80. https://doi.org/10.37022/jiaps.v8i3-S.528
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