Evaluation of anti-inflammatory activity and anti-oxidant potential of portulaca quadrifida linn.
Abstract
Portulaca quadrifidaL. (PQ) having the phytochemicals like Alkaloids, flavonoids, Saponins, tannins, glycosides, carbohydrates, aminoacids, triterpenoids. The present study was performed to evaluate the antioxidant and anti-inflammatory activities by using acetic acid induced vascular permeability model in mice & acetic acid induced colitis in rats significantly. PQ (100 mg/kg, p.o.) presented a significant anti-inflammatory activity towards acetic acid induced vascular permeability model in mice in comparison to Diclofenac sodium(10 mg/kg, s.c.) and acetic acid induced colitis in rats in comparison to 5-ASA. Our findings suggest that, PQ contains potential antioxidant and anti-inflammatory compounds which will aid us to conduct bioactivity guided isolation & characterization of leading compounds in due course.
Keywords:
Portulaca quadrifida Linn, mice, anti-inflammatory activity, Diclofenac
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References
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30. Wang, Zq, Frank Porreca, and Salvatore Cuzzocrea. 2004. A newly identified role for superoxide in inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics 309: 869–878. https://doi.org/10.1124/jpet.103.064154.increased.
31. Akbar, A., Y. Yiangou, P. Facer, J.R.F. Walters, P. Anand, and S. Ghosh. 2008. Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut 57: 923–929. https://doi.org/10.1136/gut.2007.138982.
32. 72. Ludwiczek, O., E. Vannier, I. Borggraefe, A. Kaser, B. Siegmund, C.A. Dinarello, and Herbert Tilg. 2004. Imbalance between interleukin-1 agonists and antagonists: Relationship to severity of inflammatory bowel disease. Clinical and Experimental Immunology 138: 323–329
33. Steidler, L., W. Hans, L. Schotte, S. Neirynck, F. Obermeier, W. Falk,W.Fiers, and E. Remaut. 2000. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289: 1352– 1355.
34. 74. Li, Zhi, De Kui Zhang, Wen Quan Yi, Qin Ouyang, You Qin Chen, and Hua Tian Gan. 2008. NF-KB p65 Antisense Oligonucleotides May Serve as a Novel Molecular Approach for the Treatment of Patients with Ulcerative Colitis. Archives of Medical Research 39. E l s e vi e r I n c : 729–73 4 .
35. Achitei, D., A. Ciobica, G. Balan, E. Gologan, C. Stanciu, and G. Stefanescu. 2013. Different profile of peripheral antioxidant enzymes and lipid peroxidation in active and non-active inflammatory bowel disease patients. Digestive Diseases and Sciences 58: 1244– 1249. https://doi.org/10.1007/s10620-012-2510-z.
36. Martín AR, Villegas I, SánchezHidalgo M, La Lastra D, Alarcón C. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. British Journal of Pharmacology 2006; 147(8): 873–885.
37. Berkhout M, Friederich P, van Krieken JH, Peters WH, Nagengast FM. Low detoxification capacity in the ileal pouch mucosa of patients with ulcerative colitis. Inflammatory Bowel Diseases 2006; 12(2): 112–126.
2. Matta s, wilbraham c, staley (1996) introduction to general, organic, and biological chemistry. Dc heath and company, toronto
3. Mcgrane, mm (2006). Carbohydrate metabolism: synthesis and oxidation. Missouri: saunders, elsevier. Pp. 258–277. Isbn 1-4160-0209-x.
4. Mulla, s. K., &swamy, p. (2010). Preliminary pharmacognostical and phytochemical evaluation of portulacaquadrifidalinn . International journal of pharmtech research, 2(3), 1699–1702.
5. Porth cm (2005) pathophysiology concepts of altered health states. 7th edn. Lippincott williams&wilkins, Philadelphia
6. M, s. K., ahmed, l., ¶mjyothi, s. (2010). Neuropharmacological effects of ethanolic extract of portulacaquadrifidalinn . In mice. International journal of pharmtech research, 2(2), 1386–1390.
7. Mccance kl, heuther se (2006) pathophysiology: the biological basis for disease in adults and children. 4th edn. Mosby, stlewis
8. Length, f. (2009). Preparation and antidiabetic activity of polysaccharide from portulaca oleracea l . African journal of biotechnology, 8(4), 569–573.
9. R.Medzhitov, “Origin and physiological roles of inflammation,” Nature, vol. 454, no. 7203, pp. 428–435, 2008.
10. M. White, “Mediators of inflammation and the inflammatory process,” Journal of Allergy and Clinical Immunology, vol. 103, no. 3, pp. S378–S381, 1999.
11. K. D. Rainsford, “Anti-inflammatory drugs in the 21st century,” Sub-Cellular Biochemistry, vol. 42, pp. 3–27, 2007.
12. S. Shah and V. Mehta, “Controversies and advances in nonsteroidal anti-inflammatory drug (NSAID) analgesia in chronic pain management,” Postgraduate Medical Journal, vol. 88, no. 1036, pp. 73–78, 2012.
13. K. Kiss, A. Bazylko, A. Filipek et al., “Oenothein B’s contribution to the anti-inflammatory and antioxidant activity of Epilobiumsp,” Phytomedicine, vol. 18, no. 7, pp. 557–560, 2011.
14. M.-H. Huang, B.-S. Wang, C.-S. Chiu et al., “Antioxidant, antinociceptive, and anti-inflammatory activities of Xanthii Fructus extract,” Journal of Ethnopharmacology, vol. 135, no. 2, pp. 545–552, 2011.
15. Paramita S, Kosala K, Dzulkifli D, Saputri DI, Wijayanti E. Anti-inflammatory activities of ethnomedicinal plants from Dayak Abai in North Kalimantan, Indonesia. Biodiversitas, 2017; 18(4):1556-1561
16. Shaikh RU, Pund MM, Gacche RN. Evaluation of anti-inflammatory activity of selected medicinal plants used in Indian traditional medication system in vitro as well as in vivo. J. of Trad and Complement Med, 2016; 6:355-361.
17. Su Y-D, Cheng C-H, Wen Z-H, Wu Y-C, Sung P-J. New anti-inflammatory sterols from a gorgonian Pinnigorgia sp. Bioorganic & Med Chem Lett, 2016; 26(13) :3060-3063
18. Lee, E. B., Li, D.W., Hyun, J. E., Kim, I. H., and Whang, W. K., Anti-inflammatory activity of methanol extract of Kalopanxpictus bark and its fractions. J. Ethnopharmacol., 77, 197- 201 (2001).
19. Olajide, O. A., Awe, S. O., Makinde, J. M., Ekhelar, A. I., Olusola. A., Morebise, O., and Okpako, D. T., Studies on the anti inflammatory, antipyretic and analgesic properties of Alstoniaboonei stem bark. J. Ethnopharmacol., 71(1-2), 179- 186 (2000).
20. Srinivasan, K., Muruganandan, S., Lal, J., Chandra, S., Tandan, S. K., and Prakash, V. R., Evaluation of anti-inflammatory activity of Pongamiapinnata leaves in rats. J. Ethnopharmacol., 78(2-3), 151-157 (2001).
21. Vane, J. R. and Botting, R. M., Anti-inflammatory drugs and their mechanism of action. Inflamm Res., 2, S78-87. (1998).
22. Singh, G. B., Kour, Sukhvir., Satti, N. K., Ata l, C. K. and Mahes~wari , J. K.: Anti-inflammatory activity of Euphorbia acaulis Roxb . J. Eth nopharmacol. 10: 225-233, 1984.
23. Singh, G. B. and Atal, C. K.: Pharmacology of an extract of salaiguggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent. Agents and Actions 18: 407-412, 1986.
24. Singh, G. B., Singh, Surjeet, Bani, S., Gupta, B.D. and Banerjee, S. K.: Anti-inflammatory activity of oleanolic acid in rats and mice. Pharm. Pharmacol. 44: 456-458,1992.
25. Singh, G. B., Bani, Sarang, Singh, Surjeet, Khajuria, A., Sharma, M. L., Gupta, B.D. and Bane rjee, S. K.: Anti-inflammatory activity of the irridoidskutkin, Picroside-I and Kutkoside from Picrorhizakurrooa. Phytotherapy Research 7: 402-407, 1993.
26. Singh, G. B., Singh, Surjeet and Bani, Sarang: Boswellic acids anti -inflammatory, anti-arthritic and ant i-pyretic. Drugs of Future 18: 307-309, 1993.
27. Singh, G. B. and Singh, Surjeet: Antiinflammatory activity of Lanneacoromandelica bark extract in rat s. Phytotherapy Research 8: 311-313, 1994 .
28. Singh, Surjeet, Bani, S., Khajuria, A., Sharma, M. L., Singh, G. B., Suri, A. K. and Srivastava, T. N.: Antiinflammatory activity of Paederiafoetida. Fitoterapia LXV: 357-365, 1994.
29. Maioli, N.A., A.C. Zarpelon, S.S. Mizokami, C. Calixto-Campos, C.F.S. Guazelli, M.S.N. Hohmann, F.A. Pinho-Ribeiro, T.T. Carvalho, M.F. Manchope, C.R. Ferraz, R. Casagrande, and W.A. Verri Jr. 2015. The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2. Brazilian Journal of Medical and Biological Research 48: 321–331. https://doi.org/ 10.1590/1414-431X20144187.
30. Wang, Zq, Frank Porreca, and Salvatore Cuzzocrea. 2004. A newly identified role for superoxide in inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics 309: 869–878. https://doi.org/10.1124/jpet.103.064154.increased.
31. Akbar, A., Y. Yiangou, P. Facer, J.R.F. Walters, P. Anand, and S. Ghosh. 2008. Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut 57: 923–929. https://doi.org/10.1136/gut.2007.138982.
32. 72. Ludwiczek, O., E. Vannier, I. Borggraefe, A. Kaser, B. Siegmund, C.A. Dinarello, and Herbert Tilg. 2004. Imbalance between interleukin-1 agonists and antagonists: Relationship to severity of inflammatory bowel disease. Clinical and Experimental Immunology 138: 323–329
33. Steidler, L., W. Hans, L. Schotte, S. Neirynck, F. Obermeier, W. Falk,W.Fiers, and E. Remaut. 2000. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289: 1352– 1355.
34. 74. Li, Zhi, De Kui Zhang, Wen Quan Yi, Qin Ouyang, You Qin Chen, and Hua Tian Gan. 2008. NF-KB p65 Antisense Oligonucleotides May Serve as a Novel Molecular Approach for the Treatment of Patients with Ulcerative Colitis. Archives of Medical Research 39. E l s e vi e r I n c : 729–73 4 .
35. Achitei, D., A. Ciobica, G. Balan, E. Gologan, C. Stanciu, and G. Stefanescu. 2013. Different profile of peripheral antioxidant enzymes and lipid peroxidation in active and non-active inflammatory bowel disease patients. Digestive Diseases and Sciences 58: 1244– 1249. https://doi.org/10.1007/s10620-012-2510-z.
36. Martín AR, Villegas I, SánchezHidalgo M, La Lastra D, Alarcón C. The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. British Journal of Pharmacology 2006; 147(8): 873–885.
37. Berkhout M, Friederich P, van Krieken JH, Peters WH, Nagengast FM. Low detoxification capacity in the ileal pouch mucosa of patients with ulcerative colitis. Inflammatory Bowel Diseases 2006; 12(2): 112–126.
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13/12/2021
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Y, A. K., Sk., A. M. S., Konda , R. K., & A, P. (2021). Evaluation of anti-inflammatory activity and anti-oxidant potential of portulaca quadrifida linn. Journal of Innovations in Applied Pharmaceutical Science (JIAPS), 6(3), 58-65. https://doi.org/10.37022/jiaps.v6i3.255
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