CHRONOPHARMACOLOGY AND PERSONALIZED MEDICINE: CURRENT CONCEPTS AND FUTURE PERSPECTIVES

Hemanth Mandla

Mandla Hemanth Priyadarshini Institute of Pharmaceutical Education and Research, 5th Mile, Pulladigunta, Guntur-522017, Andhra Pradesh, India.

Abstract

Chrono pharmacology is a field studying the interaction between biological rhythms, like the circadian rhythm, and the pharmacokinetics (drug absorption, distribution, metabolism, and excretion) and pharmacodynamics (how drugs affect the body) of medications. It emphasizes aligning medicine administration with the body's natural cycles to ameliorate remedial issues and reduce side effects. Circadian rhythms influence drug behaviour and impact systems like the immune, cardiovascular, and nervous systems, affecting drug effectiveness. For example, antihypertensive medications may work better when taken at night, and chemotherapy may be more effective when timed with tumour cell growth cycles. Antidiabetic medicines also show better results when aligned with insulin production. Chrono pharmacology aims to optimize drug treatment by considering the timing of administration, enhancing benefits while minimizing side effects. This approach, known as chronotherapy, is gaining interest in personalized medicine, which tailors treatment plans to individual circadian rhythms, age, and lifestyle. Though promising, chrono pharmacology is still developing. further exploration is required to understand its mechanisms and upgrade clinical guidelines for precise medicine timing, with the eventuality to revise treatment and give safer, more effective curatives.

Keywords: Biological Rhythm, Chrono Pharmacology, Chrono Pharmacokinetics, Chrono Pharmacodynamics, Chrono therapeutics, herapeutic Drug Monitoring

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