AN OVERVIEW OF BUCCAL DRUG DELIVERY SYSTEMS IN MODERN THERAPEUTICS
Abstract
Buccal Drug Delivery System (BDDS) has emerged as an effective alternative to conventional oral drug administration, particularly for drugs undergoing extensive first-pass metabolism and gastrointestinal degradation. Buccal delivery involves the administration of drugs through the buccal mucosa lining the inner cheek, enabling direct entry into systemic circulation. This route enhances bioavailability, reduces dose requirements, and provides rapid onset of action. The buccal mucosa is highly vascularized and easily accessible, making it suitable for both local and systemic drug delivery. BDDS utilizes bioadhesive polymers to prolong residence time at the site of absorption, thereby improving drug permeability and therapeutic efficacy.
Keywords:
Buccal Drug Delivery System (BDDS), Buccal Mucosa, Bioavailability, First-Pass Metabolism, Mucoadhesive Polymers, Permeation Enhancers
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2. Gindi S, Methra T, Chandu BR, et al. Antiurolithiatic and in vitro antioxidant activity of leaves of Ageratum conyzoides in rats. World J Pharm Pharm Sci. 2013;2(2):636-649.
3. Nama S, Chandu BR, Awen BZ, Khagga M. Development and validation of a new RP-HPLC method for the determination of aprepitant in solid dosage forms. Trop J Pharm Res. 2011;10(4):489-494.
4. Kiranmai M, Renuka P, Brahmaiah B, Chandu BR. Vitamin D as a promising anticancer agent. Int J Res Pharm Chem. 2012;2(1):108-112.
5. Degapati RT. Novel approaches in transdermal drug delivery system. World J Pharm Res. 2025;20-25.
6. Dara SR. An overview of the use of natural indicators in acid-base titrations. UPI J Pharm Med Health Sci. 2024:29-35.
7. Srivastava N, Aslam S. Recent advancements and patents on buccal drug delivery systems: a comprehensive review. Recent Pat Nanotechnol. 2022;16(4):308-325.
8. Gibaldi M, Harris D, Robinson JR. The number of drugs administered buccally is increasing. Clin Pharmacol. 1985;3(4).
9. Sharma N, Jain S, Sardana S. Buccoadhesive drug delivery system: a review. J Adv Pharm Educ Res. 2013;3(1):9-12.
10. Squier CA, Wertz PW. Structure and function of the oral mucosa and implications for drug delivery. Drugs Pharm Sci. 1996;74:1-26.
11. Adhikari SN, Nayak BS, Nayak AK, Mohanty B. Formulation and evaluation of buccal patches for delivery of atenolol. AAPS PharmSciTech. 2010;11(3):1038-1044.
12. Wong CF, Yuen KH, Peh KK. Formulation and evaluation of controlled-release Eudragit buccal patches. Int J Pharm. 1999;178(1):11-22.
13. Bhowmik D, Kumar KPS, Deb L. Buccal drug delivery system: a novel drug delivery system. Res J Sci Technol. 2016;8(2):90-100.
Published
05/06/2026
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How to Cite
Kosuri, A. “AN OVERVIEW OF BUCCAL DRUG DELIVERY SYSTEMS IN MODERN THERAPEUTICS”. International Journal of Health Care and Biological Sciences, Vol. 7, no. 2, June 2026, pp. 1-5, https://saapjournals.org/index.php/ijhcbs/article/view/873.
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Review Articles
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