The next generation of Wound Healing: Pioneering Approaches

Sirisha Annavarapu; Venkata Lakshmi G; Vijaya Lakshmi Ch; Babu Rao Chandu

doi:10.46795/ijhcbs.v6i2.687

Annavarapu Sirisha Priyadarshini Institute of Pharmaceutical Education & Research (PIPER) 5th mile, Pulladigunta, Guntur, 522017. Andhra Pradesh, India
G. Venkata Lakshmi Priyadarshini Institute of Pharmaceutical Education & Research (PIPER) 5th mile, Pulladigunta, Guntur, 522017. Andhra Pradesh, India
Ch. Vijaya Lakshmi Priyadarshini Institute of Pharmaceutical Education & Research (PIPER) 5th mile, Pulladigunta, Guntur, 522017. Andhra Pradesh, India
Chandu Babu Rao Priyadarshini Institute of Pharmaceutical Education & Research (PIPER) 5th mile, Pulladigunta, Guntur, 522017. Andhra Pradesh, India

DOI https://doi.org/10.46795/ijhcbs.v6i2.687

Abstract

Wound healing is a complex, multi-phase process involving physical, chemical, and biological mechanisms that restore damaged tissue. When this process is disrupted, it can lead to chronic wounds and abnormal scar formation, which are more susceptible to infection. Acute and chronic wound infections remain a global health concern due to high morbidity, mortality, and the rise of antibiotic-resistant pathogens. Nanomaterials have recently emerged as promising agents in wound healing due to their unique properties, including antimicrobial activity, enhanced tissue regeneration, and controlled drug delivery. These characteristics make them especially effective against biofilm-forming bacteria, which are a major barrier in chronic wound management. Despite their potential, nanomaterial-based therapies face several challenges. Concerns around toxicity, long-term stability, biocompatibility, and scalable production must be addressed. Further research is needed to better understand how these materials interact with biological systems and to ensure safety through rigorous preclinical and clinical testing. Recent advancements in wound care extend beyond nanotechnology, incorporating stem cell therapy, bioengineered skin grafts, and 3D bioprinting to promote skin regeneration and improve healing outcomes. These innovative strategies aim to minimize side effects while enhancing therapeutic effectiveness. In summary, nanomaterials offer exciting possibilities for revolutionizing wound care. However, their clinical translation will require a careful balance between innovation, safety, and regulatory approval. Continued interdisciplinary research is essential to fully realize their potential in managing both acute and chronic wounds.

Keywords: Nano medicine, Wound healing, Dressing for infectious control

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