Concise Summary: Hemochromatosis Along with Its Cure
Abstract
A condition known as hemochromatosis results in excessive iron deposition, which damages several organs. Hemochromatosis affects the liver, pancreas, heart, thyroid, joints, skin, gonads, and pituitary among other organs.Famous diagnostician and teacher Dr. Armand Trosseau published the first medical description of a patient with hemochromatosis in a French pathology paper in 1865.Hemochromatosis is a well-defined illness that can be brought on by mutations in any gene that restricts iron entry into the blood. It is typified by normal iron-driven erythropoiesis and hazardous iron accumulation in parenchymal cells of essential organs. When Feder et al. found in 1996 that a mutation in HFE caused hereditary hemochromatosis, it was a significant discovery for the field of hemochromatosis research.Systemic iron excess of hereditary origin resulting from a hepcidin deficiency, including reduced hepcidin-ferroportin binding activity or production, is known as hemochromatosis. A correct diagnosis of this illness is frequently challenging due to the wide range, lack of specificity, and vagueness of its signs and symptoms. The early warning signs and symptoms include arthralgia, weakness, weight loss, and stomach pain.In this review study, we discuss the pathophysiology, epidemiology, symptoms, and aetiology of hemochromatosis.
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