A review on plasma therapy in covid-19 management and vital role of plasma donation
Abstract
This article is focused mainly onconvalescent plasma therapy in COVID-19 management, its mechanism of neutralizing antibodies, steps of therapy along with the dosage, advantages, disadvantages and cautions. The extent and results of the investigational plasma therapy in India also has been mentioned. This article has a view on the importance, use, steps and vital role of plasma donation. Recently plasma therapy has been used as an investigational therapy in COVID-19 management due to lack of proper treatment or vaccine. Plasma is the liquid component of blood that transports cells, proteins, hormones, vitamins all over the body. Plasma helps support our immune system as it contains antibodies that defend foreign organisms. This is why plasma donations are so incredibly important. Several plasma banks have been set across the country. Plasma therapy is an immediate promising treatment option in the COVID-19 management. But however, it is only used for research and trial purposes until an ICMR study on it efficacy is completed.
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References
2. Covalescent plasma therapy
https://covidindia.org/
3. .Li F. Structure, function, and evolution of coronavirus spike proteins. Annu Rev Virol. 2016;3(1):237–261. [PMC free article] [PubMed] [Google Scholar] [Ref list]
4. .Guangyu Z., Zhao Q. Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. Int J Biol Sci. 2020;16(10):1718–1723. doi: 10.7150/ijbs.45123. [PMC free article] [PubMed] [CrossRef] [Google Scholar] [Ref list]
5. Wan Y., Shang J., Graham R., Baric R.S., Li F. Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS. J Virol. 2020 doi: 10.1128/JVI.00127-20. [Epub ahead of print] [PMC free article] [PubMed] [CrossRef] [Google Scholar] [Ref list]
6. Florescu D.F., Kalil A.C., Hewlett A.L. Administration of brincidofovir and convalescent plasma in a patient with Ebola virus disease. Clin Infect Dis. 2015;61(6):969–973. [PubMed] [Google Scholar] [Ref list]
7. https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.hematology.org/covid-19/covid-19-and-convalescent-plasma&ved=2ahUKEwibuMr-hu3qAhUPSX0KHeA7D5kQFjAJegQIBxAB&usg=AOvVaw19rX91SmSSwTZI8foDxlpE&cshid=1595840512428.
8. Convalescent plasma: A possible treatment protocol for COVID- 19 patients suffering from diabetes or underlying liver diseases
AshishYashwantraoPawar, ApoorvaPrashantHiray, [...], and Yogesh Suresh Ahire
9. Use of plasma therapy successful, claims Pune hospital - https://health.economictimes.indiatimes.com/news/hospitals/use-of-plasma-therapy-successful-claims-pune-hospital/75881548
10. Coronavirus outbreak -Author AbigaliBanerji
https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.firstpost.com/health/coronavirus-outbreak-what-is-plasma-therapy-is-it-the-miracle-cure-the-world-has-been-waiting-for-8254311.html/amp&ved=2ahUKEwif98eSne3qAhUN63MBHaSODD4QFjAFegQIBRAB&usg=AOvVaw0KDvFOVaYzGWXKDFeygk1V&cf=1&cshid=1595846034170
11. Plasma therapy not approved treatment for Covid-19, can be dangerous, says Centre - india news - Hindustan Times - https://www.hindustantimes.com/india-news/plasma-therapy-not-approved-treatment-for-covid-19-can-be-dangerous-says-centre/story-vTeSdM43Q7ND3lUiThCAZK.html.
12. https://www.donatingplasma.org/why
13. Recommendations for Investigational COVID‐19 Convalescent Plasma | FDA [Internet]. https://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/recommendations-investigational-covid-19-convalescent-plasma. Accessed May 14, 2020
14. BiotestPlasmaCenter. PlasmaDonationEligibility.Accessed at biotestplasma.com/donation-process/donation-eligibility.
15. Saving Lives Through Plasma Donation.BY RONALE TUCKER RHODES,MS.

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