Review article on in-situ of ocular drug delivery system

Eswari Samaikya Reddy G; Durga srinivasarao M; Venkatesh P

doi:10.46795/ijhcbs.v3i1.265

G. Eswari Samaikya Reddy B.Pharmacy final year student, Jagan’s Institute of Pharmaceutical Sciences ,Nellore
M. Durga srinivasarao Associate Professor, Dept.of Pharmaceutics, Jagan’s Institute of Pharmaceutical Science, Nellore
P. Venkatesh Principal, Jagan’s Institute of Pharmaceutical Science, Nellore

DOI https://doi.org/10.46795/ijhcbs.v3i1.265

Abstract

Ocular drug delivery is the most challenging and interesting field in the pharmaceutical industry and pharmaceutical scientist. Blindness and vision impairment are the most problematic global health problem. In ophthalmic in-situ gels, various polymers are used. Generally, hydrogels are used. These polymers will increase the viscosity of the solution. In the physiology of the eye, this organ is impermeable to foreign particles. Novel drug delivery systems focus to overcome the biological barrier which can obstruct efficient ocular drug delivery. The conventional ophthalmic formulation shows a short pre-corneal residence time and poor bioavailability. Many attempts have been made towards the development of stable sustained-release in-situ gels. In this review, we specify a brief note about in-situ gels, various approaches for in-situ gelling systems, different types of polymers used in in-situ gels, their mechanisms of gel formation, and evaluation of polymeric in-situ gel.

Keywords: Ocular drug delivery, In-situ gels, cul-de-sac, pH-induced in-situ gel system

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