Homeopathy in chronic disease management: a critical review of the evidence

Rani Sharkar Tithy; Gaffar Miah Abdul

doi:10.46797/ijacm.v6i2.777

Tithy Rani Sharkar Department of Materia Medica, NatoreHomeo Medical College, Natore, Bangladesh
Abdul Gaffar Miah Department of Genetics and Animal Breeding, Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh

DOI https://doi.org/10.46797/ijacm.v6i2.777

Abstract

Homeopathy remains one of the most widely practiced complementary and alternative medicine (CAM) modalities worldwide, particularly among individuals with chronic non-communicable diseases (NCDs) who seek safe, holistic, and personalized therapeutic options. Despite its global popularity, controversy continues regarding its mechanisms of action and clinical effectiveness. This review critically evaluates the current evidence on the role of homeopathy in chronic disease management. A comprehensive review of randomized controlled trials (RCTs), systematic reviews, and meta-analyses published between 2000 and 2025 was conducted. Studies were included if they examined homeopathic interventions in chronic conditions such as asthma, arthritis, type 2 diabetes mellitus, depression, chronic pain, and fibromyalgia. Data were synthesized thematically to assess efficacy, mechanistic plausibility, methodological quality, and safety outcomes. Mechanistic hypotheses suggest that hormesis, nanoparticle-mediated signaling, immune modulation, and neuropsychological or psychosocial mechanisms may contribute to the therapeutic effects of homeopathy. Meta-analytic evidence demonstrates modest but statistically significant improvements in subjective measures such as pain, fatigue, and quality of life across several chronic diseases, with standardized mean differences ranging from 0.18 to 0.25. However, objective clinical outcomes, including spirometry and HbA1c, rarely show consistent benefit. Methodological challenges, including small sample sizes, heterogeneous interventions, limited follow-up durations, and a high risk of bias, continue to constrain the reliability of existing findings. Importantly, homeopathy exhibits a favorable safety profile, with no serious adverse events reported across chronic disease studies. Current evidence indicates that homeopathy may provide modest adjunctive benefits for symptom relief and improved patient satisfaction among individuals with chronic illnesses, although its specific therapeutic mechanisms remain uncertain. Integration of homeopathy into evidence-based, patient-centered chronic disease management frameworks may enhance holistic care. Future research should emphasize large-scale, multicenter randomized trials with standardized outcome measures and mechanistic endpoints to better define clinical relevance and biological plausibility.

Keywords: Homeopathy, Chronic disease management, Complementary and alternative medicine, Meta-analysis, Immunomodulation

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