HYPERBARIC OXYGEN THERAPY AS A COMPLEMENTARY OR ALTERNATIVE THERAPY FOR CHRONIC ORAL AND GASTROINTESTINAL DISORDERS: A NARRATIVE REVIEW
Abstract
Failure of traditional conservative pharmacological agents in the treatment of chronic oral and gastrointestinal tract disorders (GITD) increased the use of complementary and alternative therapies (CAT) to make use of the strong anti-fibrotic and anti-inflammatory effects of CAT. The purpose of this review is to focus on the role of hyperbaric oxygen therapy (HBOT) in the treatment of chronic oral and GIITD. Being one of CAT, HBOT can be utilized as a main and/or an adjunctive therapeutic modality in the treatment of GITD. In addition to anti-fibrotic and anti-inflammatory effects induced by CAT, HBOT adds more great benefits as neovascularization increase, bacterial growth inhibition, promotion of intestinal mucosal healing, enhancement of delayed gastric emptying in dyspeptic patients, increase of the intestinal motility, and hypoxia improvement by supplying more oxygen especially for fibrosed and/or radiation-induced tissue injuries. Awareness of HBOT – as a complementary treatment for chronic oral and GITDS – is highly needed to develop more future research in this field.
Keywords:
Hyperbaric oxygen therapy, complementary and alternative therapy, oral cavity, gastrointestinal diseases
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References
1. Haas L, Mcclain C, Varilek G. Complementary and alternative medicine and gastrointestinal diseases. Curr Opin Gastroenterol 2000;16:188-196.
2. Liptak GS. Complementary and alternative therapies for cerebral palsy. Ment Retard Dev Disabil Res Rev 2005;11:156-163.
3. Chiarioni G, Pesce M, Fantin A, Sarnelli G. Complementary and alternative treatment in functional dyspepsia. United European Gastroenterol J 2018;6:5-12.
4. Ahmad FM, Sankhla CS. Hyperbaric oxygen therapy in neurological diseases. Neurol India 2019; 67:655.
5. El Oumri AA, Badi H, Khaloufi S. Hyperbaric oxygen therapy: Focus. Open J Emerg Med 2018;6:15-20.
6. Henrykowska G, Buczyński A, Lewicka M, Zawadzka M. The Knowledge of a selected group of medical students on hyperbaric oxygen therapy. Pol Hyperb Res 2018;62:75-83.
7. Sytsma TT, Haller EP, Youdas JW, Krause DA, Hellyer NJ, Pawlina W, et al. Long‐term effect of a short interprofessional education interaction between medical and physical therapy students. Anat Sci Edu 2015;8:317-323.
8. Löndahl M, Boulton AJ. Hyperbaric oxygen therapy: Useless or useful? A battle. Diabetes Metab Res Rev 2020;e3233.
9. Jeter JP, Wong EB. Hyperbaric oxygen therapy in dermatology. Cutis 2020;105:24-27.
10. Kirby JP, Snyder J, Schuerer DJ, Peters JS, Bochicchio GV. Essentials of hyperbaric oxygen therapy: 2019 review. Missouri Med 2019;116:176.
11. Wandawa G, Mustaqimah DN, Sidik S, Saraswati H, Putri FA, Auerkari EI. Efficacy of hyperbaric oxygen therapy as an adjunctive therapy of chronic periodontitis. J Int Dent Med Res 2017;10:72.
12. Mcmillan G, Glover M. The clinical and economic potential of hyperbaric oxygen therapy in the treatment of diabetic ulceration and other conditions. Int J Low Extrem Wounds 2007;6:130-138.
13. Koo JH, Song SH, Oh HS, Oh SH. Comparison of the short-term effects of hyperbaric oxygen therapy and complex decongestive therapy on breast cancer-related lymphedema: A pilot study. Med J 2020;99:e19564.
14. Hexdall E, Brave R, Kraft K, Siewers J. Diving deep into hyperbaric oxygen therapy. Nurs J 2019;46:28-36.
15. Kumar MA, Radhika B, Gollamudi N, Reddy SP, Yaga US. Hyperbaric oxygen therapy—a novel treatment modality in oral submucous fibrosis: a review. J Clin Diagn Res 2015;9.
16. Eve DJ, Steele MR, Sanberg PR, Borlongan CV. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Treat 2016;12:2689.
17. Shih YH, Wang TH, Shieh TM, Tseng YH. Oral submucous fibrosis: a review on etiopathogenesis, diagnosis, and therapy. Int J Mol Sci 2019;20:2940.
18. Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, et al. Upregulation of HIF‐1α in malignant transformation of oral submucous fibrosis. J Oral Path Med 2008;37:372-377.
19. Arakeri G, Rai KK, Boraks G, Patil SG, ALjabab AS, Merkx MAW et al. Current protocols in the management of oral submucous fibrosis: an update. J Oral Path Med 2017;46:418-423.
20. Tyagi H, Lakhanpal M, Dhillon M, Baduni A, Goel A, Banga A. Efficacy of therapeutic ultrasound with soft tissue mobilization in patients of oral submucous fibrosis. JIAOMR 2018;30:349.
21. ARORA A. Treatment modalities in oral submucous fibrosis: a review. J Adv Med Dent Sci Res 2019;7:11-15.
22. Sharma M, Radhakrishnan R. Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies. J Oral Path Med 2017;46:424-430.
23. Hadley T, Song C, Wells L, Lehnhardt J, Rogers MW, Anderson J, et al. Does hyperbaric oxygen therapy have the potential to improve salivary gland function in irradiated head and neck cancer patients?. Med Gas Res 2013;3:15.
24. Ismail AMA, EZZ EL-din HM, Abdelaal MEM. Impact of transcutaneous electrical nerve stimulation (TENS) on hyposalivation in type 2 diabetics. Biosci Res 2019;16: 690-694.
25. Lovelace TL, Fox NF, Sood AJ, Nguyen SA, Day TA. Management of radiotherapy-induced salivary hypofunction and consequent xerostomia in patients with oral or head and neck cancer: meta-analysis and literature review. Oral Surg Oral Med Oral Path Oral Radiol 2014;117:595-607.
26. Meng L, Liu J, Peng B, Fan M, Nie M, Chen Z, et al. The persistence of Streptococcus mutans in nasopharyngeal carcinoma patients after radiotherapy. Caries Res 2005;39:484–9.
27. Uslu GH, Çebi G, Çobanoğlu B. Hyperbaric oxygen therapy in the treatment of complications of irradiation in laryngeal cancer. Contemp Oncol 2018;22:202.
28. Sønstevold T, Johannessen AC, Reed RK, Salvesen GS, Stuhr L. Hyperbaric oxygen treatment did not significantly affect radiation injury in the mandibular area of rats. Oral Surg Oral Med Oral Path Oral Radiol 2018;125:112-119.
29. Gerlach NL, Barkhuysen R, Kaanders JHAM, Janssens GORJ, Sterk W, Merkx MAW. The effect of hyperbaric oxygen therapy on quality of life in oral and oropharyngeal cancer patients treated with radiotherapy. Int J Oral Max Surg 2008;37:255-259.
30. Al Habashneh R, Mashal MA, Khader Y, Qudah R. Clinical and biological effects of adjunctive photodynamic therapy in refractory periodontitis. Lasers Med Sci 2019;10:139.
31. Robo I, Heta S, Karkanaqe L, Ostreni V. HBOT application at cases of gingival inflammation. J Dent Oral Sci 2019;1:1-16.
32. Badr DE, Alenazi MH, Alowein MA, Alodhay MM, Alahaideb MM, Alamri AA, et al. Association between diabetes and periodontal disease: a literature review. EC Dent Sci 2019;18:2467-2474.
33. Mulawarmanti D, Parisihni K. The Effect of sticopus hermanii-hyperbaric oxygen therapy to inflammatory response of diabetic periodontitis. IOP Conf Ser Earth Environ Sci 2019;217:012060.
34. Liao J, Wu MJ, Mu YD, Li P, Go J. Impact of hyperbaric oxygen on tissue healing around dental implants in beagles. Med Sci Mon Int Med J Exp Clin Res 2018;24:8150.
35. Oh JH, Kwon JG, Jung HK, Tae CH, Song KH, Kang SJ, et al., Clinical practice guidelines for functional dyspepsia in Korea. J Neurogastroenterol Motil 2020;26:29.
36. Dong Y, Xing L, Zhu A. Observation of Gengjian decoction combined with hyperbaric oxygen therapy on functional dyspepsia during perimenopausal period. Hebei J Trad Chin Med 2012;1:46.
37. Masuda A, Nakano T, Uehara H, Kuroki K, Tei C. Hyperbaric oxygen for anorexia nervosa. Int Med 2001;40:635-637.
38. Eckert KG, Abbasi-Neureither I, Köppel M, Huber G. Structured physical activity interventions as a complementary therapy for patients with inflammatory bowel disease–a scoping review and practical implications. BMC Gastroenterol 2019;19:115.
39. Duff W, Haskey N, Potter G, Alcorn J, Hunter P, Fowler S. Non-pharmacological therapies for inflammatory bowel disease: Recommendations for self-care and physician guidance. World J Gastroenterol 2018;24:3055.
40. Rossignol DA. Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis. Med Gas Res 2012;2:6.
41. Dulai PS, Gleeson MW, Taylor D, Holubar SD, Buckey JC, Siegel CA. Systematic review: The safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease. Aliment Pharm Ther 2014,39:1266-1275.
42. Bekheit M, Baddour N, Katri K, Taher Y, El Tobgy K, Mousa E. Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series, BMJ Open Gastroenterol 2016;3:e000082.
43. Antonucci A, Fronzoni L, Cogliandro L, Cogliandro RF, Caputo C, De Giorgio R, et al. Chronic intestinal pseudo-obstruction. World J Gastroenterol 2008;14:2953.
44. De Giorgio R, Sarnelli G, Corinaldesi R, Stanghellini V. Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction. Gut 2004;53:1549-1552.
45. Yokota T, Suda T, Tsukioka S, Takahashi T, Honma T, Seki K, et al. The striking effect of hyperbaric oxygenation therapy in the management of chronic idiopathic intestinal pseudo-obstruction. Am J Gastroenterol 2000;95:285-288.
46. Di Pietropaolo M, Trinci M, Giangregorio C, Galluzzo M, Miele V. Pneumatosis cystoides intestinalis: case report and review of literature. Clin J Gastroenterol 2020;13:31-36.
47. Umapathi BA, Friel CM, Stukenborg GJ, Hedrick TL. Estimating the risk of bowel ischemia requiring surgery in patients with tomographic evidence of pneumatosis intestinalis. Am J Surg 2016;212:762-768.
48. Feuerstein JD, White N, Berzin TM. Pneumatosis intestinalis with a focus on hyperbaric oxygen therapy. Mayo Clin Proc 2014;89:697-703.
49. Singh G, Sharma D, Rathi A, Singh K. Curcumin for radiation induced enteritis: A review article. Int J Med Paediatr Oncol 2017;3:1-2.
50. Yuan JH, Song LM, Liu Y, Li MW, Lin Q, Wang R, et al. The Effects of hyperbaric oxygen therapy on pelvic radiation induced gastrointestinal complications (rectal bleeding, diarrhea, and pain): a meta-analysis. Front Oncol 2020;10:390.
2. Liptak GS. Complementary and alternative therapies for cerebral palsy. Ment Retard Dev Disabil Res Rev 2005;11:156-163.
3. Chiarioni G, Pesce M, Fantin A, Sarnelli G. Complementary and alternative treatment in functional dyspepsia. United European Gastroenterol J 2018;6:5-12.
4. Ahmad FM, Sankhla CS. Hyperbaric oxygen therapy in neurological diseases. Neurol India 2019; 67:655.
5. El Oumri AA, Badi H, Khaloufi S. Hyperbaric oxygen therapy: Focus. Open J Emerg Med 2018;6:15-20.
6. Henrykowska G, Buczyński A, Lewicka M, Zawadzka M. The Knowledge of a selected group of medical students on hyperbaric oxygen therapy. Pol Hyperb Res 2018;62:75-83.
7. Sytsma TT, Haller EP, Youdas JW, Krause DA, Hellyer NJ, Pawlina W, et al. Long‐term effect of a short interprofessional education interaction between medical and physical therapy students. Anat Sci Edu 2015;8:317-323.
8. Löndahl M, Boulton AJ. Hyperbaric oxygen therapy: Useless or useful? A battle. Diabetes Metab Res Rev 2020;e3233.
9. Jeter JP, Wong EB. Hyperbaric oxygen therapy in dermatology. Cutis 2020;105:24-27.
10. Kirby JP, Snyder J, Schuerer DJ, Peters JS, Bochicchio GV. Essentials of hyperbaric oxygen therapy: 2019 review. Missouri Med 2019;116:176.
11. Wandawa G, Mustaqimah DN, Sidik S, Saraswati H, Putri FA, Auerkari EI. Efficacy of hyperbaric oxygen therapy as an adjunctive therapy of chronic periodontitis. J Int Dent Med Res 2017;10:72.
12. Mcmillan G, Glover M. The clinical and economic potential of hyperbaric oxygen therapy in the treatment of diabetic ulceration and other conditions. Int J Low Extrem Wounds 2007;6:130-138.
13. Koo JH, Song SH, Oh HS, Oh SH. Comparison of the short-term effects of hyperbaric oxygen therapy and complex decongestive therapy on breast cancer-related lymphedema: A pilot study. Med J 2020;99:e19564.
14. Hexdall E, Brave R, Kraft K, Siewers J. Diving deep into hyperbaric oxygen therapy. Nurs J 2019;46:28-36.
15. Kumar MA, Radhika B, Gollamudi N, Reddy SP, Yaga US. Hyperbaric oxygen therapy—a novel treatment modality in oral submucous fibrosis: a review. J Clin Diagn Res 2015;9.
16. Eve DJ, Steele MR, Sanberg PR, Borlongan CV. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Treat 2016;12:2689.
17. Shih YH, Wang TH, Shieh TM, Tseng YH. Oral submucous fibrosis: a review on etiopathogenesis, diagnosis, and therapy. Int J Mol Sci 2019;20:2940.
18. Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, et al. Upregulation of HIF‐1α in malignant transformation of oral submucous fibrosis. J Oral Path Med 2008;37:372-377.
19. Arakeri G, Rai KK, Boraks G, Patil SG, ALjabab AS, Merkx MAW et al. Current protocols in the management of oral submucous fibrosis: an update. J Oral Path Med 2017;46:418-423.
20. Tyagi H, Lakhanpal M, Dhillon M, Baduni A, Goel A, Banga A. Efficacy of therapeutic ultrasound with soft tissue mobilization in patients of oral submucous fibrosis. JIAOMR 2018;30:349.
21. ARORA A. Treatment modalities in oral submucous fibrosis: a review. J Adv Med Dent Sci Res 2019;7:11-15.
22. Sharma M, Radhakrishnan R. Limited mouth opening in oral submucous fibrosis: reasons, ramifications, and remedies. J Oral Path Med 2017;46:424-430.
23. Hadley T, Song C, Wells L, Lehnhardt J, Rogers MW, Anderson J, et al. Does hyperbaric oxygen therapy have the potential to improve salivary gland function in irradiated head and neck cancer patients?. Med Gas Res 2013;3:15.
24. Ismail AMA, EZZ EL-din HM, Abdelaal MEM. Impact of transcutaneous electrical nerve stimulation (TENS) on hyposalivation in type 2 diabetics. Biosci Res 2019;16: 690-694.
25. Lovelace TL, Fox NF, Sood AJ, Nguyen SA, Day TA. Management of radiotherapy-induced salivary hypofunction and consequent xerostomia in patients with oral or head and neck cancer: meta-analysis and literature review. Oral Surg Oral Med Oral Path Oral Radiol 2014;117:595-607.
26. Meng L, Liu J, Peng B, Fan M, Nie M, Chen Z, et al. The persistence of Streptococcus mutans in nasopharyngeal carcinoma patients after radiotherapy. Caries Res 2005;39:484–9.
27. Uslu GH, Çebi G, Çobanoğlu B. Hyperbaric oxygen therapy in the treatment of complications of irradiation in laryngeal cancer. Contemp Oncol 2018;22:202.
28. Sønstevold T, Johannessen AC, Reed RK, Salvesen GS, Stuhr L. Hyperbaric oxygen treatment did not significantly affect radiation injury in the mandibular area of rats. Oral Surg Oral Med Oral Path Oral Radiol 2018;125:112-119.
29. Gerlach NL, Barkhuysen R, Kaanders JHAM, Janssens GORJ, Sterk W, Merkx MAW. The effect of hyperbaric oxygen therapy on quality of life in oral and oropharyngeal cancer patients treated with radiotherapy. Int J Oral Max Surg 2008;37:255-259.
30. Al Habashneh R, Mashal MA, Khader Y, Qudah R. Clinical and biological effects of adjunctive photodynamic therapy in refractory periodontitis. Lasers Med Sci 2019;10:139.
31. Robo I, Heta S, Karkanaqe L, Ostreni V. HBOT application at cases of gingival inflammation. J Dent Oral Sci 2019;1:1-16.
32. Badr DE, Alenazi MH, Alowein MA, Alodhay MM, Alahaideb MM, Alamri AA, et al. Association between diabetes and periodontal disease: a literature review. EC Dent Sci 2019;18:2467-2474.
33. Mulawarmanti D, Parisihni K. The Effect of sticopus hermanii-hyperbaric oxygen therapy to inflammatory response of diabetic periodontitis. IOP Conf Ser Earth Environ Sci 2019;217:012060.
34. Liao J, Wu MJ, Mu YD, Li P, Go J. Impact of hyperbaric oxygen on tissue healing around dental implants in beagles. Med Sci Mon Int Med J Exp Clin Res 2018;24:8150.
35. Oh JH, Kwon JG, Jung HK, Tae CH, Song KH, Kang SJ, et al., Clinical practice guidelines for functional dyspepsia in Korea. J Neurogastroenterol Motil 2020;26:29.
36. Dong Y, Xing L, Zhu A. Observation of Gengjian decoction combined with hyperbaric oxygen therapy on functional dyspepsia during perimenopausal period. Hebei J Trad Chin Med 2012;1:46.
37. Masuda A, Nakano T, Uehara H, Kuroki K, Tei C. Hyperbaric oxygen for anorexia nervosa. Int Med 2001;40:635-637.
38. Eckert KG, Abbasi-Neureither I, Köppel M, Huber G. Structured physical activity interventions as a complementary therapy for patients with inflammatory bowel disease–a scoping review and practical implications. BMC Gastroenterol 2019;19:115.
39. Duff W, Haskey N, Potter G, Alcorn J, Hunter P, Fowler S. Non-pharmacological therapies for inflammatory bowel disease: Recommendations for self-care and physician guidance. World J Gastroenterol 2018;24:3055.
40. Rossignol DA. Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis. Med Gas Res 2012;2:6.
41. Dulai PS, Gleeson MW, Taylor D, Holubar SD, Buckey JC, Siegel CA. Systematic review: The safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease. Aliment Pharm Ther 2014,39:1266-1275.
42. Bekheit M, Baddour N, Katri K, Taher Y, El Tobgy K, Mousa E. Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series, BMJ Open Gastroenterol 2016;3:e000082.
43. Antonucci A, Fronzoni L, Cogliandro L, Cogliandro RF, Caputo C, De Giorgio R, et al. Chronic intestinal pseudo-obstruction. World J Gastroenterol 2008;14:2953.
44. De Giorgio R, Sarnelli G, Corinaldesi R, Stanghellini V. Advances in our understanding of the pathology of chronic intestinal pseudo-obstruction. Gut 2004;53:1549-1552.
45. Yokota T, Suda T, Tsukioka S, Takahashi T, Honma T, Seki K, et al. The striking effect of hyperbaric oxygenation therapy in the management of chronic idiopathic intestinal pseudo-obstruction. Am J Gastroenterol 2000;95:285-288.
46. Di Pietropaolo M, Trinci M, Giangregorio C, Galluzzo M, Miele V. Pneumatosis cystoides intestinalis: case report and review of literature. Clin J Gastroenterol 2020;13:31-36.
47. Umapathi BA, Friel CM, Stukenborg GJ, Hedrick TL. Estimating the risk of bowel ischemia requiring surgery in patients with tomographic evidence of pneumatosis intestinalis. Am J Surg 2016;212:762-768.
48. Feuerstein JD, White N, Berzin TM. Pneumatosis intestinalis with a focus on hyperbaric oxygen therapy. Mayo Clin Proc 2014;89:697-703.
49. Singh G, Sharma D, Rathi A, Singh K. Curcumin for radiation induced enteritis: A review article. Int J Med Paediatr Oncol 2017;3:1-2.
50. Yuan JH, Song LM, Liu Y, Li MW, Lin Q, Wang R, et al. The Effects of hyperbaric oxygen therapy on pelvic radiation induced gastrointestinal complications (rectal bleeding, diarrhea, and pain): a meta-analysis. Front Oncol 2020;10:390.
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04/12/2020
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Ismail, A. “HYPERBARIC OXYGEN THERAPY AS A COMPLEMENTARY OR ALTERNATIVE THERAPY FOR CHRONIC ORAL AND GASTROINTESTINAL DISORDERS: A NARRATIVE REVIEW”. International Journal of Alternative and Complementary Medicine, Dec. 2020, pp. 33-40, https://saapjournals.org/index.php/ijacm/article/view/114.
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