FORMULATION AND EVALUATION OF GANCICLOVIR PROLIPOSOMAL GEL FOR TRANSDERMAL DRUG DELIVERY SYSTEM

Beedha Saraswathi; Ravi Kumar Konda; Krishnaveni L; Nagavalli G; Mounika B

doi:10.46956/ijihd.v11i1.858

Beedha Saraswathi Department of Pharmaceutics, Hetero institute of Pharmaceutical Sciences, B Gangaram, Telangana -507 303.
Konda Ravi Kumar Department of Pharmaceutical Chemistry, Hetero institute of Pharmaceutical Sciences, B Gangaram, Telangana -507 303.
L.Krishnaveni Department of Pharmacology, Hetero institute of Pharmaceutical Sciences, B Gangaram, Telangana -507 303.
G.Nagavalli Department of Pharmaceutical Analysis, Hetero institute of Pharmaceutical Sciences, B Gangaram, Telangana -507 303.
B.Mounika Department of Pharmaceutics, Hetero institute of Pharmaceutical Sciences, B Gangaram, Telangana -507 303.

DOI https://doi.org/10.46956/ijihd.v11i1.858

Abstract

Proliposomes are free flowing powder formulations containing water soluble carrier particles coated with phospholipids that immediately form a liposomal dispersion on contact with water in the body. The resulting liposomes may act as a sustained release dosage form of the loaded drugs. Proliposomes are composed of drug, phospholipid and a water soluble porous powder and can be stored sterilized in a dried state. Because of the solid properties, the stability problems of liposome can be resolved without influencing their intrinsic characteristics. Improvement of Solubility and bioavailability of poorly water soluble drugs.In the present work an attempt was being made to formulate and evaluate ganciclovir proliposomal gel for topical delivery for the treatment of viral infections. Phosphatidyl choline, Cholesterol and mannitol were used as excipients in the preparation of proliposomes. The drug and excipient compatibility was studied by using FTIR. The prepared proliposomes were tested for drug release F2 formulation shown maximum drug release which is considered as the optimized formulation. Gel formulation was prepared by taking different quantities of gellan gum. To the prepared gel formulations the optimized proliposomes were incorporated and then diffusion studies were conducted to the gel formulations to know the in vitro drug release. Formulation F2 shown maximum drug release hence it was considered as optimized formulation.

Keywords: Ganciclovir, Proliposomal gel, Proliposomes, Liposomes, Excipients, liposomal dispersion

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