Development and evaluation of matrix type transdermal patches of Simvastatin

Aftaab; Kapil Kumar; Vaishali Chauhan; Ikram; Vaishali Rajput

doi:10.46956/ijihd.v8i5.489

Aftaab Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand.
Kapil Kumar Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.
Vaishali Chauhan Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.
Ikram Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India
Vaishali Rajput Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.

DOI https://doi.org/10.46956/ijihd.v8i5.489

Abstract

Transdermal patches are a cutting-edge drug delivery technology, as it avoids first-pass metabolism results in increased bioavailability and aid in the delivery of drug molecules into the systemic circulation at predetermined and controlled rate.

Aim behind this invention was to formulate a stable, reproducible and non-infringing & examine matrix-type transdermal patches of Simvastatin by using solvent evaporation method and the formulation consist various polymer including HPMC, Ethyl Cellulose, Chitosan, PVPK-30 and Eudragit RS 100, plasticizers like glycerine, propylene glycol, and trietholamine are utilised, along with solvents like octanol and ethanol. The prepared patches are assessed for thickness, weight variation, folding endurance, moisture content, drug content, surface pH and in vitro diffusion studies.

The results indicated that the formulation P4 showed better characteristic properties and in vitro drug diffusion.

Keywords: Transdermal drug delivery system, Simvastatin, HPMC, Eudragit RS100, Ethyl Cellulose.

Keywords: Transdermal drug delivery system, Simvastatin, HPMC, Eudragit RS100, Ethyl Cellulose

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Author Biographies

Aftaab, Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand.

Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand.

Kapil Kumar, Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.

Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.

Vaishali Chauhan, Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.

Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.

Ikram, Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India

Vaishali Rajput, Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.

Division of Pharmaceutics, Global Institute of Pharmaceutical Education and Research, Kashipur, Uttarakhand, India.

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