Wound healing activity of hydro-alcoholic extract of Ocimum basilicum Linn. aerial parts in wistar rats

Gaurav Dubey Gaurav Dubey; Anupam Kumar Pathak Anupam Kumar Pathak

Gaurav Dubey RKDF School of Pharmaceutical Science Bhopal-462021, MP (India)
Anupam Kumar Pathak Head of Department, Department of Pharmacy, Barkatullah University, Bhopal-462021, MP (India)

Abstract

Objective: The main objective of this investigation was to develop a product, which may give a wound healing property and enhance wound healing process like increase the collagen synthesis, fibroblast proliferation, angiogenesis and epithelialization, because products which are available in market are either antiseptic or antimicrobial. Methods: The hydro-alcoholic extract of aerial parts of Ocimum basilicum Linn. was used to evaluate wound healing activity using excision wound model. In excision wound model, the ointment of hydro-alcoholic extract of aerial parts was applied till complete epithelization occurs and evaluated for various parameters such as wound area measurement; percentage wound contraction and period of epithelization. Results: There was a significant decrease (P<0.01) in the wound area (mm2) in test groups as compared to the control which was measured on 0, 4th, 8th, 12th and 16th post wounding days. The rate of epithelization was a faster in animal of test groups as compared to the control group. Conclusion: It may be concluded that the phytoconstituents present in the hydro-alcoholic extract of aerial parts of Ocimum basilicum Linn are responsible for wound contraction and increased rate of epithelialization.
Keywords: , , ,

Keywords: Wound healing, Excision wound model, Inflammation, Ocimum basilicum Linn

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