Phytocompounds used as excipients in mucoadhesive systems an outline on buccal tablets and films
Abstract
Excipients from natural, semi synthetic, synthetic origin shares the major volumes in any pharmaceutical formulations. Natural derived additives play a multifunctional role in the pharmaceutical dosage forms. These natural excipients can be modified for it functionality to behave in a multifunctional effects which is beneficial to the therapeutic regimen. Excipients from natural sources categorized according to their functionality as disintegrating agent, binders, film forming agents, release modifiers, thickening agents, viscosity enhancers, stabilizers, emulsifiers, suspending agents and mucoadhesives. Mucoadhesives properties from natural polymers are widely explored by researchers in various mucoadhesive systems. In this review a brief concept of mucoadhesive systems of selected class of natural polymers were outlined.
Keywords:
Excipients, Mucoadhesive, Buccal Tablets, Buccal Films, Chitosan, Alginate
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References
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2 Malafaya PB, Silva GA, Reis, RL. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Advanced Drug Delivery Reviews. 2007; 59: 207-233.
3 McChesney JD, Venkataraman SK, Henri JT. Plant natural products: Back to the future or into extinction?. Phytochemistry 2007; 68: 2015-2022.
4 Tausif Alam MD, Nayyar P, Pramod KS. FDA-Approved Natural Polymers for Fast Dissolving Tablets. Journal of Pharmaceutics. 2014; Article ID 952970, 6 pages.
5 Pahuja P, Arora S, Pawar P. Ocular drug delivery system: a reference to natural polymers. Expert Opinion on Drug Delivery. 2012; ;9(7):837-861
6 Kumar SA, Vivek D, Vandana A. Role of natural polymers used in floating drug delivery system. Journal of Pharmaceutical and Scientific Innovation.2012; 1(3):11–15.
7 Roy S, Pal K, Anis A, Pramanik K, Prabhakar B. Polymers in Mucoadhesive Drug-Delivery Systems: A Brief Note. Designed Monomers and Polymers. 2009; 12:483-495.
8 Grabovac V, Guggi D, Bernkop-Schnurch A. Comparison of the mucoadhesive properties of various polymers. Advanced Drug Delivery Reviews. 2005; 57:1713–1723.
9 Mythri G, Kavitha M, Rupesh Kumar Sd, Jagadeesh Singh.Novel Mucoadhesive Polymers –A Review. Journal of Applied Pharmaceutical Science. 2011; 01(08);37-42.
10 Smart JD. The basics and underlying mechanisms of mucoadhesion. Advenced Drug Delivery Reviews. 2005; 57(11):1556-1568.
11 Pranshu Tangri, Satheesh Madav NV. Recent Advances in Oral Mucoadhesive Drug Delivery System: A review. International Jorrnal of Pharma. Research and Development. 2011; 3(2): 151-162.
12 Pramod Y, Munish KD, Kailash P, Krutika S. Mucoadhesive bilayer buccal tablet of carvedilol-loaded chitosan microspheres: in vitro, pharmacokinetic and pharmacodynamics investigations. Journal of Microencapsulation. 2012; 29(2): 126–137.
13 Miyazaki S, Nakayama A, Oda M, Takada M, Attwood D. Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery. Biological and Pharmaceutical Bulletin. 1994;17(5):745-747.
14 Dasharath M P, Pratik M S, Chhagan N P. Formulation and evaluation of bioadhesive buccal drug delivery of repaglinide tablets. 2012; 6(3): 171-179.
15 Gururaj SK, Raghavendra Rao NG, Narasimhareddy D. Formulation development and evaluation of Terbutaline Sulphate mucoahdesive buccal tablets. International Research Journal of Pharmacy. 2013; 4(3):189-192.
16 Saleem MA, Sudhir SP, Shaikh AU, Vishal KS. Development and Evaluation of Mucoadhesive Buccal Tablets of Sumatriptan Succinate using Natural Gums. Research Journal of Pharmacy and Technology. 2011; 4(7): 1140-1146.
17 Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. European Journal of Pharmaceutics and Biopharmaceutics. 2002; 53: 233–239.
18 Raut DB, Sakhare RS, Kankudte AD, Muli PN, Bharkad VB. Formulation and in vitro evaluation of mucoadhesive buccal tablet of losartan potassium using synthetic and natural polymers. World Journal of Pharmaceutical research. 2013; 2(5):1577-1590.
19 Balagani PK, Pallepati K, Katamreddy JD. Formulation design and evaluation of mucoadhesive buccal tablets of nitroglycerin. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6(7):251-259.
20 Varshosaz J, Karimzadeh S. Development of cross linked chitosan films for oral mucosal delivery of lidocaine. Research in Pharmaceutical Sciences. 2007; 2:43-52.
21 Senel S, Ikinci G, Kas S, Yousefi Rad A, Sargon MF, Hincal AA. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. International Journal of Pharmaceutics. 2000; 193(2):197-203
22 Dinesh R, Mohammed M, Boateng JS. Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery. International Journal of Biotechnology. 2010; 3(4): 169-181.
23 Adhikari SN, Nayak BS, Nayak AK, Mohanty B. Formulation and evaluation of buccal patches for delivery of atenolol. AAPS PharmSciTech.
2010;11(3): 1038–1044.
24 Rana P, Murthy RS. Formulation and evaluation of mucoadhesive buccal films impregnated with carvedilol nanosuspension: a potential approach for delivery of drugs having high first-pass metabolism. Drug Delivery. 2013;20(5):224-235.
Published
22/06/2017
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[1]
S. Alagarsamy, M. Vasam, and S. Ravindran, “Phytocompounds used as excipients in mucoadhesive systems an outline on buccal tablets and films”, Int J Indig Herb Drug, pp. 44-48, Jun. 2017.
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Review Articles
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