A Review on neuroprotective potency of crocus sativum L for Alzheimer’s disease

Harikrishna Potu

doi:10.46795/ijhcbs.v5i2.612

Potu Harikrishna Priyadarshini Institute of Pharmaceutical Education and Research, 5th Mile, Pulladigunta, Guntur-522017.Andhra Pradesh, India.

DOI https://doi.org/10.46795/ijhcbs.v5i2.612

Abstract

Regarding cognitive impairment in people suffering from Alzheimer's disease (AD), crocus sativus L., or saffron, appears to have neuroprotective properties. Reviewing the data and mechanisms underlying saffron-induced therapeutic advantages and quantifiable cognitive gains in AD is the aim of this investigation. Preclinical and clinical trials were found after a review of the literature. The following criteria were used to choose preclinical in vitro and in vivo studies: 1) establishing a pharmacological profile for saffron based on biological or biophysical endpoints; 2) assessing the effectiveness of saffron using animal screens as an AD model; and 3) keeping the trials open for a minimum of three months. The patient's age was one of the selection criteria for the clinical research.3) suitable methods to evaluate cognitive, functional, and clinical state; and 4) a diagnosis of AD based on the National Institute on Aging-Alzheimer's Association (NIAAA) criteria. During an initial phase, a total of 1477 studies published up until November 2020 were discovered, 24 of which satisfied the inclusion criteria and were chosen for this review.

Keywords: Saffron, airway inflammation, smooth muscle relaxant effect

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