A literature review on misoprostol versus dinoprostone for induction of labor
Abstract
In recent decades, the proportion of women undergoing induction of labor has increased accordingly within countries, industrialized areas, and various hospitals. The main aim of the article is to review most of the literature in order to provide safety and efficacy to obstetrical care providers on induction of labor. Systematic reviews/meta-analyses, cohort studies, and case-controlled studies that compared safety and efficacy during labor induction. Searches were updated on a regular basis using modified bishop scores. Some of the literature was retrieved from the websites of health technology-related agencies clinical trial agencies and clinical practice guidelines. This review mainly summarizes the controversies concerning the indications, methods for induction of labor, medical uses, contra-indications. This emphasizes the evidence of the safety and effectiveness of misoprostol when compared to dinoprostone during induction of labor.
Keywords:
Induction of Labor, misoprostol, dinoprostone, normal vaginal delivery
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References
1. Dean Leduc, Anne Biringer, Lily Lee, Jessica Dy, Thomas Corbett, Dean Leduc, Anne Biringer, Louise Duperron, Jessica Dy, Ian Lange, Lily Lee, Suzanne Muise, Barbara Parish, Lexy Regush, Kathi Wilson, Grace Yeung, Joan Crane, Robert Gagnon, Diane Sawchuck, Vyta Senikas. Induction of Labour. Journal of Obstetrics and Gynaecology Canada. Volume 35, Issue 9, Sep 2013. Pages 840-857, ISSN 1701-2163.
2. Gibbs RS, Karlan BY, Haney AF, Nygaard I. Danforth’s obstetrics and Gynecology.10th Ed. Lippincott Williams & wilkins; 2008.
3. Osterman MJK, Martin JA. Recent declines in induction of labor by gestational age. NCHS Data Brief. 2014(155): 1–8, indexed in Pubmed: 24941926).
4. Kehl, S., Weiss, C., Dammer, U., Raabe, E., Burghaus, S., Heimrich, J., Hackl, J., Winkler, M., Beckmann, M. W., & Faschingbauer, F. (2015). Induction of Labour: Change of Method and its Effects. Geburtshilfe und Frauenheilkunde, 75(3), 238–243.
5. Calder, AA & Loughney, AD & Weir, C & Barber, J. (2008). Induction of labour in nulliparous and multiparous women: A UK, multicentre, open-label study of intravaginal misoprostol in comparison with dinoprostone. BJOG: an international journal of obstetrics and gynaecology. 115. 1279-88.
6. Grobman WA, Rice MM, Reddy UM, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. N Engl J Med. 2018; 379(6): 513–523, doi: 10.1056/NEJMoa1800566, indexed in Pubmed: 30089070.
7. D’souza AS, Samuel CJ, Katumalla FS, Garg G, Goyal S. A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavorable cervices. Int J Reprod Contracept Obstet Gynecol 2015; 4:1522-8.
8. David Buser, Gerardo Mora, Fernando Arias,A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavorable cervices,Obstetrics & Gynecology,Volume 89, Issue 4,1997,Pages 581-585,ISSN 0029-7844.
9. Thomas J, Fairclough A, Kavanagh J, Kelly AJ. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. Cochrane Database Syst Rev 2014 ;( 6):CD003101.)
10. I.F. Urunsak, U.K. Gulec, E. Eser, M. Sucu, C. Akcabay, S. Buyukkurt,The role of dinoprostone for labor induction in postterm and high-risk term pregnancies,Clinical and Experimental Obstetrics & Gynecology,2020,Clinical and Experimental Obstetrics & Gynecology,47(5), (664).
11. Jakub Mlodawski and Marta Mlodawska and Justyna Plusajska and Jagoda Galuszewska and Kamila Glijer and Stanislaw Gluszek,Misoprostol vaginal insert and Foley catheter in labour induction — single center retrospective observational study of obstetrical outcome,Ginekologia Polska,2020 , vol. 91, no. 11 "issn = 2543-6767.
12. Faucett, A., Daniels, K., Lee, H. et al. Oral misoprostol versus vaginal dinoprostone for labor induction in nulliparous women at term. J Perinatol 34, 95–99 (2014).
13. Mozurkewich, Ellen & Chilimigras, Julie & Berman, Deborah & Perni, Uma & Romero, Vivian & King, Valerie & Keeton, Kristie. (2011). Methods of induction of labour: A systematic review. BMC pregnancy and childbirth. 11. 84.
14. Wannmacher L. Expert Committee Member. MISOPROSTOL (Low dose for labour induction at term).
15. Chodankar, Rohan and Sood, Akanksha and Gupta, Janesh .An overview of the past, current and future trends for cervical ripening in induction of labour. The Obstetrician \& Gynaecologist ,19(3), 219-226.
16. Bishop EH. Pelvic scoring for elective induction. Obstet Gynecol 1964; 24;266–8).
17. Laughon SK, Zhang J, Troendle J, Sun L, Reddy UM. Using a simplified Bishop score to predict vaginal delivery. Obstet Gynecol. 2011; 117(4):805-811.
18. BatinelliL.,SerafiniA.,NanteN.,PetragliaF.,SeveriF.M.,Messina “Inductionoflabour,clinicalpredictivefactorsforsuccessand failure”.J.Obstet.Gynaecol.,2018,38(3),(352-358).
19. CalderAA,Embrey MP,HillierK.Extra-amnioticprostaglandinE2for the induction of labour at term.J Obstet Gynaecol Br Commonw1974;81:39–46.)
20. Lin CJ, Chien SC, Chen CP. The use of misoprostol in termination of second-trimester pregnancy. Taiwan J Obstet Gynecol. 2011 Sep;50(3):275-82. doi: 10.1016/j.tjog.2011.07.003. PMID: 22030039.
21. Goldberg, Alisa B. and Greenberg, Mara B. and Darney, Philip D,Misoprostol and Pregnancy,New England Journal of Medicine, (344)(38-47) (2001).
22. Wikipedia contributors. (2020, November 6). Prostaglandin E2. In Wikipedia, the Free Encyclopedia. Retrieved 10:04, November 10, 2020.
23. Gulshan A. Saeed, Shazia Fakhar, Nadia Nisar, Ali Yawar Alam, Misoprostol for term labor induction: A randomized controlled trial, Taiwanese Journal of Obstetrics and Gynecology,Volume 50, Issue 1,2011, Pages 15-19, ISSN 1028-4559.
24. Bilgin, Zümrüt & Kömürcü, Nuran. (2019). Comparison of the effects and side effects of misoprostol and oxytocin in the postpartum period: A systematic review. Taiwanese Journal of Obstetrics and Gynecology. 58. 748-756.
25. Özkan S, Calişkan E, Doğer E, Yücesoy I, Ozeren S, Vural B. Comparative efficacy and safety on vaginal misoprostol versus dinoprostone vaginal insert in labor induction at term: a randomized trial. Arch Gynecol Obstet. 2009; 280:19–24.
26. Aqueela Ayaz, Saima Shaukat, Mian Usman Farooq, Khalid Mehmood, Iftikhar Ahmad, Muhammad Luqman Ali Bahoo, Induction of Labor: A Comparative Study of Intravaginal Misoprostol and Dinoprostone, Taiwanese Journal of Obstetrics and Gynecology, Volume 49, Issue 2, 2010 Pages 151-155, ISSN 1028-4559.
27. Sawai SK, O'Brien WF. Outpatient cervical ripening. Clinical Obstetrics and Gynecology. 1995 Jun; 38(2):301-309.
28. Wing DA, Paul RH. A comparison of differing dosing regimens of vaginally administered misoprostol for preinduction cervical rip- ening and labor induction. Am J Obstet Gynecol 1996; 175:158-64).
29. Joint Formulary Committee. British National Formulary, 54th edn. London: British Medical Association and Royal Pharmaceutical Society of Great Britain, 2007).
30. National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 5280360, Dinoprostone. Retrieved November 10, 2020.
31. Rezaie M, Farhadifar F, Sadegh SM, Nayebi M. Comparison of Vaginal and Oral Doses of Misoprostol for Labour Induction in Post-Term Pregnancies. J Clin Diagn Res. 2016; 10(3):QC08-QC11.
32. Towers CV, Briggs GG, Rojas JA. The use of prostaglandin E2 in pregnant patients with asthma. Am J Obstet Gynecol 2004; 190:1777.
33. Neiger R, Greaves PC. Comparison between vaginal misoprostol and cervical dinoprostone for cervical ripening and labour induction. Tenn Med 2001; 94:2527.
34. Agarwal N, Gupta A, Kriplani A, Bhatla N, Parul. Six hourly vaginal misoprostol versus intracervical dinoprostone for cervical ripening and labor induction. J Obstet Gynaecol Res 2003; 29(3):147-151.
35. Buser D, Mora G, Arias F. A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavourable cervices. Obstet Gynecol. 1997; 89:581-5.
36. D’souza AS, Samuel CJ, Katumalla FS, Garg G, Goyal S. A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavorable cervices. Int J Reprod Contracept Obstet Gynecol 2015; 4:1522-8.
37. Kolderup L, McLean L, Grullon K, Safford K, Kilpatrick SJ. Misoprostol is more efficacious for labor induction than prostaglandin E2, but is it associated with more risk? Am J Obstet Gynecol. 1999; 180:1543-50.9.
38. Wing DA, Jones MM, Rahall A, Goodwin TM, Paul RH. Misoprostol an effective agent for cervical ripening and labor induction. Am J Obstet Gynecol. 1995; 172:1811-6.
39. Silfeler DB, Tandogan B, Ayvaci H, Silfeler I, Yenidede I, Dayicioglu V. A comparison of misoprostol, controlled-release dinoprostone vaginal insert and oxytocin for cervical ripening. Arch Gynecol Obstet. 2011; 284:1331–7.
40. Abraham C, Meirowitz N, Kohn N. Labor induction for premature rupture of membranes using vaginal misoprostol versus Dinoprostone vaginal insert. Am J Perinatol. 2014; 31:181–6.
2. Gibbs RS, Karlan BY, Haney AF, Nygaard I. Danforth’s obstetrics and Gynecology.10th Ed. Lippincott Williams & wilkins; 2008.
3. Osterman MJK, Martin JA. Recent declines in induction of labor by gestational age. NCHS Data Brief. 2014(155): 1–8, indexed in Pubmed: 24941926).
4. Kehl, S., Weiss, C., Dammer, U., Raabe, E., Burghaus, S., Heimrich, J., Hackl, J., Winkler, M., Beckmann, M. W., & Faschingbauer, F. (2015). Induction of Labour: Change of Method and its Effects. Geburtshilfe und Frauenheilkunde, 75(3), 238–243.
5. Calder, AA & Loughney, AD & Weir, C & Barber, J. (2008). Induction of labour in nulliparous and multiparous women: A UK, multicentre, open-label study of intravaginal misoprostol in comparison with dinoprostone. BJOG: an international journal of obstetrics and gynaecology. 115. 1279-88.
6. Grobman WA, Rice MM, Reddy UM, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. N Engl J Med. 2018; 379(6): 513–523, doi: 10.1056/NEJMoa1800566, indexed in Pubmed: 30089070.
7. D’souza AS, Samuel CJ, Katumalla FS, Garg G, Goyal S. A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavorable cervices. Int J Reprod Contracept Obstet Gynecol 2015; 4:1522-8.
8. David Buser, Gerardo Mora, Fernando Arias,A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavorable cervices,Obstetrics & Gynecology,Volume 89, Issue 4,1997,Pages 581-585,ISSN 0029-7844.
9. Thomas J, Fairclough A, Kavanagh J, Kelly AJ. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. Cochrane Database Syst Rev 2014 ;( 6):CD003101.)
10. I.F. Urunsak, U.K. Gulec, E. Eser, M. Sucu, C. Akcabay, S. Buyukkurt,The role of dinoprostone for labor induction in postterm and high-risk term pregnancies,Clinical and Experimental Obstetrics & Gynecology,2020,Clinical and Experimental Obstetrics & Gynecology,47(5), (664).
11. Jakub Mlodawski and Marta Mlodawska and Justyna Plusajska and Jagoda Galuszewska and Kamila Glijer and Stanislaw Gluszek,Misoprostol vaginal insert and Foley catheter in labour induction — single center retrospective observational study of obstetrical outcome,Ginekologia Polska,2020 , vol. 91, no. 11 "issn = 2543-6767.
12. Faucett, A., Daniels, K., Lee, H. et al. Oral misoprostol versus vaginal dinoprostone for labor induction in nulliparous women at term. J Perinatol 34, 95–99 (2014).
13. Mozurkewich, Ellen & Chilimigras, Julie & Berman, Deborah & Perni, Uma & Romero, Vivian & King, Valerie & Keeton, Kristie. (2011). Methods of induction of labour: A systematic review. BMC pregnancy and childbirth. 11. 84.
14. Wannmacher L. Expert Committee Member. MISOPROSTOL (Low dose for labour induction at term).
15. Chodankar, Rohan and Sood, Akanksha and Gupta, Janesh .An overview of the past, current and future trends for cervical ripening in induction of labour. The Obstetrician \& Gynaecologist ,19(3), 219-226.
16. Bishop EH. Pelvic scoring for elective induction. Obstet Gynecol 1964; 24;266–8).
17. Laughon SK, Zhang J, Troendle J, Sun L, Reddy UM. Using a simplified Bishop score to predict vaginal delivery. Obstet Gynecol. 2011; 117(4):805-811.
18. BatinelliL.,SerafiniA.,NanteN.,PetragliaF.,SeveriF.M.,Messina “Inductionoflabour,clinicalpredictivefactorsforsuccessand failure”.J.Obstet.Gynaecol.,2018,38(3),(352-358).
19. CalderAA,Embrey MP,HillierK.Extra-amnioticprostaglandinE2for the induction of labour at term.J Obstet Gynaecol Br Commonw1974;81:39–46.)
20. Lin CJ, Chien SC, Chen CP. The use of misoprostol in termination of second-trimester pregnancy. Taiwan J Obstet Gynecol. 2011 Sep;50(3):275-82. doi: 10.1016/j.tjog.2011.07.003. PMID: 22030039.
21. Goldberg, Alisa B. and Greenberg, Mara B. and Darney, Philip D,Misoprostol and Pregnancy,New England Journal of Medicine, (344)(38-47) (2001).
22. Wikipedia contributors. (2020, November 6). Prostaglandin E2. In Wikipedia, the Free Encyclopedia. Retrieved 10:04, November 10, 2020.
23. Gulshan A. Saeed, Shazia Fakhar, Nadia Nisar, Ali Yawar Alam, Misoprostol for term labor induction: A randomized controlled trial, Taiwanese Journal of Obstetrics and Gynecology,Volume 50, Issue 1,2011, Pages 15-19, ISSN 1028-4559.
24. Bilgin, Zümrüt & Kömürcü, Nuran. (2019). Comparison of the effects and side effects of misoprostol and oxytocin in the postpartum period: A systematic review. Taiwanese Journal of Obstetrics and Gynecology. 58. 748-756.
25. Özkan S, Calişkan E, Doğer E, Yücesoy I, Ozeren S, Vural B. Comparative efficacy and safety on vaginal misoprostol versus dinoprostone vaginal insert in labor induction at term: a randomized trial. Arch Gynecol Obstet. 2009; 280:19–24.
26. Aqueela Ayaz, Saima Shaukat, Mian Usman Farooq, Khalid Mehmood, Iftikhar Ahmad, Muhammad Luqman Ali Bahoo, Induction of Labor: A Comparative Study of Intravaginal Misoprostol and Dinoprostone, Taiwanese Journal of Obstetrics and Gynecology, Volume 49, Issue 2, 2010 Pages 151-155, ISSN 1028-4559.
27. Sawai SK, O'Brien WF. Outpatient cervical ripening. Clinical Obstetrics and Gynecology. 1995 Jun; 38(2):301-309.
28. Wing DA, Paul RH. A comparison of differing dosing regimens of vaginally administered misoprostol for preinduction cervical rip- ening and labor induction. Am J Obstet Gynecol 1996; 175:158-64).
29. Joint Formulary Committee. British National Formulary, 54th edn. London: British Medical Association and Royal Pharmaceutical Society of Great Britain, 2007).
30. National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 5280360, Dinoprostone. Retrieved November 10, 2020.
31. Rezaie M, Farhadifar F, Sadegh SM, Nayebi M. Comparison of Vaginal and Oral Doses of Misoprostol for Labour Induction in Post-Term Pregnancies. J Clin Diagn Res. 2016; 10(3):QC08-QC11.
32. Towers CV, Briggs GG, Rojas JA. The use of prostaglandin E2 in pregnant patients with asthma. Am J Obstet Gynecol 2004; 190:1777.
33. Neiger R, Greaves PC. Comparison between vaginal misoprostol and cervical dinoprostone for cervical ripening and labour induction. Tenn Med 2001; 94:2527.
34. Agarwal N, Gupta A, Kriplani A, Bhatla N, Parul. Six hourly vaginal misoprostol versus intracervical dinoprostone for cervical ripening and labor induction. J Obstet Gynaecol Res 2003; 29(3):147-151.
35. Buser D, Mora G, Arias F. A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavourable cervices. Obstet Gynecol. 1997; 89:581-5.
36. D’souza AS, Samuel CJ, Katumalla FS, Garg G, Goyal S. A randomized comparison between misoprostol and dinoprostone for cervical ripening and labor induction in patients with unfavorable cervices. Int J Reprod Contracept Obstet Gynecol 2015; 4:1522-8.
37. Kolderup L, McLean L, Grullon K, Safford K, Kilpatrick SJ. Misoprostol is more efficacious for labor induction than prostaglandin E2, but is it associated with more risk? Am J Obstet Gynecol. 1999; 180:1543-50.9.
38. Wing DA, Jones MM, Rahall A, Goodwin TM, Paul RH. Misoprostol an effective agent for cervical ripening and labor induction. Am J Obstet Gynecol. 1995; 172:1811-6.
39. Silfeler DB, Tandogan B, Ayvaci H, Silfeler I, Yenidede I, Dayicioglu V. A comparison of misoprostol, controlled-release dinoprostone vaginal insert and oxytocin for cervical ripening. Arch Gynecol Obstet. 2011; 284:1331–7.
40. Abraham C, Meirowitz N, Kohn N. Labor induction for premature rupture of membranes using vaginal misoprostol versus Dinoprostone vaginal insert. Am J Perinatol. 2014; 31:181–6.
Published
30/01/2022
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How to Cite
M, N., S. K. K, H. P, S. B, R. D, and R. R. V. “A Literature Review on Misoprostol Versus Dinoprostone for Induction of Labor”. International Journal of Health Care and Biological Sciences, Vol. 3, no. 1, Jan. 2022, pp. 15-21, doi:10.46795/ijhcbs.v3i1.279.
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