Formulation development and invitro evaluation of captopril fast dissolving oral thin films by solvent casting method
Abstract
The present study formulation development of captopril oral thin films by using solvent casting method .the formulation contain the Crospovidone was found At 4% w/w of crospovidone with 3% PVA concentration level dispersion time of 7.23±0.151 sec highest release of more than 99.27% drug in 30 min. therefore the formulation contain shows the better formulation.
Keywords:
captopril, crospovidine, super disintegrants, solvent casting method
Downloads
Download data is not yet available.
References
1. Dixit R, Puthli S. Oral strip technology: Overview and future potential. J. Control Release 2009; 139: 94-107.
2. Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: An Innovative Drug Delivery system and Dosage form. Int. J. Chem. Tech. Res. 2010:2: 576-83.
3. Mashru C, Sutariya V, Sankali M, Parikh P. Development and evaluation of fast-dissolving film of salbutamol sulphate. Drug Dev. Ind. Pharm. 2005; 31: 25-34.
4. Nishimura M, Matsuurab K, Tsukioka T, Yamashita H, Inagaki N, Sugiyama T, Itoh Y. In vitro and in vivo characteristics of prochlorperazine oral disintegrating film. International Journal of Pharmaceutics 2009 Oct 15; 398: 98–102.
5. Shimoda H, Taniguchi K, Nishimura M, Matsuura K, Tsukikoka T, Yamashita H, Hirano K, Yamamoto M, Kinosada Y, Itoh Y. Preparation of a fast dissolving oral thin film containing dexamethasone: A possible application to antiemesis during cancer chemotherapy. European Journal of Pharmaceutics and Biopharmaceutics. 2009 Aug 31.
6. Slowson M, Slowson, S. What to do when patients cannot swallow their medications. Pharm Times. 1985;51: 90-96.
7. Doheny K. You really expect me to swallow those horse pills? Am Druggist. 1993; 208: 34-35.
8. Tora-Tora Gorahowski. Principles of Anatomy and Physiology, 7th Edition edited by Gerad J. Tora-Tora and Sandro Reynolds Gorahowski, published Harpet Collins College Publishers; 1992: 770-4.
9. Ross and Wilson. Anatomy and Physiology in Health and Illness, 9th Edition edited by Anne Waugh and Allison Goraw published by Churchill Livingstone Edinburgh; 2001: 289
10. www.ondrugdelivery.com
11. Vondrak B, Barnhart S. Dissolvable Films for Flexible Product Format in Drug Delivery, Pharmaceutical Technology Supplement. April 2008.
12. Frey P. .Film Strips and Pharmaceuticals,. Pharma. Mfg. & Packag. Sourcer, winter, 2006: 92.93.
13. Zhang H, Zhang J, Streisand J.B. Oral mucosal drug delivery: clinical pharmaco- kinetics and therapeutic applications, Clin. Pharmacokinet.2002; 41 (9): 661-680.
14. Barnhart SD, Sloboda MS. The Future of Dissolvable Films. Drug Delivery Technol. 2007;7 (8): 34-37.
15. Meathrel B, Moritz C. Dissolvable Films and Their Potential in IVDs. IVD Technol. 2007; 13 (9): 53-58.
16. Mishra R, Amin A. Quick API Delivery. Pharmaceutical Technology Europe : 1-5.
17. Marabathuni VJ, Dinesh P, Ravikumar R, Yamini P, Kiran PS, Hussain SP, Rao CM. Chitosan based sustained release mucoadhesive buccal patches containing amlodipine besylate (AMB). Asian Journal of Research in Pharmaceutical Science. 2017;7(2):97-104.
18. Marabathuni VJ, Bhavani M, Lavanya M, Padmaja K, Madhavi N, Babu P, Rao CM. Formulation and evaluation of mouth dissolving Tablets of carbamazepine. Asian Journal of Pharmacy and Technology. 2017;7(3):137-43.
19. Babu AK, Teja NB, Ramakrishna B, Kumar BB, Reddy GV. Formulation and evaluation of double walled microspheres loaded with pantoprazole. METHODS. 2011;15:28.
20. Babu AK, Reddy VR, Reddy N, Vidyasagar J. Evaluating the post compression parameter of ibuprofen by using super disintegrants. An Int J Adv Pharm Sci. 2010;1(2):247-53.
21. Aruna MS, Babu AK, Thadanki M, Gupta ME. Solid dispersions–an approach to enhance the dissolution rate of Irbesartan. IJRPC. 2011;1(4):780-7.
22. Babu K, Ramana MV. Development and in vivo evaluation of gastro retentive floating tablets of antipsychotic drug risperidone. Int J Pharm Pharm Sci. 2016; 11:43-52.
23. Babu AK, Ramana MV. In Vitro and In Vivo Evaluation of Quetiapine Fumarate controlled gastroretentive floating drug delivery system
2. Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: An Innovative Drug Delivery system and Dosage form. Int. J. Chem. Tech. Res. 2010:2: 576-83.
3. Mashru C, Sutariya V, Sankali M, Parikh P. Development and evaluation of fast-dissolving film of salbutamol sulphate. Drug Dev. Ind. Pharm. 2005; 31: 25-34.
4. Nishimura M, Matsuurab K, Tsukioka T, Yamashita H, Inagaki N, Sugiyama T, Itoh Y. In vitro and in vivo characteristics of prochlorperazine oral disintegrating film. International Journal of Pharmaceutics 2009 Oct 15; 398: 98–102.
5. Shimoda H, Taniguchi K, Nishimura M, Matsuura K, Tsukikoka T, Yamashita H, Hirano K, Yamamoto M, Kinosada Y, Itoh Y. Preparation of a fast dissolving oral thin film containing dexamethasone: A possible application to antiemesis during cancer chemotherapy. European Journal of Pharmaceutics and Biopharmaceutics. 2009 Aug 31.
6. Slowson M, Slowson, S. What to do when patients cannot swallow their medications. Pharm Times. 1985;51: 90-96.
7. Doheny K. You really expect me to swallow those horse pills? Am Druggist. 1993; 208: 34-35.
8. Tora-Tora Gorahowski. Principles of Anatomy and Physiology, 7th Edition edited by Gerad J. Tora-Tora and Sandro Reynolds Gorahowski, published Harpet Collins College Publishers; 1992: 770-4.
9. Ross and Wilson. Anatomy and Physiology in Health and Illness, 9th Edition edited by Anne Waugh and Allison Goraw published by Churchill Livingstone Edinburgh; 2001: 289
10. www.ondrugdelivery.com
11. Vondrak B, Barnhart S. Dissolvable Films for Flexible Product Format in Drug Delivery, Pharmaceutical Technology Supplement. April 2008.
12. Frey P. .Film Strips and Pharmaceuticals,. Pharma. Mfg. & Packag. Sourcer, winter, 2006: 92.93.
13. Zhang H, Zhang J, Streisand J.B. Oral mucosal drug delivery: clinical pharmaco- kinetics and therapeutic applications, Clin. Pharmacokinet.2002; 41 (9): 661-680.
14. Barnhart SD, Sloboda MS. The Future of Dissolvable Films. Drug Delivery Technol. 2007;7 (8): 34-37.
15. Meathrel B, Moritz C. Dissolvable Films and Their Potential in IVDs. IVD Technol. 2007; 13 (9): 53-58.
16. Mishra R, Amin A. Quick API Delivery. Pharmaceutical Technology Europe : 1-5.
17. Marabathuni VJ, Dinesh P, Ravikumar R, Yamini P, Kiran PS, Hussain SP, Rao CM. Chitosan based sustained release mucoadhesive buccal patches containing amlodipine besylate (AMB). Asian Journal of Research in Pharmaceutical Science. 2017;7(2):97-104.
18. Marabathuni VJ, Bhavani M, Lavanya M, Padmaja K, Madhavi N, Babu P, Rao CM. Formulation and evaluation of mouth dissolving Tablets of carbamazepine. Asian Journal of Pharmacy and Technology. 2017;7(3):137-43.
19. Babu AK, Teja NB, Ramakrishna B, Kumar BB, Reddy GV. Formulation and evaluation of double walled microspheres loaded with pantoprazole. METHODS. 2011;15:28.
20. Babu AK, Reddy VR, Reddy N, Vidyasagar J. Evaluating the post compression parameter of ibuprofen by using super disintegrants. An Int J Adv Pharm Sci. 2010;1(2):247-53.
21. Aruna MS, Babu AK, Thadanki M, Gupta ME. Solid dispersions–an approach to enhance the dissolution rate of Irbesartan. IJRPC. 2011;1(4):780-7.
22. Babu K, Ramana MV. Development and in vivo evaluation of gastro retentive floating tablets of antipsychotic drug risperidone. Int J Pharm Pharm Sci. 2016; 11:43-52.
23. Babu AK, Ramana MV. In Vitro and In Vivo Evaluation of Quetiapine Fumarate controlled gastroretentive floating drug delivery system
Published
17/01/2022
Statistics
300 Views | 233 Downloads
Citatons
How to Cite
Naik, N. G., V. J. P. Marabathuni, and N. Narapusetty. “Formulation Development and Invitro Evaluation of Captopril Fast Dissolving Oral Thin Films by Solvent Casting Method”. International Journal of Health Care and Biological Sciences, Vol. 3, no. 1, Jan. 2022, pp. 01-07, doi:10.46795/ijhcbs.v3i1.261.
Issue
Section
Research Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
.